Plscr1 (phospholipid scramblase 1) - Rat Genome Database

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Gene: Plscr1 (phospholipid scramblase 1) Rattus norvegicus
Analyze
Symbol: Plscr1
Name: phospholipid scramblase 1
RGD ID: 620521
Description: Enables enzyme binding activity. Involved in several processes, including plasma membrane phospholipid scrambling; regulation of Fc receptor mediated stimulatory signaling pathway; and regulation of mast cell activation. Located in membrane raft and plasma membrane. Orthologous to human PLSCR1 (phospholipid scramblase 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ca(2+)-dependent phospholipid scramblase 1; mg(2+)-dependent nuclease; MGC93252; phospholipid scramblase 2; PL scramblase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88101,662,512 - 101,684,474 (+)NCBIGRCr8
mRatBN7.2892,784,279 - 92,804,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl892,784,356 - 92,804,692 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx898,462,546 - 98,482,894 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0896,661,795 - 96,682,143 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0894,494,749 - 94,515,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0899,625,523 - 99,645,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl899,625,545 - 99,725,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0899,108,895 - 99,129,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4897,206,388 - 97,226,725 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1897,225,842 - 97,246,179 (+)NCBI
Celera892,307,776 - 92,328,258 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
indole-3-methanol  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxycodone  (EXP)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
collagen-containing extracellular matrix  (ISO,ISS)
cytoplasm  (ISO)
cytosol  (ISO,ISS)
Golgi apparatus  (ISO,ISS)
membrane raft  (IDA,ISO)
nucleolus  (ISO,ISS)
nucleoplasm  (ISO)
nucleus  (ISO,ISS)
perinuclear region of cytoplasm  (ISO,ISS)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. Amir-Moazami O, etal., J Biol Chem. 2008 Sep 12;283(37):25514-23. Epub 2008 Jun 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. Kantari C, etal., Blood. 2007 Dec 1;110(12):4086-95. Epub 2007 Aug 21.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase. Pastorelli C, etal., J Biol Chem 2001 Jun 8;276(23):20407-12.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9218461   PMID:10770950   PMID:11390389   PMID:12009895   PMID:12477932   PMID:12509439   PMID:12586838   PMID:15308695   PMID:15328404   PMID:15863367   PMID:16091359   PMID:16611984  
PMID:17567603   PMID:17590392   PMID:18281686   PMID:18629440   PMID:19056867   PMID:19333378   PMID:19946888   PMID:20870722   PMID:22052202   PMID:23376485   PMID:23533145   PMID:24356419  
PMID:25289695  


Genomics

Comparative Map Data
Plscr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88101,662,512 - 101,684,474 (+)NCBIGRCr8
mRatBN7.2892,784,279 - 92,804,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl892,784,356 - 92,804,692 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx898,462,546 - 98,482,894 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0896,661,795 - 96,682,143 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0894,494,749 - 94,515,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0899,625,523 - 99,645,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl899,625,545 - 99,725,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0899,108,895 - 99,129,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4897,206,388 - 97,226,725 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1897,225,842 - 97,246,179 (+)NCBI
Celera892,307,776 - 92,328,258 (+)NCBICelera
Cytogenetic Map8q31NCBI
PLSCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383146,515,180 - 146,544,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3146,515,180 - 146,544,856 (-)EnsemblGRCh38hg38GRCh38
GRCh373146,232,967 - 146,262,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363147,715,658 - 147,745,186 (-)NCBINCBI36Build 36hg18NCBI36
Build 343147,715,665 - 147,745,194NCBI
Celera3144,649,990 - 144,679,651 (-)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3143,609,792 - 143,639,453 (-)NCBIHuRef
CHM1_13146,196,031 - 146,225,691 (-)NCBICHM1_1
T2T-CHM13v2.03149,270,345 - 149,299,772 (-)NCBIT2T-CHM13v2.0
Plscr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39992,132,265 - 92,154,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl992,131,803 - 92,154,331 (+)EnsemblGRCm39 Ensembl
GRCm38992,250,194 - 92,272,561 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl992,249,750 - 92,272,278 (+)EnsemblGRCm38mm10GRCm38
MGSCv37992,145,032 - 92,167,399 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36992,063,114 - 92,075,746 (+)NCBIMGSCv36mm8
Celera991,837,716 - 91,860,050 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map948.35NCBI
Plscr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547410,953,381 - 10,989,100 (+)NCBIChiLan1.0ChiLan1.0
PLSCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22144,397,437 - 144,426,848 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13144,402,168 - 144,431,880 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03143,528,967 - 143,558,468 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13151,111,622 - 151,141,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3151,112,483 - 151,132,964 (-)Ensemblpanpan1.1panPan2
PLSCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12341,639,938 - 41,668,972 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2341,599,843 - 41,669,112 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2341,505,247 - 41,534,148 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02342,258,129 - 42,287,174 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2342,258,522 - 42,287,370 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12341,846,168 - 41,875,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02341,921,170 - 41,950,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02342,164,670 - 42,193,494 (-)NCBIUU_Cfam_GSD_1.0
Plscr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560280,943,177 - 80,974,329 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365198,759,702 - 8,790,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLSCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1386,834,587 - 86,869,297 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11386,836,288 - 86,869,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLSCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11544,160,017 - 44,189,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1544,160,200 - 44,188,195 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604117,044,147 - 17,072,858 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Plscr1
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:178
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000010689, ENSRNOT00000056727
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat

Markers in Region
AI237617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2892,802,573 - 92,802,762 (+)MAPPERmRatBN7.2
Rnor_6.0899,643,763 - 99,643,951NCBIRnor6.0
Rnor_5.0899,127,132 - 99,127,320UniSTSRnor5.0
RGSC_v3.4897,224,606 - 97,224,794UniSTSRGSC3.4
Celera892,326,139 - 92,326,327UniSTS
RH 3.4 Map81041.0UniSTS
Cytogenetic Map8q31UniSTS
RH143342  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2892,794,298 - 92,794,423 (+)MAPPERmRatBN7.2
Rnor_6.0899,635,488 - 99,635,612NCBIRnor6.0
Rnor_5.0899,118,857 - 99,118,981UniSTSRnor5.0
RGSC_v3.4897,216,331 - 97,216,455UniSTSRGSC3.4
Celera892,317,747 - 92,317,871UniSTS
RH 3.4 Map81041.2UniSTS
Cytogenetic Map8q31UniSTS
RH141661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2892,800,832 - 92,801,041 (+)MAPPERmRatBN7.2
Rnor_6.0899,642,022 - 99,642,230NCBIRnor6.0
Rnor_5.0899,125,391 - 99,125,599UniSTSRnor5.0
RGSC_v3.4897,222,865 - 97,223,073UniSTSRGSC3.4
Celera892,324,398 - 92,324,606UniSTS
RH 3.4 Map81040.9UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 14 19 14 31 12 11
Low 43 33 27 27 8 11 74 4 28 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010689   ⟹   ENSRNOP00000010689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl892,784,356 - 92,804,692 (+)Ensembl
Rnor_6.0 Ensembl899,625,545 - 99,645,881 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000056727   ⟹   ENSRNOP00000053569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl892,784,413 - 92,804,692 (+)Ensembl
Rnor_6.0 Ensembl899,625,602 - 99,645,881 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086524   ⟹   ENSRNOP00000074296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl892,796,430 - 92,804,692 (+)Ensembl
Rnor_6.0 Ensembl899,636,749 - 99,645,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087190   ⟹   ENSRNOP00000071411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl892,796,173 - 92,804,692 (+)Ensembl
Rnor_6.0 Ensembl899,632,803 - 99,725,217 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089624   ⟹   ENSRNOP00000070590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl899,713,783 - 99,725,021 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100353   ⟹   ENSRNOP00000088746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl892,784,356 - 92,804,692 (+)Ensembl
RefSeq Acc Id: NM_001423659   ⟹   NP_001410588
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88101,664,121 - 101,684,474 (+)NCBI
RefSeq Acc Id: NM_057194   ⟹   NP_476542
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88101,664,121 - 101,684,474 (+)NCBI
mRatBN7.2892,784,356 - 92,804,693 (+)NCBI
Rnor_6.0899,625,545 - 99,645,882 (+)NCBI
Rnor_5.0899,108,895 - 99,129,251 (+)NCBI
RGSC_v3.4897,206,388 - 97,226,725 (+)RGD
Celera892,307,776 - 92,328,258 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243537   ⟹   XP_006243599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88101,662,512 - 101,684,474 (+)NCBI
mRatBN7.2892,784,279 - 92,804,698 (+)NCBI
Rnor_6.0899,625,523 - 99,645,882 (+)NCBI
Rnor_5.0899,108,895 - 99,129,251 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243538   ⟹   XP_006243600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88101,664,055 - 101,684,474 (+)NCBI
mRatBN7.2892,784,281 - 92,804,698 (+)NCBI
Rnor_6.0899,625,524 - 99,645,882 (+)NCBI
Rnor_5.0899,108,895 - 99,129,251 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_476542   ⟸   NM_057194
- Peptide Label: isoform 1
- UniProtKB: P58195 (UniProtKB/Swiss-Prot),   A6I238 (UniProtKB/TrEMBL),   A0A8L2Q4J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243599   ⟸   XM_006243537
- Peptide Label: isoform X1
- UniProtKB: Q5U351 (UniProtKB/TrEMBL),   F7F624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243600   ⟸   XM_006243538
- Peptide Label: isoform X2
- UniProtKB: P58195 (UniProtKB/Swiss-Prot),   A6I238 (UniProtKB/TrEMBL),   A0A8L2Q4J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070590   ⟸   ENSRNOT00000089624
RefSeq Acc Id: ENSRNOP00000071411   ⟸   ENSRNOT00000087190
RefSeq Acc Id: ENSRNOP00000053569   ⟸   ENSRNOT00000056727
RefSeq Acc Id: ENSRNOP00000010689   ⟸   ENSRNOT00000010689
RefSeq Acc Id: ENSRNOP00000074296   ⟸   ENSRNOT00000086524
RefSeq Acc Id: ENSRNOP00000088746   ⟸   ENSRNOT00000100353
RefSeq Acc Id: NP_001410588   ⟸   NM_001423659
- Peptide Label: isoform 2
- UniProtKB: Q5U351 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P58195-F1-model_v2 AlphaFold P58195 1-335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696180
Promoter ID:EPDNEW_R6705
Type:initiation region
Name:Plscr1_1
Description:phospholipid scramblase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6706  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0899,625,529 - 99,625,589EPDNEW
RGD ID:13696187
Promoter ID:EPDNEW_R6706
Type:initiation region
Name:Plscr1_2
Description:phospholipid scramblase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6705  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0899,625,666 - 99,625,726EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620521 AgrOrtholog
BioCyc Gene G2FUF-29558 BioCyc
Ensembl Genes ENSRNOG00000008048 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010689 ENTREZGENE
  ENSRNOT00000010689.9 UniProtKB/TrEMBL
  ENSRNOT00000056727.4 UniProtKB/TrEMBL
  ENSRNOT00000086524.2 UniProtKB/TrEMBL
  ENSRNOT00000087190.2 UniProtKB/TrEMBL
  ENSRNOT00000100353.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109899 IMAGE-MGC_LOAD
InterPro Scramblase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93252 IMAGE-MGC_LOAD
NCBI Gene 117540 ENTREZGENE
PANTHER PHOSPHOLIPID SCRAMBLASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23248 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Scramblase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plscr1 PhenoGen
RatGTEx ENSRNOG00000008048 RatGTEx
UniProt A0A0G2K0E4_RAT UniProtKB/TrEMBL
  A0A0G2K7Q1_RAT UniProtKB/TrEMBL
  A0A8I6AJG5_RAT UniProtKB/TrEMBL
  A0A8L2Q4J9 ENTREZGENE, UniProtKB/TrEMBL
  A6I238 ENTREZGENE, UniProtKB/TrEMBL
  F7F624 ENTREZGENE, UniProtKB/TrEMBL
  P58195 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5U351 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Plscr1  phospholipid scramblase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Plscr1  phospholipid scramblase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation target of IgE receptor dependent tyrosine phosphorylation 727313