Ugt2b (UDP glycosyltransferase 2 family, polypeptide B) - Rat Genome Database

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Gene: Ugt2b (UDP glycosyltransferase 2 family, polypeptide B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt2b
Name: UDP glycosyltransferase 2 family, polypeptide B
RGD ID: 3936
Description: Enables glucuronosyltransferase activity. Predicted to be involved in cellular glucuronidation and estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-hydroxyandrogen specific; 3-hydroxyandrogen-specific UDPGT; Androsterone UDP-glucuronosyltransferase; LOC688226; RLUG23; UDP glucuronosyltransferase; UDP-glucuronosyltransferase 2B2; UDPGT 2B2; UDPGTr-4; Ugt2b2
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Ugt2b-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,985,449 - 21,006,267 (+)NCBIGRCr8
mRatBN7.21420,630,572 - 20,665,062 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,630,250 - 20,651,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,820,758 - 20,841,575 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,139,677 - 22,160,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0 Ensembl1422,375,955 - 22,534,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01422,323,542 - 22,344,064 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,154,370 - 22,178,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11422,066,518 - 22,177,852 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The full length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family. Jackson MR and Burchell B, Nucleic Acids Res 1986 Jan 24;14(2):779-95.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens. Mackenzie PI J Biol Chem 1986 Oct 25;261(30):14112-7.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1909872   PMID:7492328   PMID:12477932   PMID:17435758   PMID:23230277  


Genomics

Variants

.
Variants in Ugt2b
448 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000052369
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat

Markers in Region
RH127922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21420,651,730 - 20,651,948 (+)MAPPERmRatBN7.2
Rnor_6.01422,438,390 - 22,438,607NCBIRnor6.0
Rnor_6.01422,157,582 - 22,157,799NCBIRnor6.0
Rnor_5.01422,071,655 - 22,071,872UniSTSRnor5.0
Rnor_5.01422,344,386 - 22,344,603UniSTSRnor5.0
RGSC_v3.41422,179,529 - 22,179,746UniSTSRGSC3.4
RGSC_v3.41422,178,177 - 22,179,746UniSTSRGSC3.4
Cytogenetic Map14p22-p21.2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000052369   ⟹   ENSRNOP00000043239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,630,250 - 20,651,776 (+)Ensembl
RefSeq Acc Id: NM_031533   ⟹   NP_113721
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,985,449 - 21,006,267 (+)NCBI
mRatBN7.21420,630,591 - 20,651,409 (+)NCBI
Rnor_5.01422,323,542 - 22,344,064 (+)NCBI
RGSC_v3.41422,154,370 - 22,178,222 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89792 (Get FASTA)   NCBI Sequence Viewer  
  CAA27198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043239
  ENSRNOP00000043239.5
GenBank Protein P08541 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_113721   ⟸   NM_031533
- Peptide Label: precursor
- UniProtKB: Q5EBC8 (UniProtKB/TrEMBL),   A1XF83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043239   ⟸   ENSRNOT00000052369

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08541-F1-model_v2 AlphaFold P08541 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3936 AgrOrtholog
BioCyc Gene G2FUF-16112 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6398 [melatonin degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
  PWY-6261 BioCyc
  PWY-6313 BioCyc
  PWY-6398 BioCyc
Ensembl Genes ENSRNOG00000046540 Ensembl
  ENSRNOG00000069670 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052369 ENTREZGENE
  ENSRNOT00000052369.6 UniProtKB/TrEMBL
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370057 IMAGE-MGC_LOAD
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24862 UniProtKB/TrEMBL
MGC_CLONE MGC:108656 IMAGE-MGC_LOAD
NCBI Gene 24862 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B38-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ugt2b PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046540 RatGTEx
  ENSRNOG00000069670 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1XF83 ENTREZGENE, UniProtKB/TrEMBL
  F1LM22_RAT UniProtKB/TrEMBL
  P08541 ENTREZGENE
  Q5EBC8 ENTREZGENE, UniProtKB/TrEMBL
  UD2B2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Ugt2b  UDP glycosyltransferase 2 family, polypeptide B  LOC688226  similar to UDP-glucuronosyltransferase 2B2 precursor (UDPGT) (3-hydroxyandrogen specific) (UDPGTr-4) (RLUG23)  Data merged from RGD:1591199 737654 PROVISIONAL
2006-11-20 LOC688226  similar to UDP-glucuronosyltransferase 2B2 precursor (UDPGT) (3-hydroxyandrogen specific) (UDPGTr-4) (RLUG23)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Ugt2b  UDP glycosyltransferase 2 family, polypeptide B  Ugt2b2  Androsterone UDP-glucuronosyltransferase  Symbol and Name updated 629477 APPROVED
2002-06-10 Ugt2b2  Androsterone UDP-glucuronosyltransferase      Symbol and Name status set to approved 70586 APPROVED