Stat3 (signal transducer and activator of transcription 3) - Rat Genome Database

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Gene: Stat3 (signal transducer and activator of transcription 3) Rattus norvegicus
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Symbol: Stat3
Name: signal transducer and activator of transcription 3
RGD ID: 3772
Description: Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of hydrogen peroxide biosynthetic process; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; mitochondrial inner membrane; and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Biomarker of atherosclerosis; colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3); PARTICIPATES IN Interleukin-10 signaling pathway; epidermal growth factor/neuregulin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-taxifolin; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93551; signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,311,528 - 86,363,513 (-)NCBIGRCr8
mRatBN7.21085,811,206 - 85,863,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,847,511 - 90,899,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,326,207 - 90,377,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,719,368 - 85,771,150 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alzheimer's disease  (ISO)
anaplastic large cell lymphoma  (ISO)
angiomyolipoma  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (IEP,ISO)
Atrophy  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IDA,IMP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic lymphocytic leukemia  (ISO)
Churg-Strauss syndrome  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISS)
colorectal carcinoma  (IEP)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
Copper-Overload Cirrhosis  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
Diabetic Nephropathies  (IDA)
diffuse large B-cell lymphoma  (ISO)
duodenal ulcer  (IMP)
Endometrial Neoplasms  (ISO)
Epidermal Hyperplasia  (ISO)
esophageal carcinoma  (ISO)
Experimental Arthritis  (IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Experimental Neoplasms  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
follicular dendritic cell sarcoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
growth hormone insensitivity syndrome with immune dysregulation 1  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (IEP)
hepatocellular carcinoma  (ISO)
hyper IgE recurrent infection syndrome 1  (ISO,ISS)
hyper IgE syndrome  (ISO)
Hyperalgesia  (IMP)
hyperuricemia  (IDA)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISS)
irritant dermatitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (IDA)
Liver Neoplasms  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
lymphoproliferative syndrome  (ISO)
medulloblastoma  (ISO)
Memory Disorders  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA)
middle cerebral artery infarction  (ISO)
Multisystem Autoimmune Disease, Infantile-Onset, 1  (ISO)
Myocardial Reperfusion Injury  (IDA)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neutropenia  (IAGP)
Niemann-Pick disease type C1  (ISO)
obesity  (IDA,ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
periodontitis  (ISO)
peripartum cardiomyopathy  (ISS)
pre-malignant neoplasm  (IEP,ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO,ISS)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA)
Pulmonary Hypertension, Hypoxia-Induced  (IDA)
Pyogenic Granuloma  (ISO)
rectum adenocarcinoma  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IDA)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (IDA)
Sepsis-Associated Encephalopathy  (IDA)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (IEP)
T-cell acute lymphoblastic leukemia  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IDA,IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-Arctigenin  (ISO)
(-)-cotinine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-lobeline  (ISO)
(-)-matairesinol  (ISO)
(-)-selegiline  (ISO)
(20R)-protopanaxadiol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-naphthoquinone  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
25-hydroxycholesterol  (EXP)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
abamectin  (EXP)
acetamide  (EXP)
acetic acid  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
Allylamine  (EXP)
alpinumisoflavone  (ISO)
aluminium hydroxide  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
amidotrizoic acid  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (EXP,ISO)
amphibole asbestos  (EXP)
andrographolide  (ISO)
Anemoside B4  (ISO)
Angoline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atrazine  (ISO)
aucubin  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
baicalin  (ISO)
Bardoxolone methyl  (ISO)
bazedoxifene  (ISO)
bellidifolin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
beraprost  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
beta-Elemonic acid  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
BQ 123  (ISO)
bucladesine  (ISO)
butein  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
capillarisin  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbidopa  (ISO)
carbofuran  (EXP)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carnosine  (ISO)
carrageenan  (EXP)
cefaloridine  (EXP)
celecoxib  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chitin  (ISO)
chlorophyllin  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
ciglitazone  (ISO)
Cirsimarin  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colistin  (EXP)
columbamine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumermycin A1  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocin-1  (ISO)
Cryptotanshinone  (ISO)
crystal violet  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanidin cation  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dinaciclib  (ISO)
dinitrogen oxide  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
docebenone  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
emodin  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
eriocitrin  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP)
ethyl methanesulfonate  (ISO)
fisetin  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fraxetin  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
galaxolide  (ISO)
Galiellalactone  (ISO)
Ganoderic acid A  (ISO)
Ganoderic acid C2  (ISO)
Garcinol  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
Ginkgoic acid  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK690693  (ISO)
GW 3965  (EXP)
halothane  (ISO)
hesperetin  (EXP)
hesperidin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (ISO)
Hexamethonium  (EXP,ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
hydroxysafflor yellow A  (ISO)
imiquimod  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
Interferon beta-1b  (ISO)
iomeprol  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoliquiritigenin  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
kurarinol  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (ISO)
L-mimosine  (EXP)
lactucin  (EXP,ISO)
lapatinib  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
limonin  (ISO)
linagliptin  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
loganin  (EXP,ISO)
loliolide  (ISO)
losartan  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lycorine  (ISO)
malaoxon  (EXP)
malathion  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
manumycin A  (ISO)
maslinic acid  (ISO)
masoprocol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
mercury dichloride  (ISO)
mesalamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (EXP)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (ISO)
Methylthiouracil  (ISO)
mevalonic acid  (EXP,ISO)
microcystin-LR  (ISO)
mocetinostat  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
morin  (ISO)
morphine  (ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-phosphocreatine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naringin  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifuroxazide  (EXP)
nimesulide  (ISO)
nitrofen  (EXP)
nitrofurantoin  (EXP,ISO)
nitroglycerin  (EXP)
Nonylphenol  (ISO)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (ISO)
olanzapine  (EXP)
oleanolic acid  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
palmatine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (ISO)
paroxetine  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylpropanolamine  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosphatidic acid  (ISO)
physostigmine  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
Ponicidin  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
Punicalagin  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
reparixin  (ISO)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP)
rimonabant  (ISO)
risperidone  (EXP)
ritodrine  (ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salinomycin  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
solasodine  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
stattic  (EXP,ISO)
staurosporine  (ISO)
stavudine  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
succinic acid  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theobromine  (EXP)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tolcapone  (EXP)
toluene  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
Trachelogenin  (ISO)
trametinib  (ISO)
triadimefon  (EXP)
trichloroethene  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tubastatin A  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (ISO)
tyrphostin B42  (ISO)
U50488  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
verapamil  (EXP)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (EXP)
withaferin A  (ISO)
wogonin  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
astrocyte differentiation  (IEA,ISO,ISS)
cell differentiation  (ISO)
cell population proliferation  (IEA,ISO)
cell surface receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO,TAS)
cell surface receptor signaling pathway via STAT  (ISO)
cellular response to cytokine stimulus  (IDA)
cellular response to hormone stimulus  (ISO)
cellular response to interleukin-17  (IEA,ISO)
cellular response to leptin stimulus  (ISO,ISS)
cellular response to organic cyclic compound  (IDA)
defense response  (IBA)
eating behavior  (IEA,ISO,ISS)
energy homeostasis  (IEA,ISO,ISS)
eye photoreceptor cell differentiation  (ISS)
gene expression  (ISO)
glucose homeostasis  (IEA,ISO,ISS)
growth hormone receptor signaling pathway  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO,ISS)
inflammatory response  (IEA,ISO,ISS)
interleukin-10-mediated signaling pathway  (IEA,ISO)
interleukin-11-mediated signaling pathway  (IEA,ISO)
interleukin-15-mediated signaling pathway  (IEA,ISO)
interleukin-2-mediated signaling pathway  (IEA,ISO)
interleukin-23-mediated signaling pathway  (IEA,ISO)
interleukin-6-mediated signaling pathway  (IEA,ISO,ISS)
interleukin-9-mediated signaling pathway  (IEA,ISO)
intracellular receptor signaling pathway  (IEA,ISO)
leptin-mediated signaling pathway  (IBA,IEA,ISO,ISS)
modulation of chemical synaptic transmission  (EXP,IDA,IMP)
mRNA transcription by RNA polymerase II  (IEA,ISO)
negative regulation of autophagy  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cellular process  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of glycolytic process  (IEA,ISO)
negative regulation of hydrogen peroxide biosynthetic process  (IMP)
negative regulation of inflammatory response  (ISO)
negative regulation of inflammatory response to wounding  (IEA,ISO)
negative regulation of neuron migration  (IEA,ISO)
negative regulation of primary miRNA processing  (IEA,ISO)
negative regulation of stem cell differentiation  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
phosphorylation  (ISO,ISS)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (IGI)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of erythrocyte differentiation  (IEA,ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (IMP)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IGI)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
postsynapse to nucleus signaling pathway  (IDA,IEP)
protein import into nucleus  (IEA,ISO,ISS)
radial glial cell differentiation  (IEA,ISO,ISS)
regulation of cell cycle  (IEA,ISO,ISS)
regulation of cell population proliferation  (IBA)
regulation of cellular response to hypoxia  (IMP)
regulation of DNA-templated transcription  (ISO,ISS)
regulation of feeding behavior  (IEA,ISO,ISS)
regulation of mitochondrial membrane permeability  (IMP)
regulation of multicellular organism growth  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISS)
response to cytokine  (IDA)
response to estradiol  (IEA,IEP,ISO)
response to ethanol  (IEP)
response to hypoxia  (IEP)
response to ischemia  (IMP)
response to leptin  (ISO,ISS)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IBA,IEP)
response to xenobiotic stimulus  (IEP)
retinal rod cell differentiation  (IEA,ISO)
sexual reproduction  (IEA,ISO,ISS)
somatic stem cell population maintenance  (IEA,ISO)
T-helper 17 cell lineage commitment  (IEA,ISO,ISS)
T-helper 17 type immune response  (ISO)
temperature homeostasis  (IEA,ISO,ISS)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. Prevention of hypovolemic circulatory collapse by IL-6 activated stat3. Alten JA, etal., PLoS ONE. 2008 Feb 13;3(2):e1605.
3. NF-kappaB and STAT3 inhibition as a therapeutic strategy in psoriasis: in vitro and in vivo effects of BTH. Andres RM, etal., J Invest Dermatol. 2013 Oct;133(10):2362-71. doi: 10.1038/jid.2013.182. Epub 2013 Apr 17.
4. Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period. Anhe GF, etal., J Endocrinol. 2007 Oct;195(1):17-27.
5. Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. Arambasic J, etal., IUBMB Life. 2010 Mar;62(3):227-36.
6. STAT3 deletion sensitizes cells to oxidative stress. Barry SP, etal., Biochem Biophys Res Commun. 2009 Jul 31;385(3):324-9. doi: 10.1016/j.bbrc.2009.05.051. Epub 2009 May 18.
7. The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Boengler K, etal., Curr Pharm Des. 2013;19(39):6890-5.
8. ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Bong YS, etal., Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17305-10. Epub 2007 Oct 22.
9. Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1. Booz GW, etal., Mol Cell Biochem 2002 Nov;240(1-2):39-46.
10. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Cao H, etal., Circ Res. 2006 Apr 14;98(7):913-22. Epub 2006 Mar 9.
11. Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease. Cenit MC, etal., Hum Immunol. 2013 Feb;74(2):230-3. doi: 10.1016/j.humimm.2012.10.019. Epub 2012 Nov 2.
12. SH2B1beta interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. Chang YJ, etal., Mol Cell Biol. 2014 Mar;34(6):1003-19. doi: 10.1128/MCB.00940-13. Epub 2014 Jan 6.
13. [Expressions of VEGF/VEGFRs and activation of STATs in ovarian carcinoma] Chen BY, etal., Zhonghua Zhong Liu Za Zhi. 2005 Jan;27(1):33-7.
14. Stat3 activation in human endometrial and cervical cancers. Chen CL, etal., Br J Cancer. 2007 Feb 26;96(4):591-9.
15. Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. Chen JR, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):50-9. Epub 2007 Oct 4.
16. Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia. Chen N, etal., Oncol Rep. 2018 Jun;39(6):3064-3072. doi: 10.3892/or.2018.6367. Epub 2018 Apr 12.
17. Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. Chen SY, etal., J Cutan Pathol. 2008 Aug;35(8):722-30.
18. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Chen Y, etal., Diabetologia. 2012 Sep;55(9):2533-45. doi: 10.1007/s00125-012-2594-1. Epub 2012 Jun 4.
19. Clinicopathologic and prognostic significance of VEGF, JAK2 and STAT3 in patients with nasopharyngeal carcinoma. Cheng JZ, etal., Cancer Cell Int. 2018 Aug 13;18:110. doi: 10.1186/s12935-018-0605-0. eCollection 2018.
20. Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Chiba T, etal., Mol Psychiatry. 2009 Feb;14(2):206-22. doi: 10.1038/mp.2008.105. Epub 2008 Sep 23.
21. Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Choi JS, etal., Glia 2003 Feb;41(3):237-46.
22. Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells. Chung H, etal., J Endocrinol. 2013 Jun 1;218(1):49-59. doi: 10.1530/JOE-13-0045. Print 2013 Jul.
23. Stat3 activation in prostatic carcinomas. Dhir R, etal., Prostate. 2002 Jun 1;51(4):241-6.
24. Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target. El-Hashemite N and Kwiatkowski DJ, Am J Respir Cell Mol Biol. 2005 Sep;33(3):227-30. Epub 2005 Jun 30.
25. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. Farooqi IS, etal., N Engl J Med. 2007 Jan 18;356(3):237-47.
26. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
27. Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population. Ferguson LR, etal., Mutat Res. 2010 Aug 7;690(1-2):108-15. Epub 2010 Jan 28.
28. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
29. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
30. Opposite nuclear level and binding activity of STAT5B and STAT3 proteins with rat haptoglobin gene under normal and turpentine induced acute phase conditions. Grigorov I, etal., Mol Biol Rep 2001;28(4):217-22.
31. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
32. MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. Halkein J, etal., J Clin Invest. 2013 May 1;123(5):2143-54. doi: 10.1172/JCI64365. Epub 2013 Apr 24.
33. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. Harris TJ, etal., J Immunol. 2007 Oct 1;179(7):4313-7.
34. Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: a study of incidence and its association with pathological features and clinical outcome. Horiguchi A, etal., J Urol. 2002 Aug;168(2):762-5.
35. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
36. JAK2 and STAT3 polymorphisms in a Han Chinese population with Behcet's disease. Hu K, etal., Invest Ophthalmol Vis Sci. 2012 Jan 31;53(1):538-41. Print 2012 Jan.
37. Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway. Huang T, etal., Oxid Med Cell Longev. 2019 Jul 15;2019:5813985. doi: 10.1155/2019/5813985. eCollection 2019.
38. IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension. Ishibashi T, etal., Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2315123121. doi: 10.1073/pnas.2315123121. Epub 2024 Apr 11.
39. STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. Ito N, etal., J Clin Oncol. 2007 Jul 1;25(19):2785-91.
40. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Izumi-Nagai K, etal., Am J Pathol. 2007 Jun;170(6):2149-58.
41. Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients. Jakiela B, etal., Rheumatology (Oxford). 2012 Jul 5.
42. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T cell large granular lymphocyte leukemia. Jerez A, etal., Blood. 2012 Aug 2.
43. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-kappaB signaling pathways. Jia Y, etal., PLoS One. 2011;6(10):e27006. Epub 2011 Oct 31.
44. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Jing N, etal., Cancer Res. 2004 Sep 15;64(18):6603-9.
45. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
46. Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis. Kataoka K, etal., Carcinogenesis. 2008 Jun;29(6):1108-14. doi: 10.1093/carcin/bgn061. Epub 2008 May 2.
47. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Khomenko T, etal., Dig Dis Sci. 2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3.
48. Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis. Kim DJ, etal., Oncogene. 2009 Feb 19;28(7):950-60. doi: 10.1038/onc.2008.453. Epub 2009 Jan 12.
49. JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. Kim OS, etal., J Biol Chem 2002 Oct 25;277(43):40594-601. Epub 2002 Aug 20.
50. Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3. Kong F, etal., Shock 2002 Oct;18(4):374-9.
51. Somatic STAT3 mutations in large granular lymphocytic leukemia. Koskela HL, etal., N Engl J Med. 2012 May 17;366(20):1905-13.
52. Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting. Kurosaka M and Machida S, Cell Prolif. 2013 Aug;46(4):365-73. doi: 10.1111/cpr.12045.
53. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
54. Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression. Lee CS, etal., J Ethnopharmacol. 2011 Jun 1;135(3):747-53. doi: 10.1016/j.jep.2011.04.009. Epub 2011 Apr 12.
55. Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. Lejeune D, etal., J Biol Chem 2002 Sep 13;277(37):33676-82. Epub 2002 Jun 26.
56. FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers. Leng Y, etal., Mol Psychiatry. 2015 Feb;20(2):215-23. doi: 10.1038/mp.2013.192. Epub 2014 Jan 28.
57. Mangiferin ameliorates Porphyromonas gingivalis-induced experimental periodontitis by inhibiting phosphorylation of nuclear factor-κB and Janus kinase 1-signal transducer and activator of transcription signaling pathways. Li H, etal., J Periodontal Res. 2017 Feb;52(1):1-7. doi: 10.1111/jre.12360. Epub 2016 Jan 30.
58. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
59. Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells. Li X, etal., PLoS One. 2012;7(10):e47600. doi: 10.1371/journal.pone.0047600. Epub 2012 Oct 19.
60. Effects of propofol on invasion and migration of colon cancer cells and JAK2/STAT3 signaling pathway. Liang B and Dong T, Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28;45(3):290-296. doi: 10.11817/j.issn.1672-7347.2020.180704.
61. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
62. Ilex paraguariensis (yerba mate) improves endocrine and metabolic disorders in obese rats primed by early weaning. Lima Nda S, etal., Eur J Nutr. 2014 Feb;53(1):73-82. doi: 10.1007/s00394-013-0500-3. Epub 2013 Feb 9.
63. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Ling X, etal., Cancer Res. 2007 May 1;67(9):4210-8.
64. Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma. Liu HW, etal., Cancers (Basel). 2019 Nov 27;11(12). pii: cancers11121888. doi: 10.3390/cancers11121888.
65. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Liu JR, etal., Pathol Res Pract. 2015 Jun;211(6):426-34. doi: 10.1016/j.prp.2015.01.007. Epub 2015 Jan 24.
66. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. Liu X, etal., J Immunol. 2008 May 1;180(9):6070-6.
67. Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. Liu X, etal., PLoS One. 2013 Oct 3;8(10):e75804. doi: 10.1371/journal.pone.0075804. eCollection 2013.
68. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Liu YF, etal., Int J Mol Sci. 2015 Jan 12;16(1):1576-89. doi: 10.3390/ijms16011576.
69. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
70. Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. Ma H, etal., J Mol Cell Cardiol. 2012 Jun;52(6):1282-90. doi: 10.1016/j.yjmcc.2012.02.011. Epub 2012 Mar 6.
71. Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli. Manukyan I, etal., J Cell Mol Med. 2010 Jun;14(6B):1707-16. doi: 10.1111/j.1582-4934.2009.00804.x. Epub 2009 Jun 16.
72. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Mashili F, etal., Diabetes. 2013 Feb;62(2):457-65. doi: 10.2337/db12-0337. Epub 2012 Oct 5.
73. Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinoma. Masuda M, etal., Oral Oncol. 2007 Sep;43(8):785-90. Epub 2006 Dec 13.
74. TNF-a-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between I¿B-NF¿B and JAK-STAT3 pathways. Matsumoto J, etal., Brain Res. 2018 Aug 1;1692:34-44. doi: 10.1016/j.brainres.2018.04.023. Epub 2018 Apr 24.
75. Expression and activation of STAT3 in ischemia-induced retinopathy. Mechoulam H and Pierce EA, Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4409-16.
76. Interleukin-17 Signaling in Inflammatory, Kupffer, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice. Meng F, etal., Gastroenterology. 2012 Jun 8.
77. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
78. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
79. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Minegishi Y, etal., Nature. 2007 Aug 30;448(7157):1058-62. Epub 2007 Aug 5.
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PMID:33300076   PMID:33380723   PMID:33414426   PMID:33522063   PMID:33729996   PMID:33757547   PMID:34016951   PMID:34081793   PMID:34125331   PMID:34296288   PMID:34423720   PMID:34516361  
PMID:34521353   PMID:34530740   PMID:34699606   PMID:34699790   PMID:34731364   PMID:34785448   PMID:35042436   PMID:35122774   PMID:35124149   PMID:35153255   PMID:35655056   PMID:35779691  
PMID:35871214   PMID:35882013   PMID:36252138   PMID:36446389   PMID:36482855   PMID:36521373   PMID:36579750   PMID:36794521   PMID:36796734   PMID:36890454   PMID:36912917   PMID:37062956  
PMID:37162107   PMID:37210406   PMID:37641874   PMID:37759514   PMID:37856074   PMID:37961034   PMID:38001489   PMID:38040660   PMID:38054824   PMID:38154546   PMID:38306778   PMID:38733520  
PMID:38796983  


Genomics

Comparative Map Data
Stat3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,311,528 - 86,363,513 (-)NCBIGRCr8
mRatBN7.21085,811,206 - 85,863,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,847,511 - 90,899,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,326,207 - 90,377,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,719,368 - 85,771,150 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
STAT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,313,324 - 42,388,442 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,313,324 - 42,388,568 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,465,342 - 40,540,460 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,718,869 - 37,794,039 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,718,868 - 37,794,039NCBI
Celera1737,120,227 - 37,194,843 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,230,024 - 36,304,785 (-)NCBIHuRef
CHM1_11740,701,045 - 40,776,137 (-)NCBICHM1_1
T2T-CHM13v2.01743,169,811 - 43,244,652 (-)NCBIT2T-CHM13v2.0
Stat3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,777,632 - 100,830,447 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,775,924 - 100,830,366 (-)EnsemblGRCm39 Ensembl
GRCm3811100,886,806 - 100,939,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,885,098 - 100,939,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,748,124 - 100,800,825 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,702,900 - 100,755,601 (-)NCBIMGSCv36mm8
MGSCv3611101,663,341 - 101,716,042 (-)NCBIMGSCv36mm8
Celera11112,235,347 - 112,235,602 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.82NCBI
Stat3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,319,904 - 16,357,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,320,326 - 16,348,505 (-)NCBIChiLan1.0ChiLan1.0
STAT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,594,115 - 22,671,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,486,658 - 24,561,894 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,928,689 - 15,003,644 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,152,358 - 15,227,084 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,152,358 - 15,227,067 (+)Ensemblpanpan1.1panPan2
STAT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,539,660 - 20,614,631 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,539,697 - 20,612,672 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,001,678 - 20,076,249 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,258,611 - 21,334,353 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,258,632 - 21,334,351 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,044,250 - 20,119,519 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,309,625 - 20,386,466 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,413,942 - 20,489,100 (+)NCBIUU_Cfam_GSD_1.0
Stat3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,877,467 - 19,955,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,117,290 - 17,178,402 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,119,189 - 17,178,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,407,233 - 20,472,992 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,407,316 - 20,471,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,709,840 - 20,775,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,877,884 - 63,957,894 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,922,862 - 63,957,984 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,685,072 - 34,769,191 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,648,080 - 1,681,200 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,648,235 - 1,680,788 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stat3
220 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:674
Count of miRNA genes:285
Interacting mature miRNAs:370
Transcripts:ENSRNOT00000026760
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
BF417681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,853,211 - 85,853,362 (+)MAPPERmRatBN7.2
Rnor_6.01088,832,388 - 88,832,538NCBIRnor6.0
Rnor_5.01088,628,605 - 88,628,755UniSTSRnor5.0
RGSC_v3.41089,863,124 - 89,863,274UniSTSRGSC3.4
Celera1084,570,986 - 84,571,136UniSTS
RH 3.4 Map10860.3UniSTS
Cytogenetic Map10q32.1UniSTS
PMC303343P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,814,078 - 85,814,309 (+)MAPPERmRatBN7.2
Rnor_6.01088,793,267 - 88,793,497NCBIRnor6.0
Rnor_5.01088,587,471 - 88,587,701UniSTSRnor5.0
RGSC_v3.41089,823,939 - 89,824,169UniSTSRGSC3.4
Celera1084,531,915 - 84,532,145UniSTS
Cytogenetic Map10q32.1UniSTS
RH94819  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,812,579 - 85,812,822 (+)MAPPERmRatBN7.2
Rnor_6.01088,791,770 - 88,792,012NCBIRnor6.0
Rnor_5.01088,585,974 - 88,586,216UniSTSRnor5.0
RGSC_v3.41089,822,442 - 89,822,684UniSTSRGSC3.4
Celera1084,530,418 - 84,530,660UniSTS
RH 3.4 Map10837.0UniSTS
Cytogenetic Map10q32.1UniSTS
RH143302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,812,832 - 85,812,936 (+)MAPPERmRatBN7.2
Rnor_6.01088,792,023 - 88,792,126NCBIRnor6.0
Rnor_5.01088,586,227 - 88,586,330UniSTSRnor5.0
RGSC_v3.41089,822,695 - 89,822,798UniSTSRGSC3.4
Celera1084,530,671 - 84,530,774UniSTS
RH 3.4 Map10860.9UniSTS
Cytogenetic Map10q32.1UniSTS
PMC317074P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,814,078 - 85,814,309 (+)MAPPERmRatBN7.2
Rnor_6.01088,793,267 - 88,793,497NCBIRnor6.0
Rnor_5.01088,587,471 - 88,587,701UniSTSRnor5.0
RGSC_v3.41089,823,939 - 89,824,169UniSTSRGSC3.4
Celera1084,531,915 - 84,532,145UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001430046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU477503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU477504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026760   ⟹   ENSRNOP00000026760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)Ensembl
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119716   ⟹   ENSRNOP00000092154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,811,218 - 85,837,739 (-)Ensembl
RefSeq Acc Id: NM_012747   ⟹   NP_036879
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,311,533 - 86,363,359 (-)NCBI
mRatBN7.21085,811,216 - 85,863,057 (-)NCBI
Rnor_6.01088,790,406 - 88,842,233 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
RGSC_v3.41089,821,078 - 89,872,970 (-)RGD
Celera1084,529,054 - 84,580,831 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247257   ⟹   XP_006247319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,311,528 - 86,363,513 (-)NCBI
mRatBN7.21085,811,206 - 85,836,607 (-)NCBI
Rnor_6.01088,790,401 - 88,842,263 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247258   ⟹   XP_006247320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,313,347 - 86,363,513 (-)NCBI
mRatBN7.21085,811,206 - 85,836,607 (-)NCBI
Rnor_6.01088,790,401 - 88,842,263 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247259   ⟹   XP_006247321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,313,347 - 86,363,513 (-)NCBI
mRatBN7.21085,811,206 - 85,836,607 (-)NCBI
Rnor_6.01088,790,401 - 88,842,263 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036879   ⟸   NM_012747
- UniProtKB: P52631 (UniProtKB/Swiss-Prot),   A6HJ64 (UniProtKB/TrEMBL),   A0A8I6GJJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247321   ⟸   XM_006247259
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006247320   ⟸   XM_006247258
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006247319   ⟸   XM_006247257
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000026760   ⟸   ENSRNOT00000026760
Ensembl Acc Id: ENSRNOP00000092154   ⟸   ENSRNOT00000119716
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52631-F1-model_v2 AlphaFold P52631 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697735
Promoter ID:EPDNEW_R8260
Type:initiation region
Name:Stat3_1
Description:signal transducer and activator of transcription 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,842,214 - 88,842,274EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3772 AgrOrtholog
BioCyc Gene G2FUF-23210 BioCyc
Ensembl Genes ENSRNOG00000019742 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032275 UniProtKB/Swiss-Prot
  ENSRNOG00060012887 UniProtKB/Swiss-Prot
  ENSRNOG00065029490 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026760.5 UniProtKB/Swiss-Prot
  ENSRNOT00000119716.1 UniProtKB/TrEMBL
  ENSRNOT00055055737 UniProtKB/Swiss-Prot
  ENSRNOT00060021941 UniProtKB/Swiss-Prot
  ENSRNOT00065050949 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110655 IMAGE-MGC_LOAD
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT3_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93551 IMAGE-MGC_LOAD
NCBI Gene 25125 ENTREZGENE
PANTHER PTHR11801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB STAT3 RGD
PhenoGen Stat3 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019742 RatGTEx
  ENSRNOG00055032275 RatGTEx
  ENSRNOG00060012887 RatGTEx
  ENSRNOG00065029490 RatGTEx
SMART STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229750
UniProt A0A8I6GJJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6HJ64 ENTREZGENE, UniProtKB/TrEMBL
  P52631 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Stat3  signal transducer and activator of transcription 3  Stat3  signal transducer and activator of transcription 3 (acute-phase response factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Stat3  signal transducer and activator of transcription 3 (acute-phase response factor)  Stat3  signal transducer and activator of transcription 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Stat3  signal transducer and activator of transcription 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function transcription factor that binds to the interleukin-6 (IL-6)-responsive elements in the promoters of acute-phase protein genes 61073
gene_process involved in the gp130-mediated signaling pathway 61073
gene_process persistent phosphorylation in the hypothalamus is correlated with leptin-induced leptin resistance 625717