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ONTOLOGY REPORT - ANNOTATIONS

Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism


show annotations for term's descendants           Sort by:
hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cycs cytochrome c, somatic acts_upstream_of_or_within ISO (PMID:16757556) RGD PMID:16757556 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyct cytochrome c, testis acts_upstream_of_or_within ISO (PMID:16757556) RGD PMID:16757556 NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:1914061 (PMID:23770197) RGD PMID:23770197 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO MGI:2384861 (PMID:23770197) RGD PMID:23770197 NCBI chr 3:109,245,337...109,249,055
Ensembl chr 3:109,245,476...109,248,968 		JBrowse link
G Egfr epidermal growth factor receptor IEP RGD PMID:21258655 RGD:5131481 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Nox1 NADPH oxidase 1 involved_in ISO
IEA		 (PMID:11331784)
GO_REF:0000107		 RGD
Ensembl		 PMID:11331784 GO_REF:0000107 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within		 ISO (PMID:24567322)
MGI:3514165 (PMID:17766438)		 RGD PMID:17766438 PMID:24567322 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO MGI:2668456 (PMID:15259009), (PMID:17325201) RGD PMID:15259009 PMID:17325201 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:16716903 RGD:1580833 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase involved_in ISO (PMID:18379038) RGD PMID:18379038 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Txn1 thioredoxin 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q99497 (PMID:22492997)		 Ensembl
RGD		 PMID:22492997 GO_REF:0000107 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO
IEA
ISS		 (PMID:14749723)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:14749723 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:32169171)		 Ensembl
UniProt
RGD		 PMID:32169171 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Cyba cytochrome b-245 alpha chain involved_in IMP PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain acts_upstream_of_or_within ISO MGI:1857284 (PMID:15258578) RGD PMID:15258578 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 acts_upstream_of_or_within ISO MGI:2182307 (PMID:14980704) RGD PMID:14980704 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2182351 (PMID:14980704)		 Ensembl
RGD		 PMID:14980704 GO_REF:0000107 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Duox1 dual oxidase 1 involved_in ISO
IEA		 UniProtKB:Q1HG43 (PMID:19339556), (PMID:22814254)
GO_REF:0000107		 RGD
Ensembl		 PMID:19339556 PMID:22814254 GO_REF:0000107 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 involved_in ISO UniProtKB:Q1HG44 (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) RGD PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (PMID:15258578) RGD PMID:15258578 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in		 IMP
ISO
IEA
ISS
IDA		 MGI:1857873 (PMID:14679182)
GO_REF:0000107
(PMID:15544046)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:14679182 PMID:15544046 PMID:15880490 PMID:12514262 PMID:10640619 GO_REF:0000024 GO_REF:0000107, RGD:1581090, RGD:634854, RGD:1601266 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 IDA RGD PMID:15642720 RGD:2291946 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16945374)		 Ensembl
RGD		 PMID:16945374 GO_REF:0000107 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Cat catalase acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
IDA		 MGI:3051232|MGI:3053604 (PMID:10617683), (PMID:15178682), (PMID:17275685), (PMID:642030), (PMID:9600348)
GO_REF:0000033
GO_REF:0000043
(PMID:18379038)		 RGD
GO_Central
UniProt		 PMID:642030 PMID:9600348 PMID:10617683 PMID:15178682 PMID:17275685 More... GO_REF:0000033 GO_REF:0000043, RGD:1358492, RGD:2292202 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Duox1 dual oxidase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:15203190)
MGI:2158814|MGI:2388705|MGI:3589261 (PMID:10754271), (PMID:10915565), (PMID:11545230), (PMID:15182862), (PMID:15827346), (PMID:9788901)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... GO_REF:0000033 GO_REF:0000107 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:10617683)		 GO_Central
RGD		 PMID:10617683 GO_REF:0000033 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 involved_in ISO
IBA		 (PMID:19740759)
GO_REF:0000033		 RGD
GO_Central		 PMID:19740759 GO_REF:0000033 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 involved_in ISO
IBA		 (PMID:19740759)
GO_REF:0000033		 RGD
GO_Central		 PMID:19740759 GO_REF:0000033 NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481 		JBrowse link
G Hbb hemoglobin subunit beta involved_in ISO
IBA		 (PMID:19740759)
GO_REF:0000033		 RGD
GO_Central		 PMID:19740759 GO_REF:0000033 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hbb-b2 hemoglobin, beta adult minor chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,243,696...158,245,076
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hbb-bs hemoglobin, beta adult s chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,218,356...158,219,741
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hbbl1 hemoglobin subunit beta like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,236,972...158,238,348
Ensembl chr 1:158,120,200...158,252,012
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hbe1 hemoglobin subunit epsilon 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,282,931...158,458,855
Ensembl chr 1:158,282,936...158,284,391 		JBrowse link
G Hbe2 hemoglobin, epsilon 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,279,285...158,280,913
Ensembl chr 1:158,279,285...158,280,913 		JBrowse link
G Hbg1 hemoglobin subunit gamma 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,271,871...158,273,426
Ensembl chr 1:158,271,873...158,273,425 		JBrowse link
G Hbq1b hemoglobin subunit theta 1B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:15,334,293...15,336,061
Ensembl chr10:15,320,762...15,321,397
Ensembl chr10:15,320,762...15,321,397 		JBrowse link
G Hbz hemoglobin subunit zeta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:15,343,821...15,345,301
Ensembl chr10:15,343,831...15,345,312 		JBrowse link
G Mpo myeloperoxidase involved_in
acts_upstream_of_or_within		 ISO (PMID:10772654)
MGI:2176344 (PMID:10085024)
(PMID:11907569)		 RGD PMID:10085024 PMID:10772654 PMID:11907569 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Prdx1 peroxiredoxin 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:18606987)
GO_REF:0000033
(PMID:11986303)		 RGD
GO_Central		 PMID:11986303 PMID:18606987 GO_REF:0000033 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx1l1 peroxiredoxin 1-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:193,602,142...193,603,085
Ensembl chr 2:193,602,121...193,603,084 		JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:2668456 (PMID:15902258)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:15902258 GO_REF:0000033 GO_REF:0000107 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx3 peroxiredoxin 3 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:18195003)
GO_REF:0000033
GO_REF:0000107
(PMID:7733872)		 RGD
GO_Central
Ensembl		 PMID:7733872 PMID:18195003 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Prdx4 peroxiredoxin 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Prdx5 peroxiredoxin 5 involved_in ISO
IBA		 (PMID:10514471)
GO_REF:0000033		 RGD
GO_Central		 PMID:10514471 GO_REF:0000033 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268 		JBrowse link
G Prdx6 peroxiredoxin 6 IDA RGD PMID:8641418 RGD:729495 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Pxdn peroxidasin involved_in ISO (PMID:18929642) RGD PMID:18929642 NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345 		JBrowse link
G Tpo thyroid peroxidase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Txnrd1 thioredoxin reductase 1 IMP RGD PMID:10849437 RGD:634378 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649 		JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hp haptoglobin involved_in ISO (PMID:19740759) RGD PMID:19740759 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Mt3 metallothionein 3 IDA RGD PMID:12058024 RGD:625483 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11991626 RGD:10003093 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) RGD PMID:22814254 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268), (PMID:22814254) RGD PMID:16651268 PMID:22814254 NCBI chr 3:109,245,337...109,249,055
Ensembl chr 3:109,245,476...109,248,968 		JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Nox4 NADPH oxidase 4 IMP RGD PMID:27279484 RGD:151347625 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:20529999 RGD:27095884 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615 		JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase IMP RGD PMID:24722990 RGD:13513981 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823 		JBrowse link
G Snca synuclein alpha involved_in ISO
IEA		 (PMID:23507046)
GO_REF:0000107		 RGD
Ensembl		 PMID:23507046 GO_REF:0000107 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor IDA in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Noxa1 NADPH oxidase activator 1 involved_in ISO (PMID:16636067) RGD PMID:16636067 NCBI chr 3:7,895,488...7,907,011
Ensembl chr 3:7,895,488...7,905,967 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (MGI:5558956|PMID:24553947) RGD PMID:24553947 MGI:5558956 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2668456 (PMID:17325201)		 Ensembl
RGD		 PMID:17325201 GO_REF:0000107 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19870
    cellular process 18312
      cellular metabolic process 9670
        reactive oxygen species metabolic process 268
          hydrogen peroxide metabolic process 61
            detoxification of hydrogen peroxide + 3
            hydrogen peroxide biosynthetic process + 21
            hydrogen peroxide catabolic process + 33
            negative regulation of hydrogen peroxide metabolic process + 9
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 21
paths to the root