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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism



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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cycs cytochrome c, somatic acts_upstream_of_or_within ISO (MGI:3652666|PMID:16757556) RGD PMID:16757556 MGI:3652666 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyct cytochrome c, testis acts_upstream_of_or_within ISO (MGI:3652666|PMID:16757556) RGD PMID:16757556 MGI:3652666 NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
JBrowse link
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:1914061 (MGI:5544173|PMID:23770197) RGD PMID:23770197 MGI:5544173 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO MGI:2384861 (MGI:5544173|PMID:23770197) RGD PMID:23770197 MGI:5544173 NCBI chr 3:109,245,476...109,248,844
Ensembl chr 3:109,245,476...109,248,968
JBrowse link
G Egfr epidermal growth factor receptor IEP RGD PMID:21258655 RGD:5131481 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Nox1 NADPH oxidase 1 involved_in ISO
IEA
(PMID:11331784)
GO_REF:0000107
RGD
Ensembl
PMID:11331784 GO_REF:0000107 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:20969476), (PMID:24567322)
MGI:3514165 (MGI:3723371|PMID:17766438)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:17766438 PMID:20969476 PMID:24567322 GO_REF:0000024 MGI:3723371 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO MGI:2668456 (MGI:3050700|PMID:15259009), (MGI:3758374|PMID:17325201) RGD PMID:15259009 PMID:17325201 MGI:3050700 MGI:3758374 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:16716903 RGD:1580833 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase involved_in ISO
IEA
(PMID:18379038)
GO_REF:0000107
RGD
Ensembl
PMID:18379038 GO_REF:0000107 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:32169171)
Ensembl
UniProt
RGD
PMID:32169171 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Cyba cytochrome b-245 alpha chain involved_in IMP PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain acts_upstream_of_or_within ISO MGI:1857284 (MGI:3050718|PMID:15258578) RGD PMID:15258578 MGI:3050718 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 acts_upstream_of_or_within ISO MGI:2182307 (MGI:3037497|PMID:14980704) RGD PMID:14980704 MGI:3037497 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 acts_upstream_of_or_within ISO MGI:2182351 (MGI:3037497|PMID:14980704) RGD PMID:14980704 MGI:3037497 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Duox1 dual oxidase 1 involved_in ISO
IEA
UniProtKB:Q1HG43 (PMID:19339556), (PMID:22814254)
GO_REF:0000107
RGD
Ensembl
PMID:19339556 PMID:22814254 GO_REF:0000107 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
JBrowse link
G Duox2 dual oxidase 2 involved_in ISO
IEA
UniProtKB:Q1HG44 (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904)
GO_REF:0000002
RGD
InterPro
PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 GO_REF:0000002 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (MGI:3050718|PMID:15258578) RGD PMID:15258578 MGI:3050718 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in
IMP
ISO
ISS
IDA
MGI:1857873 (MGI:2682495|PMID:14679182)
(PMID:15544046)
GO_REF:0000024
RGD
UniProt
PMID:14679182 PMID:15544046 PMID:15880490 PMID:10640619 PMID:12514262 GO_REF:0000024 MGI:2682495, RGD:1581090, RGD:1601266, RGD:634854 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 IDA RGD PMID:15642720 RGD:2291946 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16945374)
Ensembl
RGD
PMID:16945374 GO_REF:0000107 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Cat catalase involved_in
acts_upstream_of_or_within
IMP
IBA
ISO
IDA
PMID:21873635
MGI:3051232|MGI:3053604 (MGI:1203408|PMID:9600348), (MGI:1352605|PMID:10617683), (MGI:3050704|PMID:15178682), (MGI:3698896|PMID:17275685), (MGI:54448|PMID:642030)
(PMID:18379038)
RGD PMID:642030 PMID:9600348 PMID:10617683 PMID:15178682 PMID:17275685 More... MGI:1203408 MGI:1352605 MGI:3050704 MGI:3698896 MGI:54448, RGD:1358492, RGD:13792537, RGD:2292202 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Duox1 dual oxidase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
JBrowse link
G Duox2 dual oxidase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Gpx1 glutathione peroxidase 1 acts_upstream_of_or_within
involved_in
IDA
ISO
IEA
IBA
MGI:2158814|MGI:2388705|MGI:3589261 (MGI:1314762|PMID:9788901), (MGI:1858834|PMID:10754271), (MGI:3044494|PMID:15182862), (MGI:3612610|PMID:15827346), (MGI:3664695|PMID:11545230), (MGI:3691391|PMID:10915565)
GO_REF:0000107
PMID:21873635
(PMID:15203190)
RGD
Ensembl
PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... GO_REF:0000107 MGI:1314762 MGI:1858834 MGI:3044494 MGI:3612610 MGI:3664695 MGI:3691391, RGD:1624364, RGD:13792537 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx3 glutathione peroxidase 3 acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:1352605|PMID:10617683)
PMID:21873635
RGD PMID:10617683 PMID:16140890 PMID:21873635 MGI:1352605, RGD:1624364, RGD:13792537 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 involved_in IBA
ISO
PMID:21873635
(PMID:19740759)
RGD PMID:19740759 PMID:21873635 RGD:13792537 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 involved_in IBA
ISO
PMID:21873635
(PMID:19740759)
RGD PMID:19740759 PMID:21873635 RGD:13792537 NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481
JBrowse link
G Hbb hemoglobin subunit beta involved_in IBA
ISO
PMID:21873635
(PMID:19740759)
RGD PMID:19740759 PMID:21873635 RGD:13792537 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hbb-bs hemoglobin, beta adult s chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:158,218,356...158,219,722
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hbe1 hemoglobin subunit epsilon 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:158,282,931...158,458,855
Ensembl chr 1:158,282,936...158,284,391
JBrowse link
G Hbe2 hemoglobin, epsilon 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:158,279,285...158,280,913
Ensembl chr 1:158,279,285...158,280,913
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:158,271,993...158,273,371
Ensembl chr 1:158,271,873...158,273,425
JBrowse link
G Hbq1b hemoglobin subunit theta 1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:15,334,293...15,336,061
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hbz hemoglobin subunit zeta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:15,343,821...15,345,301
Ensembl chr10:15,343,831...15,345,312
JBrowse link
G LOC100134871 beta globin minor gene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:158,236,972...158,238,348
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Mpo myeloperoxidase acts_upstream_of_or_within
involved_in
ISO MGI:2176344 (MGI:1333719|PMID:10085024)
(PMID:11907569)
(PMID:10772654)
RGD PMID:10085024 PMID:10772654 PMID:11907569 MGI:1333719 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Prdx1 peroxiredoxin 1 involved_in
acts_upstream_of_or_within
ISO (PMID:18606987)
(PMID:11986303)
RGD PMID:11986303 PMID:18606987 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2668456 (MGI:3578713|PMID:15902258)
Ensembl
RGD
PMID:15902258 GO_REF:0000107 MGI:3578713 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prdx3 peroxiredoxin 3 involved_in
acts_upstream_of_or_within
ISO (PMID:18195003)
(PMID:7733872)
RGD PMID:7733872 PMID:18195003 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prdx5 peroxiredoxin 5 involved_in IBA
ISO
PMID:21873635
(PMID:10514471)
RGD PMID:10514471 PMID:21873635 RGD:13792537 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
JBrowse link
G Prdx6 peroxiredoxin 6 IDA RGD PMID:8641418 RGD:729495 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Pxdn peroxidasin involved_in ISO (PMID:18929642) RGD PMID:18929642 NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345
JBrowse link
G Tpo thyroid peroxidase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link
G Txnrd1 thioredoxin reductase 1 IMP RGD PMID:10849437 RGD:634378 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649
JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hp haptoglobin involved_in ISO (PMID:19740759) RGD PMID:19740759 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Mt3 metallothionein 3 IDA RGD PMID:12058024 RGD:625483 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp3 matrix metallopeptidase 3 involved_in ISO
IEA
(PMID:20969476)
GO_REF:0000107
RGD
Ensembl
PMID:20969476 GO_REF:0000107 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11991626 RGD:10003093 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) RGD PMID:22814254 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268), (PMID:22814254) RGD PMID:16651268 PMID:22814254 NCBI chr 3:109,245,476...109,248,844
Ensembl chr 3:109,245,476...109,248,968
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IMP RGD PMID:19306371 RGD:13506652 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:20529999 RGD:27095884 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,470...12,623,615
Ensembl chr10:12,615,190...12,623,615
JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase IMP RGD PMID:24722990 RGD:13513981 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:23507046) RGD PMID:23507046 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor IDA in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Noxa1 NADPH oxidase activator 1 involved_in ISO (PMID:16636067) RGD PMID:16636067 NCBI chr 3:7,895,488...7,907,011
Ensembl chr 3:7,895,488...7,905,967
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (MGI:5558956|PMID:24553947) RGD PMID:24553947 MGI:5558956 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2668456 (MGI:3758374|PMID:17325201)
Ensembl
RGD
PMID:17325201 GO_REF:0000107 MGI:3758374 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    cellular process 18319
      cellular metabolic process 10675
        reactive oxygen species metabolic process 251
          hydrogen peroxide metabolic process 58
            detoxification of hydrogen peroxide + 1
            hydrogen peroxide biosynthetic process + 21
            hydrogen peroxide catabolic process + 30
            negative regulation of hydrogen peroxide metabolic process + 10
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 22
paths to the root