Mpv17l (MPV17 mitochondrial inner membrane protein like) - Rat Genome Database

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Gene: Mpv17l (MPV17 mitochondrial inner membrane protein like) Rattus norvegicus
Analyze
Symbol: Mpv17l
Name: MPV17 mitochondrial inner membrane protein like
RGD ID: 2324483
Description: Predicted to be involved in several processes, including cellular response to reactive oxygen species; negative regulation of hydrogen peroxide biosynthetic process; and negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100362572; LOC103693261; MPV17 mitochondrial membrane protein-like; Mpv17 transgene, kidney disease mutant-like (predicted)-like; uncharacterized LOC103693261
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2101,988,451 - 2,025,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,988,136 - 2,007,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,685,293 - 6,722,135 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01033,843,705 - 33,880,545 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,891,760 - 1,928,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0103,321,488 - 3,359,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl103,321,476 - 3,357,470 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0102,198,456 - 2,240,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4101,655,565 - 1,672,677 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera101,020,550 - 1,057,289 (-)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16631601   PMID:18614015   PMID:20178365   PMID:22306510  


Genomics

Comparative Map Data
Mpv17l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2101,988,451 - 2,025,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,988,136 - 2,007,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,685,293 - 6,722,135 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01033,843,705 - 33,880,545 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,891,760 - 1,928,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0103,321,488 - 3,359,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl103,321,476 - 3,357,470 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0102,198,456 - 2,240,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4101,655,565 - 1,672,677 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera101,020,550 - 1,057,289 (-)NCBICelera
Cytogenetic Map10q11NCBI
MPV17L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,395,754 - 15,413,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1615,395,754 - 15,413,271 (+)EnsemblGRCh38hg38GRCh38
GRCh371615,489,611 - 15,507,128 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,397,137 - 15,411,044 (+)NCBINCBI36Build 36hg18NCBI36
Celera1615,170,072 - 15,184,012 (+)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1614,882,901 - 14,896,979 (+)NCBIHuRef
CHM1_11615,573,943 - 15,587,891 (+)NCBICHM1_1
T2T-CHM13v2.01615,400,550 - 15,418,071 (+)NCBIT2T-CHM13v2.0
Mpv17l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,721,025 - 13,767,483 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,721,025 - 13,767,483 (+)EnsemblGRCm39 Ensembl
GRCm381613,903,161 - 13,949,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,903,161 - 13,949,619 (+)EnsemblGRCm38mm10GRCm38
MGSCv371613,940,788 - 13,949,450 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,854,273 - 13,862,935 (+)NCBIMGSCv36mm8
Celera1614,545,960 - 14,554,599 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.64NCBI
Mpv17l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442238,597 - 283,328 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955442269,382 - 313,056 (+)NCBIChiLan1.0ChiLan1.0
MPV17L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11619,229,918 - 19,262,262 (+)NCBINHGRI_mPanPan1
PanPan1.11615,703,834 - 15,712,232 (+)NCBIpanpan1.1PanPan1.1panPan2
MPV17L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,385,199 - 28,393,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,746,839 - 29,757,055 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,546,545 - 28,556,760 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1628,349,672 - 28,359,880 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,242,054 - 28,250,022 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,647,729 - 28,655,709 (-)NCBIUU_Cfam_GSD_1.0
Mpv17l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,919,182 - 114,934,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365013,017,012 - 3,027,181 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365013,017,071 - 3,028,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPV17L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,427,395 - 7,441,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,423,083 - 7,441,583 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MPV17L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,397,299 - 14,407,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606815,656,812 - 15,668,534 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpv17l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248248,707,145 - 8,722,613 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248248,707,104 - 8,723,649 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpv17l
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000004384
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat

Markers in Region
BI281552  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,235,937 - 25,236,157 (+)MAPPERmRatBN7.2
Rnor_6.0626,599,962 - 26,600,181NCBIRnor6.0
Rnor_5.0636,416,342 - 36,416,561UniSTSRnor5.0
RGSC_v3.4625,214,606 - 25,214,825UniSTSRGSC3.4
Celera624,727,062 - 24,727,281UniSTS
RH 3.4 Map6119.08UniSTS
BE110423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,224,001 - 25,224,207 (+)MAPPERmRatBN7.2
Rnor_6.0626,588,051 - 26,588,256NCBIRnor6.0
Rnor_5.0636,404,755 - 36,404,960UniSTSRnor5.0
RGSC_v3.4625,201,311 - 25,201,516UniSTSRGSC3.4
Celera624,715,084 - 24,715,289UniSTS
RH 3.4 Map693.0UniSTS
MARC_16687-16688:1017861800:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,231,637 - 25,232,402 (+)MAPPERmRatBN7.2
Rnor_6.0626,595,687 - 26,596,451NCBIRnor6.0
Rnor_5.0636,412,391 - 36,413,155UniSTSRnor5.0
RGSC_v3.4625,208,947 - 25,209,711UniSTSRGSC3.4
Celera624,722,720 - 24,723,484UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 24 14
Low 2 24 45 37 37 4 4 50 21 41 5 4
Below cutoff 1 17 8 18 4 6 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004384   ⟹   ENSRNOP00000004384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,989,605 - 2,007,626 (-)Ensembl
Rnor_6.0 Ensembl103,338,808 - 3,357,278 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,353,519 - 3,357,402 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090166   ⟹   ENSRNOP00000074254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,989,605 - 2,007,649 (-)Ensembl
Rnor_6.0 Ensembl103,321,476 - 3,357,470 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093444   ⟹   ENSRNOP00000076186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,989,605 - 2,007,649 (-)Ensembl
Rnor_6.0 Ensembl103,338,880 - 3,353,769 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112675   ⟹   ENSRNOP00000078889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,988,136 - 2,007,649 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115587   ⟹   ENSRNOP00000094538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,988,136 - 2,007,601 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117447   ⟹   ENSRNOP00000095618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,988,136 - 2,007,601 (-)Ensembl
RefSeq Acc Id: NM_001402078   ⟹   NP_001389007
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,988,453 - 2,007,603 (-)NCBI
RefSeq Acc Id: NM_001402079   ⟹   NP_001389008
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,988,453 - 2,025,296 (-)NCBI
RefSeq Acc Id: XM_008767467   ⟹   XP_008765689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,988,451 - 2,007,640 (-)NCBI
Rnor_6.0103,338,751 - 3,359,219 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767468   ⟹   XP_008765690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,988,451 - 2,025,300 (-)NCBI
Rnor_6.0103,321,488 - 3,359,219 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767469   ⟹   XP_008765691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,988,451 - 2,007,350 (-)NCBI
Rnor_6.0103,340,257 - 3,359,219 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767470   ⟹   XP_008765692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,988,451 - 2,007,222 (-)NCBI
Rnor_6.0103,339,167 - 3,359,219 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087605   ⟹   XP_038943533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2102,003,843 - 2,007,642 (-)NCBI
RefSeq Acc Id: XR_005490607
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,988,451 - 2,007,641 (-)NCBI
RefSeq Acc Id: XR_005490608
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,990,927 - 2,007,641 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008765690   ⟸   XM_008767468
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008765689   ⟸   XM_008767467
- Peptide Label: isoform X2
- UniProtKB: A6K4F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765692   ⟸   XM_008767470
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008765691   ⟸   XM_008767469
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000074254   ⟸   ENSRNOT00000090166
RefSeq Acc Id: ENSRNOP00000004384   ⟸   ENSRNOT00000004384
RefSeq Acc Id: ENSRNOP00000076186   ⟸   ENSRNOT00000093444
RefSeq Acc Id: XP_038943533   ⟸   XM_039087605
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K7L3 (UniProtKB/TrEMBL),   A6K4F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078889   ⟸   ENSRNOT00000112675
RefSeq Acc Id: ENSRNOP00000094538   ⟸   ENSRNOT00000115587
RefSeq Acc Id: ENSRNOP00000095618   ⟸   ENSRNOT00000117447
RefSeq Acc Id: NP_001389008   ⟸   NM_001402079
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001389007   ⟸   NM_001402078
- Peptide Label: isoform 1
- UniProtKB: A6K4F3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A908-F1-model_v2 AlphaFold D4A908 1-194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2324483 AgrOrtholog
BioCyc Gene G2FUF-26214 BioCyc
Ensembl Genes ENSRNOG00000003285 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004384.5 UniProtKB/TrEMBL
  ENSRNOP00000074254 ENTREZGENE
  ENSRNOP00000074254.3 UniProtKB/TrEMBL
  ENSRNOP00000076186.2 UniProtKB/TrEMBL
  ENSRNOP00000078889.1 UniProtKB/TrEMBL
  ENSRNOP00000094538.1 UniProtKB/TrEMBL
  ENSRNOP00000095618.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004384.8 UniProtKB/TrEMBL
  ENSRNOT00000090166 ENTREZGENE
  ENSRNOT00000090166.3 UniProtKB/TrEMBL
  ENSRNOT00000093444.2 UniProtKB/TrEMBL
  ENSRNOT00000112675 ENTREZGENE
  ENSRNOT00000112675.1 UniProtKB/TrEMBL
  ENSRNOT00000115587.1 UniProtKB/TrEMBL
  ENSRNOT00000117447.1 UniProtKB/TrEMBL
InterPro Mpv17_PMP22 UniProtKB/TrEMBL
KEGG Report rno:100362572 UniProtKB/TrEMBL
NCBI Gene 100362572 ENTREZGENE
PANTHER MPV17-LIKE PROTEIN UniProtKB/TrEMBL
  Mpv17_PMP22 UniProtKB/TrEMBL
Pfam Mpv17_PMP22 UniProtKB/TrEMBL
PhenoGen Mpv17l PhenoGen
UniProt A0A0G2K7L3 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q697_RAT UniProtKB/TrEMBL
  A0A8I6GL80_RAT UniProtKB/TrEMBL
  A6K4F2 ENTREZGENE, UniProtKB/TrEMBL
  A6K4F3 ENTREZGENE, UniProtKB/TrEMBL
  A6K4F4 ENTREZGENE, UniProtKB/TrEMBL
  D4A908_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mpv17l  MPV17 mitochondrial inner membrane protein like  LOC103693261  uncharacterized LOC103693261  Data Merged 737654 PROVISIONAL
2016-03-22 Mpv17l  MPV17 mitochondrial inner membrane protein like  Mpv17l  MPV17 mitochondrial membrane protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103693261  uncharacterized LOC103693261      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-08-29 Mpv17l  MPV17 mitochondrial membrane protein-like  LOC100362572  Mpv17 transgene, kidney disease mutant-like (predicted)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362572  Mpv17 transgene, kidney disease mutant-like (predicted)-like      Symbol and Name status set to provisional 70820 PROVISIONAL