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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism



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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cycs cytochrome c, somatic acts_upstream_of_or_within ISO (PMID:16757556) RGD PMID:16757556 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyct cytochrome c, testis acts_upstream_of_or_within ISO (PMID:16757556) RGD PMID:16757556 NCBI chr 3:81,697,333...81,704,401 JBrowse link
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:1914061 (PMID:23770197) RGD PMID:23770197 NCBI chr 3:109,249,815...109,260,511 JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO MGI:2384861 (PMID:23770197) RGD PMID:23770197 NCBI chr 3:109,245,337...109,249,055 JBrowse link
G Egfr epidermal growth factor receptor IEP RGD PMID:21258655 RGD:5131481 NCBI chr14:95,378,626...95,551,358 JBrowse link
G Nox1 NADPH oxidase 1 involved_in ISO
IEA
(PMID:11331784)
GO_REF:0000107
RGD
Ensembl
PMID:11331784 GO_REF:0000107 NCBI chr  X:97,279,058...97,332,291 JBrowse link
G Park7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within
ISO (PMID:24567322)
MGI:3514165 (PMID:17766438)
RGD PMID:17766438 PMID:24567322 NCBI chr 5:166,636,551...166,659,825 JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO MGI:2668456 (PMID:15259009), (PMID:17325201) RGD PMID:15259009 PMID:17325201 NCBI chr19:23,180,927...23,186,217 JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:16716903 RGD:1580833 NCBI chr 1:50,043,323...50,050,168 JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase involved_in ISO (PMID:18379038) RGD PMID:18379038 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Txn1 thioredoxin 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:Q99497 (PMID:22492997)
Ensembl
RGD
PMID:22492997 GO_REF:0000107 NCBI chr 5:77,507,455...77,519,685 JBrowse link
detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO
ISS
(PMID:14749723)
GO_REF:0000024
RGD
UniProt
PMID:14749723 GO_REF:0000024 NCBI chr 5:166,636,551...166,659,825 JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:32169171)
Ensembl
UniProt
RGD
PMID:32169171 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,905,083...101,930,136 JBrowse link
G Cyba cytochrome b-245 alpha chain involved_in IMP PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr19:50,487,598...50,495,669 JBrowse link
G Cybb cytochrome b-245 beta chain acts_upstream_of_or_within ISO MGI:1857284 (PMID:15258578) RGD PMID:15258578 NCBI chr  X:16,030,596...16,065,065 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 acts_upstream_of_or_within ISO MGI:2182307 (PMID:14980704) RGD PMID:14980704 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2182351 (PMID:14980704)
Ensembl
RGD
PMID:14980704 GO_REF:0000107 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Duox1 dual oxidase 1 involved_in ISO
IEA
UniProtKB:Q1HG43 (PMID:19339556), (PMID:22814254)
GO_REF:0000107
RGD
Ensembl
PMID:19339556 PMID:22814254 GO_REF:0000107 NCBI chr 3:109,260,526...109,295,588 JBrowse link
G Duox2 dual oxidase 2 involved_in ISO UniProtKB:Q1HG44 (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) RGD PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr 3:129,680,543...129,698,886 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (PMID:15258578) RGD PMID:15258578 NCBI chr12:28,121,816...28,131,080 JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
ISS
IDA
MGI:1857873 (PMID:14679182)
GO_REF:0000107
(PMID:15544046)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:14679182 PMID:15544046 PMID:15880490 PMID:12514262 PMID:10640619 GO_REF:0000024 GO_REF:0000107, RGD:1581090, RGD:634854, RGD:1601266 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sod2 superoxide dismutase 2 IDA RGD PMID:15642720 RGD:2291946 NCBI chr 1:50,043,323...50,050,168 JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16945374)
Ensembl
RGD
PMID:16945374 GO_REF:0000107 NCBI chr 8:55,435,779...55,438,160 JBrowse link
G Cat catalase acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
IDA
MGI:3051232|MGI:3053604 (PMID:10617683), (PMID:15178682), (PMID:17275685), (PMID:642030), (PMID:9600348)
GO_REF:0000033
GO_REF:0000043
(PMID:18379038)
RGD
GO_Central
UniProt
PMID:642030 PMID:9600348 PMID:10617683 PMID:15178682 PMID:17275685 More... GO_REF:0000033 GO_REF:0000043, RGD:1358492, RGD:2292202 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Duox1 dual oxidase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:109,260,526...109,295,588 JBrowse link
G Duox2 dual oxidase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:129,680,543...129,698,886 JBrowse link
G ENSRNOG00000062500 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000063007 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000066051 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000070249 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Gpx1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
(PMID:15203190)
MGI:2158814|MGI:2388705|MGI:3589261 (PMID:10754271), (PMID:10915565), (PMID:11545230), (PMID:15182862), (PMID:15827346), (PMID:9788901)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... GO_REF:0000033 GO_REF:0000107 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Gpx3 glutathione peroxidase 3 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:10617683)
GO_Central
RGD
PMID:10617683 GO_REF:0000033 NCBI chr10:39,529,335...39,537,406 JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:15,337,265...15,338,121 JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 involved_in ISO
IBA
(PMID:19740759)
GO_REF:0000033
RGD
GO_Central
PMID:19740759 GO_REF:0000033 NCBI chr10:15,828,291...15,829,138 JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 involved_in ISO (PMID:19740759) RGD PMID:19740759 NCBI chr10:15,311,637...15,312,481 JBrowse link
G Hbb hemoglobin subunit beta involved_in ISO
IBA
(PMID:19740759)
GO_REF:0000033
RGD
GO_Central
PMID:19740759 GO_REF:0000033 NCBI chr 1:167,662,310...167,663,721 JBrowse link
G Hbb-b2 hemoglobin, beta adult minor chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,243,696...158,245,076 JBrowse link
G Hbb-bs hemoglobin, beta adult s chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,218,356...158,219,741 JBrowse link
G Hbbl1 hemoglobin subunit beta like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,236,972...158,238,348 JBrowse link
G Hbe1 hemoglobin subunit epsilon 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,282,931...158,458,855 JBrowse link
G Hbe1l-ps1 hemoglobin subunit epsilon 1 like, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,266,601...158,267,985 JBrowse link
G Hbe2 hemoglobin, epsilon 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,279,285...158,280,913 JBrowse link
G Hbg1 hemoglobin subunit gamma 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:158,271,871...158,273,426 JBrowse link
G Hbz hemoglobin subunit zeta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:15,848,279...15,849,757 JBrowse link
G Mpo myeloperoxidase involved_in
acts_upstream_of_or_within
ISO (PMID:10772654)
MGI:2176344 (PMID:10085024)
(PMID:11907569)
RGD PMID:10085024 PMID:10772654 PMID:11907569 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Prdx1 peroxiredoxin 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:18606987)
GO_REF:0000033
(PMID:11986303)
RGD
GO_Central
PMID:11986303 PMID:18606987 GO_REF:0000033 NCBI chr 5:135,383,906...135,399,504 JBrowse link
G Prdx1l1 peroxiredoxin 1-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:193,602,142...193,603,085 JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:2668456 (PMID:15902258)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:15902258 GO_REF:0000033 GO_REF:0000107 NCBI chr19:23,180,927...23,186,217 JBrowse link
G Prdx3 peroxiredoxin 3 involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
(PMID:18195003)
GO_REF:0000033
GO_REF:0000107
(PMID:7733872)
RGD
GO_Central
Ensembl
PMID:7733872 PMID:18195003 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:260,001,642...260,014,064 JBrowse link
G Prdx4 peroxiredoxin 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:43,876,374...43,893,815 JBrowse link
G Prdx5 peroxiredoxin 5 involved_in ISO
IBA
(PMID:10514471)
GO_REF:0000033
RGD
GO_Central
PMID:10514471 GO_REF:0000033 NCBI chr 1:204,099,826...204,103,589 JBrowse link
G Prdx6 peroxiredoxin 6 IDA RGD PMID:8641418 RGD:729495 NCBI chr13:73,528,746...73,539,295 JBrowse link
G Pxdn peroxidasin involved_in ISO (PMID:18929642) RGD PMID:18929642 NCBI chr 6:46,580,749...46,658,345 JBrowse link
G Tpo thyroid peroxidase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:52,425,998...52,495,793 JBrowse link
G Txnrd1 thioredoxin reductase 1 IMP RGD PMID:10849437 RGD:634378 NCBI chr 7:22,717,620...22,802,553 JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:58,300,069...58,315,725 JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:44,322,635...44,514,498 JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300 JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:38,287,355...38,298,234 JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:86,311,528...86,363,513 JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hp haptoglobin involved_in ISO (PMID:19740759) RGD PMID:19740759 NCBI chr19:54,449,151...54,453,701 JBrowse link
G Mt3 metallothionein 3 IDA RGD PMID:12058024 RGD:625483 NCBI chr19:10,848,754...10,850,158 JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:18606987) RGD PMID:18606987 NCBI chr  X:14,550,645...14,572,445 JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) RGD PMID:22814254 NCBI chr 3:109,249,815...109,260,511 JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268), (PMID:22814254) RGD PMID:16651268 PMID:22814254 NCBI chr 3:109,245,337...109,249,055 JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502 JBrowse link
G Nox4 NADPH oxidase 4 IMP RGD PMID:27279484 RGD:151347625 NCBI chr 1:150,313,736...150,491,480 JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:20529999 RGD:27095884 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,455...12,623,615 JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase IMP RGD PMID:24722990 RGD:13513981 NCBI chr 2:53,144,157...53,237,857 JBrowse link
G Snca synuclein alpha involved_in ISO
IEA
(PMID:23507046)
GO_REF:0000107
RGD
Ensembl
PMID:23507046 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444 JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor IDA in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chr12:5,991,135...6,129,275 JBrowse link
G Noxa1 NADPH oxidase activator 1 involved_in ISO (PMID:16636067) RGD PMID:16636067 NCBI chr 3:28,293,643...28,309,828 JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:24553947) RGD PMID:24553947 NCBI chr 5:155,813,838...155,825,950 JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2668456 (PMID:17325201)
Ensembl
RGD
PMID:17325201 GO_REF:0000107 NCBI chr19:23,180,927...23,186,217 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      metabolic process 12157
        reactive oxygen species metabolic process 275
          hydrogen peroxide metabolic process 65
            detoxification of hydrogen peroxide + 3
            hydrogen peroxide biosynthetic process + 21
            hydrogen peroxide catabolic process + 37
            negative regulation of hydrogen peroxide metabolic process + 9
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 21
paths to the root