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ONTOLOGY REPORT - ANNOTATIONS

Term:hydrogen peroxide biosynthetic process
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Accession:GO:0050665 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 biosynthetic process;   hydrogen peroxide anabolism;   hydrogen peroxide biosynthesis;   hydrogen peroxide formation;   hydrogen peroxide generation;   hydrogen peroxide synthesis


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hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:32169171)		 UniProt
Ensembl
RGD		 PMID:32169171 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Cyba cytochrome b-245 alpha chain involved_in IMP PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain acts_upstream_of_or_within ISO MGI:1857284 (MGI:3050718|PMID:15258578) RGD PMID:15258578 MGI:3050718 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 acts_upstream_of_or_within ISO MGI:2182307 (MGI:3037497|PMID:14980704) RGD PMID:14980704 MGI:3037497 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 acts_upstream_of_or_within ISO MGI:2182351 (MGI:3037497|PMID:14980704) RGD PMID:14980704 MGI:3037497 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Duox1 dual oxidase 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q1HG43 (PMID:19339556), (PMID:22814254)		 Ensembl
RGD		 PMID:19339556 PMID:22814254 GO_REF:0000107 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 involved_in ISO UniProtKB:Q1HG44 (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) RGD PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (MGI:3050718|PMID:15258578) RGD PMID:15258578 MGI:3050718 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in		 IMP
IDA
ISO
ISS		 MGI:1857873 (MGI:2682495|PMID:14679182)
GO_REF:0000024
(PMID:15544046)		 RGD
UniProt		 PMID:14679182 PMID:15544046 PMID:15880490 PMID:12514262 PMID:10640619 GO_REF:0000024 MGI:2682495, RGD:1581090, RGD:634854, RGD:1601266 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 IDA RGD PMID:15642720 RGD:2291946 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649 		JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) RGD PMID:22814254 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268), (PMID:22814254) RGD PMID:16651268 PMID:22814254 NCBI chr 3:109,245,476...109,248,844
Ensembl chr 3:109,245,476...109,248,968 		JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IMP RGD PMID:19306371 RGD:13506652 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Nox4 NADPH oxidase 4 IMP RGD PMID:27279484 RGD:151347625 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:20529999 RGD:27095884 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,470...12,623,615
Ensembl chr10:12,615,190...12,623,615 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      organic substance metabolic process 11597
        hydrogen peroxide metabolic process 62
          hydrogen peroxide biosynthetic process 22
            negative regulation of hydrogen peroxide biosynthetic process 6
            positive regulation of hydrogen peroxide biosynthetic process 7
            regulation of hydrogen peroxide biosynthetic process + 13
Path 2
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      cellular metabolic process 9531
        reactive oxygen species metabolic process 263
          reactive oxygen species biosynthetic process 73
            hydrogen peroxide biosynthetic process 22
              negative regulation of hydrogen peroxide biosynthetic process 6
              positive regulation of hydrogen peroxide biosynthetic process 7
              regulation of hydrogen peroxide biosynthetic process + 13
paths to the root