Gene: Nnt (nicotinamide nucleotide transhydrogenase) Rattus norvegicus
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Symbol: Nnt
Name: nicotinamide nucleotide transhydrogenase
Description: ENCODES a protein that exhibits NADP binding (ortholog); INVOLVED IN cell redox homeostasis; cellular oxidant detoxification; NADPH regeneration; PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide metabolic pathway; monoterpenoid biosynthetic pathway; ASSOCIATED WITH obesity; Glucocorticoid Deficiency 4 (ortholog); FOUND IN mitochondrion; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2,2-tetramine
AGR Description: Predicted to have NAD binding activity, NAD(P)+ transhydrogenase activity, and NADP binding activity; involved in several processes, including NADPH regeneration, cell redox homeostasis, and cellular oxidant detoxification; localizes to the mitochondrion; biomarker of obesity; orthologous to human NNT (nicotinamide nucleotide transhydrogenase).
Merged Description: Predicted to have NAD binding activity, NAD(P)+ transhydrogenase activity, and NADP binding activity; involved in several processes, including NADPH regeneration, cell redox homeostasis, and cellular oxidant detoxification; localizes to the mitochondrion; biomarker of obesity; orthologous to human NNT (nicotinamide nucleotide transhydrogenase); PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide metabolic pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC109126; NAD(P) transhydrogenase, mitochondrial; nicotinamide nucleotide transhydrogenase (mapped); Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase); Nnt_mapped
Orthologs:
Homo sapiens (human) : NNT (nicotinamide nucleotide transhydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Nnt (nicotinamide nucleotide transhydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nnt (nicotinamide nucleotide transhydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : NNT (nicotinamide nucleotide transhydrogenase)
Canis lupus familiaris (dog) : NNT (nicotinamide nucleotide transhydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nnt (nicotinamide nucleotide transhydrogenase)
Sus scrofa (pig) : NNT (nicotinamide nucleotide transhydrogenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0252,189,523 - 52,283,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0270,553,338 - 70,644,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4251,496,456 - 51,589,901 (-)NCBIRGSC3.4rn4RGSC3.4
Celera247,067,409 - 47,159,610 (-)NCBICelera
Cytogenetic Map2q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nnt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1587346
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.