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ONTOLOGY REPORT - ANNOTATIONS


Term:T cell mediated cytotoxicity
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Accession:GO:0001913 term browser browse the term
Definition:The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
Synonyms:exact_synonym: T cell mediated apoptosis;   T cell mediated cell death;   T cell mediated cell killing;   T-lymphocyte mediated cytotoxicity
 related_synonym: T cell mediated cytolysis



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T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin acts_upstream_of ISO (MGI:3611636|PMID:16299293) RGD PMID:16299293 MGI:3611636 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Cadm1 cell adhesion molecule 1 NOT|involved_in ISO (PMID:15811952) RGD PMID:15811952 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
JBrowse link
G Crtam cytotoxic and regulatory T cell molecule NOT|involved_in ISO (PMID:15811952) RGD PMID:15811952 NCBI chr 8:41,340,117...41,377,343
Ensembl chr 8:41,340,837...41,377,343
JBrowse link
G Ctsc cathepsin C involved_in ISO UniProtKB:P49935 (MGI:4838939|PMID:20435891) RGD PMID:20435891 MGI:4838939 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctsh cathepsin H involved_in ISS
ISO
GO_REF:0000024
UniProtKB:P97821 (MGI:4838939|PMID:20435891)
UniProt
RGD
PMID:20435891 GO_REF:0000024 MGI:4838939 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824
JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 acts_upstream_of_or_within ISO MGI:4359722 (MGI:7294920|PMID:35482418) RGD PMID:35482418 MGI:7294920 NCBI chr 7:75,810,950...75,828,902
Ensembl chr 7:75,810,594...75,861,248
JBrowse link
G Emp2 epithelial membrane protein 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5605955|PMID:12763482)
UniProt
RGD
PMID:12763482 GO_REF:0000024 MGI:5605955 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
JBrowse link
G Gfus GDP-L-fucose synthase acts_upstream_of_or_within ISO (MGI:58355|PMID:2568889) RGD PMID:2568889 MGI:58355 NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948
JBrowse link
G Gzmb granzyme B acts_upstream_of_or_within ISO MGI:1857156 (MGI:3665503|PMID:16618603) RGD PMID:16618603 MGI:3665503 NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G Gzmm granzyme M involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3531039|PMID:15454490)
Ensembl
RGD
PMID:15454490 GO_REF:0000107 MGI:3531039 NCBI chr 7:10,011,065...10,016,841
Ensembl chr 7:10,011,066...10,016,665
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within ISO MGI:1857299 (MGI:2675193|PMID:12944494) RGD PMID:12944494 MGI:2675193 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of ISO MGI:1857198 (MGI:893318|PMID:9215624) RGD PMID:9215624 MGI:893318 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in ISO (PMID:10426993) RGD PMID:10426993 NCBI chr 1:78,372,138...78,398,932
Ensembl chr 1:78,372,802...78,398,930
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of ISO MGI:3042190 (MGI:3040567|PMID:14761980) RGD PMID:14761980 MGI:3040567 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta acts_upstream_of ISO MGI:2181294 (MGI:3772519|PMID:18097009) RGD PMID:18097009 MGI:3772519 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Prf1 perforin 1 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3531039|PMID:15454490)
(MGI:5285144|PMID:21037563), (MGI:6830380|PMID:26306037)
PMID:21873635
RGD PMID:15454490 PMID:21037563 PMID:26306037 PMID:21873635 MGI:3531039 MGI:5285144 MGI:6830380, RGD:13792537 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
G Raet1e retinoic acid early transcript 1E acts_upstream_of_or_within ISO (MGI:3037535|PMID:11567106) RGD PMID:11567106 MGI:3037535 NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 acts_upstream_of ISO (MGI:50291|PMID:1538753) RGD PMID:1538753 MGI:50291 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 acts_upstream_of ISO (MGI:50291|PMID:1538753) RGD PMID:1538753 MGI:50291 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Serpinb9 serpin family B member 9 acts_upstream_of_or_within ISO MGI:3687210 (MGI:3665503|PMID:16618603) RGD PMID:16618603 MGI:3665503 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (MGI:5460953|PMID:23042080) RGD PMID:23042080 MGI:5460953 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member acts_upstream_of
involved_in
ISO
IEA
(MGI:3611636|PMID:16299293), (MGI:50291|PMID:1538753)
GO_REF:0000107
RGD
Ensembl
PMID:1538753 PMID:16299293 GO_REF:0000107 MGI:3611636 MGI:50291 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO MGI:1856656 (MGI:3653524|PMID:11266473) RGD PMID:11266473 MGI:3653524 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (MGI:5460953|PMID:23042080), (MGI:5471188|PMID:23190531) RGD PMID:23042080 PMID:23190531 MGI:5460953 MGI:5471188 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164
JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (PMID:32647003) RGD PMID:32647003 NCBI chr 7:134,577,443...134,622,934
Ensembl chr 7:134,577,482...134,622,934
JBrowse link
negative regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of_or_within ISO MGI:1857198 (MGI:893318|PMID:9215624) RGD PMID:9215624 MGI:893318 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Klrc1 killer cell lectin like receptor C1 involved_in ISO (PMID:9485206) RGD PMID:9485206 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
JBrowse link
G Klrd1 killer cell lectin like receptor D1 involved_in ISO
ISS
(PMID:9485206)
GO_REF:0000024
RGD
UniProt
PMID:9485206 GO_REF:0000024 NCBI chr 4:163,044,920...163,056,568
Ensembl chr 4:163,045,067...163,056,518
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta acts_upstream_of_or_within ISO MGI:2181294 (MGI:3772519|PMID:18097009) RGD PMID:18097009 MGI:3772519 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISS
ISO
GO_REF:0000024
(MGI:3654612|PMID:9725213)
UniProt
RGD
PMID:9725213 GO_REF:0000024 MGI:3654612 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:11290782) RGD PMID:11290782 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
negative regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Muc4 mucin 4, cell surface associated IDA RGD PMID:10232613 RGD:2303754 NCBI chr11:68,008,245...68,053,229 JBrowse link
positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin acts_upstream_of_or_within ISO (MGI:3611636|PMID:16299293) RGD PMID:16299293 MGI:3611636 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:2180705|PMID:10201995)
PMID:21873635
RGD PMID:10201995 PMID:21873635 MGI:2180705, RGD:13792537 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
JBrowse link
G Cyrib CYFIP related Rac1 interactor B involved_in ISO (MGI:5432330|PMID:22522492) RGD PMID:22522492 MGI:5432330 NCBI chr 7:95,633,876...95,760,588
Ensembl chr 7:95,633,876...95,697,686
JBrowse link
G Fadd Fas associated via death domain involved_in ISS
ISO
GO_REF:0000024
(MGI:5291865|PMID:21876153)
UniProt
RGD
PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A IDA prevention of heat shock-induced resistance to CTL-mediated killing RGD PMID:10679071 RGD:1298959 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IMP RGD PMID:8871636 RGD:10059395 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:1674604), (PMID:2204066) RGD PMID:1674604 PMID:2204066 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B involved_in ISO (MGI:3027369|PMID:14688363) RGD PMID:14688363 MGI:3027369 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (MGI:3027369|PMID:14688363) RGD PMID:14688363 MGI:3027369 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like acts_upstream_of_or_within ISO MGI:3701255 (MGI:3611636|PMID:16299293), (MGI:3700863|PMID:16461341), (MGI:3700871|PMID:16476767), (MGI:52901|PMID:8464890) RGD PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767 MGI:3611636 MGI:3700863 MGI:3700871 MGI:52901
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:3042190 (MGI:3040567|PMID:14761980) RGD PMID:14761980 MGI:3040567 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO (MGI:55923|PMID:6233370) RGD PMID:6233370 MGI:55923 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 involved_in IDA
ISO
(PMID:2420472) RGD PMID:2420472 PMID:11773898 RGD:2313503 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 acts_upstream_of_or_within
involved_in
ISO (MGI:50291|PMID:1538753)
(PMID:25631937)
RGD PMID:1538753 PMID:25631937 MGI:50291 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:23851683) RGD PMID:23851683 NCBI chr20:3,403,418...3,479,476 JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:29884618) RGD PMID:29884618 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:29884618) RGD PMID:29884618 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 acts_upstream_of_or_within ISO MGI:3701255 (MGI:3611636|PMID:16299293), (MGI:3700863|PMID:16461341), (MGI:3700871|PMID:16476767), (MGI:52901|PMID:8464890) RGD PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767 MGI:3611636 MGI:3700863 MGI:3700871 MGI:52901 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in
acts_upstream_of_or_within
ISO (PMID:25631937)
(MGI:50291|PMID:1538753)
RGD PMID:1538753 PMID:25631937 MGI:50291 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Stx7 syntaxin 7 involved_in ISO
IEA
(PMID:21438968)
GO_REF:0000107
RGD
Ensembl
PMID:21438968 GO_REF:0000107 NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member acts_upstream_of_or_within
involved_in
ISO
IEA
IDA
(MGI:3611636|PMID:16299293), (MGI:50291|PMID:1538753)
GO_REF:0000107
PMID:1758495
RGD
Ensembl
PMID:1538753 PMID:16299293 PMID:1758495 GO_REF:0000107 MGI:3611636 MGI:50291, RGD:1299069 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:18832695) RGD PMID:18832695 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related involved_in ISO
IEA
(PMID:31959982)
GO_REF:0000107
RGD
Ensembl
PMID:31959982 GO_REF:0000107 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Slc22a13l1 solute carrier family 22 member 13-like 1 involved_in ISO (PMID:19282870) RGD PMID:19282870 NCBI chr 8:118,958,209...118,972,614
Ensembl chr 8:118,961,000...118,966,046
JBrowse link
regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO (PMID:22473704) RGD PMID:22473704 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO
GO_REF:0000024
UniProtKB:Q61160 (MGI:5291865|PMID:21876153)
UniProt
RGD
PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nectin2 nectin cell adhesion molecule 2 involved_in IBA
ISO
PMID:21873635
(PMID:15039383)
RGD PMID:15039383 PMID:21873635 RGD:13792537 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:15039383) RGD PMID:15039383 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19898
    cellular process 18295
      cell killing 228
        leukocyte mediated cytotoxicity 140
          T cell mediated cytotoxicity 51
            T cell mediated cytotoxicity directed against tumor cell target + 3
            cytotoxic T cell degranulation + 4
            negative regulation of T cell mediated cytotoxicity + 9
            positive regulation of T cell mediated cytotoxicity + 26
            regulation of T cell mediated cytotoxicity + 35
Path 2
Term Annotations click to browse term
  biological_process 19898
    immune system process 2579
      immune effector process 687
        leukocyte mediated immunity 448
          lymphocyte mediated immunity 335
            T cell mediated immunity 121
              T cell mediated cytotoxicity 51
                T cell mediated cytotoxicity directed against tumor cell target + 3
                cytotoxic T cell degranulation + 4
                negative regulation of T cell mediated cytotoxicity + 9
                positive regulation of T cell mediated cytotoxicity + 26
                regulation of T cell mediated cytotoxicity + 35
paths to the root