ONTOLOGY REPORT - ANNOTATIONS
Term: T cell mediated cytotoxicity
Accession: GO:0001913
browse the term
Definition: The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
Synonyms: exact_synonym: T cell mediated apoptosis; T cell mediated cell death; T cell mediated cell killing; T-lymphocyte mediated cytotoxicity
related_synonym: T cell mediated cytolysis
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B2m
beta-2 microglobulin
acts_upstream_of
ISO
(PMID:16299293)
RGD
PMID:16299293
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Cadm1
cell adhesion molecule 1
NOT|involved_in
ISO
(PMID:15811952)
RGD
PMID:15811952
NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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Crtam
cytotoxic and regulatory T cell molecule
NOT|involved_in
ISO
(PMID:15811952)
RGD
PMID:15811952
NCBI chr 8:41,340,117...41,377,381
Ensembl chr 8:41,340,837...41,377,343
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Ctsc
cathepsin C
involved_in
ISO
UniProtKB:P49935 (MGI:4838939|PMID:20435891)
RGD
PMID:20435891
MGI:4838939
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Ctsh
cathepsin H
involved_in
ISS ISO
GO_REF:0000024 UniProtKB:P97821 (MGI:4838939|PMID:20435891)
UniProt RGD
PMID:20435891
GO_REF:0000024 MGI:4838939
NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824
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Ebag9
estrogen receptor binding site associated antigen 9
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:4359722 (PMID:35482418)
Ensembl RGD
PMID:35482418
GO_REF:0000107
NCBI chr 7:75,810,950...75,828,902
Ensembl chr 7:75,810,594...75,861,248
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Emp2
epithelial membrane protein 2
involved_in
ISS ISO
GO_REF:0000024 (MGI:5605955|PMID:12763482)
UniProt RGD
PMID:12763482
GO_REF:0000024 MGI:5605955
NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
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Gfus
GDP-L-fucose synthase
acts_upstream_of_or_within
ISO
(PMID:2568889)
RGD
PMID:2568889
NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948
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Gzmb
granzyme B
acts_upstream_of_or_within
ISO
MGI:1857156 (PMID:16618603)
RGD
PMID:16618603
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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Gzmm
granzyme M
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 (PMID:15454490)
Ensembl RGD
PMID:15454490
GO_REF:0000107
NCBI chr 7:10,011,065...10,016,841
Ensembl chr 7:10,011,066...10,016,665
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Hprt1
hypoxanthine phosphoribosyltransferase 1
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:1857299 (PMID:12944494)
Ensembl RGD
PMID:12944494
GO_REF:0000107
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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Il7r
interleukin 7 receptor
acts_upstream_of
ISO
MGI:1857198 (PMID:9215624)
RGD
PMID:9215624
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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Mill1
MHC I like leukocyte 1
involved_in
ISO
(PMID:10426993)
RGD
PMID:10426993
NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930
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P2rx7
purinergic receptor P2X 7
acts_upstream_of
ISO
MGI:3042190 (PMID:14761980)
RGD
PMID:14761980
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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Ppp3cb
protein phosphatase 3 catalytic subunit beta
involved_in acts_upstream_of
IEA ISO
GO_REF:0000107 MGI:2181294 (PMID:18097009)
Ensembl RGD
PMID:18097009
GO_REF:0000107
NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
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Prf1
perforin 1
involved_in acts_upstream_of_or_within
IEA ISO IBA
GO_REF:0000107 (MGI:69649|PMID:7972104), (PMID:21037563), (PMID:26306037) (PMID:15454490) GO_REF:0000033
Ensembl RGD GO_Central
PMID:7972104 PMID:15454490 PMID:21037563 PMID:26306037
GO_REF:0000033 GO_REF:0000107 MGI:69649
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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Raet1e
retinoic acid early transcript 1E
acts_upstream_of_or_within
ISO
(PMID:11567106)
RGD
PMID:11567106
NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755
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RT1-A2
RT1 class Ia, locus A2
acts_upstream_of
ISO
(PMID:1538753)
RGD
PMID:1538753
NCBI chr20:4,870,939...4,910,183
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RT1-CE16
RT1 class I, locus CE16
involved_in
ISO
(PMID:7504010)
RGD
PMID:7504010
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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Serpinb9
serpin family B member 9
acts_upstream_of_or_within
ISO
MGI:3687210 (PMID:16618603)
RGD
PMID:16618603
NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
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Stx11
syntaxin 11
acts_upstream_of_or_within
ISO
MGI:5461477 (PMID:23042080)
RGD
PMID:23042080
NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164
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Tap2
transporter 2, ATP binding cassette subfamily B member
involved_in acts_upstream_of
IEA ISO
GO_REF:0000107 (PMID:1538753), (PMID:16299293)
Ensembl RGD
PMID:1538753 PMID:16299293
GO_REF:0000107
NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
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Rab27a
RAB27A, member RAS oncogene family
acts_upstream_of_or_within
ISO
MGI:1856656 (PMID:11266473)
RGD
PMID:11266473
NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
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Stx11
syntaxin 11
acts_upstream_of_or_within
ISO
MGI:5461477 (PMID:23042080), (PMID:23190531)
RGD
PMID:23042080 PMID:23190531
NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164
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Ceacam1
CEA cell adhesion molecule 1
involved_in
ISO ISS
(PMID:18424730) GO_REF:0000024
RGD UniProt
PMID:18424730
GO_REF:0000024
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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Nckap1l
NCK associated protein 1 like
involved_in
ISO
(PMID:32647003)
RGD
PMID:32647003
NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934
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Ceacam1
CEA cell adhesion molecule 1
involved_in
ISO ISS
(PMID:18424730) GO_REF:0000024
RGD UniProt
PMID:18424730
GO_REF:0000024
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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Il7r
interleukin 7 receptor
acts_upstream_of_or_within
ISO
MGI:1857198 (PMID:9215624)
RGD
PMID:9215624
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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Klrc1
killer cell lectin like receptor C1
involved_in
ISO
(PMID:9485206)
RGD
PMID:9485206
NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
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Klrd1
killer cell lectin like receptor D1
involved_in
ISO IEA ISS
(PMID:9485206) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:9485206
GO_REF:0000024 GO_REF:0000107
NCBI chr 4:163,044,920...163,056,568
Ensembl chr 4:163,045,067...163,056,518
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Ppp3cb
protein phosphatase 3 catalytic subunit beta
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2181294 (PMID:18097009)
Ensembl RGD
PMID:18097009
GO_REF:0000107
NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
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Ptprc
protein tyrosine phosphatase, receptor type, C
involved_in
ISS ISO
GO_REF:0000024 (MGI:3654612|PMID:9725213)
UniProt RGD
PMID:9725213
GO_REF:0000024 MGI:3654612
NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
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RT1-M3-1
RT1 class Ib, locus M3, gene 1
involved_in
ISO
(PMID:11290782)
RGD
PMID:11290782
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
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Muc4
mucin 4, cell surface associated
IDA
RGD
PMID:10232613
RGD:2303754
NCBI chr11:68,008,245...68,053,242
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AABR07000137.1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
Ensembl chr 1:1,307,185...1,308,310
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AABR07000147.1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
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AABR07001348.1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
Ensembl chr 1:39,668,472...39,670,153
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B2m
beta-2 microglobulin
acts_upstream_of_or_within
ISO
(PMID:16299293)
RGD
PMID:16299293
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Cd1d1
CD1d1 molecule
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 (PMID:10201995)
GO_Central RGD
PMID:10201995
GO_REF:0000033
NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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Cyrib
CYFIP related Rac1 interactor B
involved_in
ISO
(MGI:5432330|PMID:22522492)
RGD
PMID:22522492
MGI:5432330
NCBI chr 7:95,633,876...95,760,588
Ensembl chr 7:95,633,876...95,697,686
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Fadd
Fas associated via death domain
involved_in
ISS ISO
GO_REF:0000024 (MGI:5291865|PMID:21876153)
UniProt RGD
PMID:21876153
GO_REF:0000024 MGI:5291865
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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H60al
histocompatibility 60a like
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:1,382,896...1,386,846
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Hfe
homeostatic iron regulator
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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Hspa1b
heat shock protein family A (Hsp70) member 1B
IDA
prevention of heat shock-induced resistance to CTL-mediated killing
RGD
PMID:10679071
RGD:1298959
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Hspa8
heat shock protein family A (Hsp70) member 8
IMP
RGD
PMID:8871636
RGD:10059395
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Il12a
interleukin 12A
involved_in
ISO IEA
(PMID:1674604), (PMID:2204066) GO_REF:0000107
RGD Ensembl
PMID:1674604 PMID:2204066
GO_REF:0000107
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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Il12b
interleukin 12B
involved_in
ISO
(MGI:3027369|PMID:14688363)
RGD
PMID:14688363
MGI:3027369
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il23a
interleukin 23 subunit alpha
involved_in
ISO
(MGI:3027369|PMID:14688363)
RGD
PMID:14688363
MGI:3027369
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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Micb
MHC class I polypeptide-related sequence B
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827
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Mill1
MHC I like leukocyte 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930
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P2rx7
purinergic receptor P2X 7
acts_upstream_of_or_within
ISO
MGI:3042190 (PMID:14761980)
RGD
PMID:14761980
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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Ptprc
protein tyrosine phosphatase, receptor type, C
acts_upstream_of_or_within
ISO
(PMID:6233370)
RGD
PMID:6233370
NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
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Raet1l
retinoic acid early transcript 1L
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:1,979,433...1,984,410
Ensembl chr 1:1,979,443...1,984,410
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RT1-A
RT1 class I, locus A
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
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RT1-A1
RT1 class Ia, locus A1
IDA
RGD
PMID:11773898
RGD:2313503
NCBI chr20:4,905,309...4,914,593
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RT1-A2
RT1 class Ia, locus A2
involved_in acts_upstream_of_or_within
ISO
(PMID:20195504), (PMID:25631937) (PMID:1538753)
RGD
PMID:1538753 PMID:20195504 PMID:25631937
NCBI chr20:4,870,939...4,910,183
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RT1-CE1
RT1 class I, locus1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:3,555,779...3,559,487
Ensembl chr20:3,555,782...3,559,486
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RT1-CE10
RT1 class I, locus CE10
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:3,377,284...3,380,301
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RT1-CE11
RT1 class I, locus CE11
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:3,355,393...3,358,520
Ensembl chr20:3,350,937...3,380,362
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RT1-CE12
RT1 class I, locus CE12
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:3,338,907...3,342,547
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RT1-CE16
RT1 class I, locus CE16
involved_in
ISO
(PMID:22031944), (PMID:2420472), (PMID:25631937), (PMID:8805302)
RGD
PMID:2420472 PMID:8805302 PMID:22031944 PMID:25631937
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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RT1-CE3
RT1 class I, locus CE3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:3,516,647...3,520,938
Ensembl chr20:2,623,953...2,692,081
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RT1-CE5
RT1 class I, locus CE5
involved_in
ISO
(PMID:23851683)
RGD
PMID:23851683
NCBI chr20:3,403,418...3,479,476
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RT1-Da
RT1 class II, locus Da
involved_in
ISO
(PMID:29884618)
RGD
PMID:29884618
NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
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RT1-Db1
RT1 class II, locus Db1
involved_in
ISO
(PMID:29884618)
RGD
PMID:29884618
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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RT1-M2
RT1 class Ib, locus M2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:978,918...981,510
Ensembl chr20:978,935...981,723
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RT1-M3-1
RT1 class Ib, locus M3, gene 1
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:3701255 (PMID:16299293), (PMID:16461341), (PMID:16476767), (PMID:8464890)
GO_Central RGD
PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767
GO_REF:0000033
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
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RT1-M5
RT1 class Ib, locus M5
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:1,546,496...1,548,948
Ensembl chr20:1,546,511...1,548,775
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RT1-M6-2
RT1 class I, locus M6, gene 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:1,583,267...1,587,099
Ensembl chr20:1,583,299...1,586,215
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RT1-N1
RT1 class Ib, locus N1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
G
RT1-N2
RT1 class Ib, locus N2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:2,641,157...2,645,439
Ensembl chr20:2,641,202...2,644,900
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RT1-N3
RT1 class Ib, locus N3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:2,659,132...2,665,536
Ensembl chr20:2,661,584...2,665,530
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RT1-O1l1
RT1 class Ib, locus O1 like 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:2,624,073...2,658,023
Ensembl chr20:2,623,953...2,692,081
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RT1-S3
RT1 class Ib, locus S3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
G
RT1-T24-1
RT1 class I, locus T24, gene 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:2,761,495...2,774,871
Ensembl chr20:2,718,279...2,776,154
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RT1-T24-3
RT1 class I, locus T24, gene 3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:2,718,210...2,730,604
Ensembl chr20:2,718,279...2,776,154
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RT1-T24-4
RT1 class I, locus T24, gene 4
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:2,684,515...2,747,878
Ensembl chr20:2,684,515...2,692,511
G
Stx7
syntaxin 7
involved_in
ISO IEA
(PMID:21438968) GO_REF:0000107
RGD Ensembl
PMID:21438968
GO_REF:0000107
NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279
G
Tap2
transporter 2, ATP binding cassette subfamily B member
acts_upstream_of_or_within involved_in
IDA ISO IEA
PMID:1758495 (PMID:1538753), (PMID:16299293) GO_REF:0000107
RGD Ensembl
PMID:1538753 PMID:16299293 PMID:1758495
GO_REF:0000107, RGD:1299069
NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
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Xcl1
X-C motif chemokine ligand 1
involved_in
ISO
(PMID:18832695)
RGD
PMID:18832695
NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329
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Mr1
major histocompatibility complex, class I-related
involved_in
ISO IEA
(PMID:31959982) GO_REF:0000107
RGD Ensembl
PMID:31959982
GO_REF:0000107
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
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Slc22a13
solute carrier family 22 member 13
involved_in
ISO
(PMID:19282870)
RGD
PMID:19282870
NCBI chr 8:118,922,367...118,934,020
Ensembl chr 8:118,922,367...118,953,635
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Ager
advanced glycosylation end product-specific receptor
involved_in
ISO IEA
(PMID:22473704) GO_REF:0000107
RGD Ensembl
PMID:22473704
GO_REF:0000107
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Ripk3
receptor-interacting serine-threonine kinase 3
involved_in
ISS ISO
GO_REF:0000024 UniProtKB:Q61160 (MGI:5291865|PMID:21876153)
UniProt RGD
PMID:21876153
GO_REF:0000024 MGI:5291865
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
G
Nectin2
nectin cell adhesion molecule 2
involved_in
ISO
(PMID:15039383)
RGD
PMID:15039383
NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
G
Pvr
PVR cell adhesion molecule
involved_in
ISO
(PMID:15039383)
RGD
PMID:15039383
NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
G
RT1-CE16
RT1 class I, locus CE16
involved_in
ISO
(PMID:1402688), (PMID:17189421), (PMID:20364150)
RGD
PMID:1402688 PMID:17189421 PMID:20364150
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all