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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell mediated cytotoxicity directed against tumor cell target
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Accession:GO:0002419 term browser browse the term
Definition:The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: T lymphocyte mediated cytotoxicity directed against tumor cell target


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T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-CE16 RT1 class I, locus CE16 involved_in ISO (PMID:1402688), (PMID:17189421), (PMID:20364150) RGD PMID:1402688 PMID:17189421 PMID:20364150 NCBI chr20:3,261,656...3,265,548 JBrowse link
negative regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Muc4 mucin 4, cell surface associated IDA RGD PMID:10232613 RGD:2303754 NCBI chr11:81,513,321...81,575,200 JBrowse link
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related involved_in ISO
IEA 		(PMID:31959982)
GO_REF:0000107 		RGD
Ensembl		 PMID:31959982 GO_REF:0000107 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502 		JBrowse link
G Slc22a13 solute carrier family 22 member 13 involved_in ISO (PMID:19282870) RGD PMID:19282870 NCBI chr 8:127,800,097...127,811,750
Ensembl chr 8:127,800,097...127,811,724 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2920
      immune response 2015
        immune response to tumor cell 41
          T cell mediated immune response to tumor cell 19
            T cell mediated cytotoxicity directed against tumor cell target 4
              negative regulation of T cell mediated cytotoxicity directed against tumor cell target 1
              positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
              regulation of T cell mediated cytotoxicity directed against tumor cell target + 3
Path 2
Term Annotations click to browse term
  biological_process 19315
    immune system process 2920
      immune effector process 750
        leukocyte mediated immunity 493
          lymphocyte mediated immunity 380
            T cell mediated immunity 156
              T cell mediated immune response to tumor cell 19
                T cell mediated cytotoxicity directed against tumor cell target 4
                  negative regulation of T cell mediated cytotoxicity directed against tumor cell target 1
                  positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
                  regulation of T cell mediated cytotoxicity directed against tumor cell target + 3
paths to the root