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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of T cell mediated cytotoxicity
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Accession:GO:0001916 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
Synonyms:exact_synonym: positive regulation of T cell mediated apoptosis;   positive regulation of T-cell mediated cell death;   positive regulation of T-cell mediated cell killing;   positive regulation of T-lymphocyte mediated cytotoxicity;   up regulation of T cell mediated cytotoxicity;   upregulation of T cell mediated cytotoxicity
 narrow_synonym: activation of T cell mediated cytotoxicity;   stimulation of T cell mediated cytotoxicity
 related_synonym: positive regulation of T-cell mediated cytolysis



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positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin acts_upstream_of_or_within ISO (MGI:3611636|PMID:16299293) RGD PMID:16299293 MGI:3611636 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:2180705|PMID:10201995)
PMID:21873635
RGD PMID:10201995 PMID:21873635 MGI:2180705, RGD:13792537 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
JBrowse link
G Cyrib CYFIP related Rac1 interactor B involved_in ISO (MGI:5432330|PMID:22522492) RGD PMID:22522492 MGI:5432330 NCBI chr 7:95,633,876...95,760,588
Ensembl chr 7:95,633,876...95,697,686
JBrowse link
G Fadd Fas associated via death domain involved_in ISS
ISO
GO_REF:0000024
(MGI:5291865|PMID:21876153)
UniProt
RGD
PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A IDA prevention of heat shock-induced resistance to CTL-mediated killing RGD PMID:10679071 RGD:1298959 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IMP RGD PMID:8871636 RGD:10059395 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:1674604), (PMID:2204066) RGD PMID:1674604 PMID:2204066 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B involved_in ISO (MGI:3027369|PMID:14688363) RGD PMID:14688363 MGI:3027369 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (MGI:3027369|PMID:14688363) RGD PMID:14688363 MGI:3027369 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like acts_upstream_of_or_within ISO MGI:3701255 (MGI:3611636|PMID:16299293), (MGI:3700863|PMID:16461341), (MGI:3700871|PMID:16476767), (MGI:52901|PMID:8464890) RGD PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767 MGI:3611636 MGI:3700863 MGI:3700871 MGI:52901
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:3042190 (MGI:3040567|PMID:14761980) RGD PMID:14761980 MGI:3040567 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO (MGI:55923|PMID:6233370) RGD PMID:6233370 MGI:55923 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 involved_in IDA
ISO
(PMID:2420472) RGD PMID:2420472 PMID:11773898 RGD:2313503 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 acts_upstream_of_or_within
involved_in
ISO (MGI:50291|PMID:1538753)
(PMID:25631937)
RGD PMID:1538753 PMID:25631937 MGI:50291 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:23851683) RGD PMID:23851683 NCBI chr20:3,403,418...3,479,476 JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:29884618) RGD PMID:29884618 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:29884618) RGD PMID:29884618 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 acts_upstream_of_or_within ISO MGI:3701255 (MGI:3611636|PMID:16299293), (MGI:3700863|PMID:16461341), (MGI:3700871|PMID:16476767), (MGI:52901|PMID:8464890) RGD PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767 MGI:3611636 MGI:3700863 MGI:3700871 MGI:52901 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in
acts_upstream_of_or_within
ISO (PMID:25631937)
(MGI:50291|PMID:1538753)
RGD PMID:1538753 PMID:25631937 MGI:50291 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Stx7 syntaxin 7 involved_in ISO
IEA
(PMID:21438968)
GO_REF:0000107
RGD
Ensembl
PMID:21438968 GO_REF:0000107 NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member acts_upstream_of_or_within
involved_in
ISO
IEA
IDA
(MGI:3611636|PMID:16299293), (MGI:50291|PMID:1538753)
GO_REF:0000107
PMID:1758495
RGD
Ensembl
PMID:1538753 PMID:16299293 PMID:1758495 GO_REF:0000107 MGI:3611636 MGI:50291, RGD:1299069 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:18832695) RGD PMID:18832695 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related involved_in ISO
IEA
(PMID:31959982)
GO_REF:0000107
RGD
Ensembl
PMID:31959982 GO_REF:0000107 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Slc22a13l1 solute carrier family 22 member 13-like 1 involved_in ISO (PMID:19282870) RGD PMID:19282870 NCBI chr 8:118,958,209...118,972,614
Ensembl chr 8:118,961,000...118,966,046
JBrowse link
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nectin2 nectin cell adhesion molecule 2 involved_in IBA
ISO
PMID:21873635
(PMID:15039383)
RGD PMID:15039383 PMID:21873635 RGD:13792537 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:15039383) RGD PMID:15039383 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19876
    cellular process 18552
      cell killing 228
        leukocyte mediated cytotoxicity 140
          positive regulation of leukocyte mediated cytotoxicity 68
            positive regulation of T cell mediated cytotoxicity 26
              positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
              positive regulation of cytotoxic T cell degranulation 0
              susceptibility to T cell mediated cytotoxicity 2
Path 2
Term Annotations click to browse term
  biological_process 19876
    biological regulation 13525
      regulation of biological process 13078
        regulation of immune system process 1541
          regulation of immune effector process 427
            regulation of leukocyte mediated immunity 270
              regulation of lymphocyte mediated immunity 198
                regulation of T cell mediated immunity 85
                  regulation of T cell mediated cytotoxicity 35
                    positive regulation of T cell mediated cytotoxicity 26
                      positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
                      positive regulation of cytotoxic T cell degranulation 0
                      susceptibility to T cell mediated cytotoxicity 2
paths to the root