Gzmm (granzyme M) - Rat Genome Database

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Gene: Gzmm (granzyme M) Rattus norvegicus
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Symbol: Gzmm
Name: granzyme M
RGD ID: 620022
Description: Enables serine-type peptidase activity. Predicted to be involved in apoptotic process and protein maturation. Predicted to act upstream of or within T cell mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GZMM (granzyme M); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: granzyme M (lymphocyte met-ase 1); lymphoctye Met-ase 1; met-ase; natural killer cell granular protease; RNK-Met-1
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,661,683 - 10,667,448 (-)NCBIGRCr8
mRatBN7.2710,011,065 - 10,016,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,011,066 - 10,016,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,891,888 - 12,897,490 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,769,969 - 14,775,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,629,438 - 12,634,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,893,431 - 12,899,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,893,432 - 12,899,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,062,467 - 13,068,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,526,384 - 11,533,590 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,526,394 - 11,533,533 (-)NCBI
Celera78,184,440 - 8,190,013 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. Smyth MJ, etal., J Biol Chem 1992 Dec 5;267(34):24418-25.
Additional References at PubMed
PMID:8889548   PMID:15326124   PMID:15454490   PMID:19946888   PMID:21857942   PMID:22206666  


Genomics

Comparative Map Data
Gzmm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,661,683 - 10,667,448 (-)NCBIGRCr8
mRatBN7.2710,011,065 - 10,016,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,011,066 - 10,016,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,891,888 - 12,897,490 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,769,969 - 14,775,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,629,438 - 12,634,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,893,431 - 12,899,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,893,432 - 12,899,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,062,467 - 13,068,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,526,384 - 11,533,590 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,526,394 - 11,533,533 (-)NCBI
Celera78,184,440 - 8,190,013 (-)NCBICelera
Cytogenetic Map7q11NCBI
GZMM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819544,053 - 549,922 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19544,034 - 549,924 (+)EnsemblGRCh38hg38GRCh38
GRCh3719544,053 - 549,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619495,027 - 500,919 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419495,026 - 500,919NCBI
Celera19268,078 - 273,971 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19314,019 - 320,234 (+)NCBIHuRef
CHM1_119543,125 - 549,515 (+)NCBICHM1_1
T2T-CHM13v2.019497,822 - 503,990 (+)NCBIT2T-CHM13v2.0
Gzmm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,524,854 - 79,531,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,524,854 - 79,531,095 (+)EnsemblGRCm39 Ensembl
GRCm381079,689,020 - 79,695,261 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,689,020 - 79,695,261 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,151,765 - 79,158,005 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,092,149 - 79,098,389 (+)NCBIMGSCv36mm8
Celera1080,703,335 - 80,709,575 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
GZMM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,870,103 - 4,877,454 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,108,179 - 4,116,170 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019584,712 - 591,186 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119514,047 - 521,578 (+)NCBIpanpan1.1PanPan1.1panPan2
GZMM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,753,813 - 77,759,852 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,753,817 - 77,761,436 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GZMM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16273,754 - 285,106 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6273,798 - 284,965 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023668827282 - 4,292 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gzmm
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:46
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000011086
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
AI327276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2710,017,754 - 10,017,858 (+)MAPPERmRatBN7.2
Rnor_6.0712,900,124 - 12,900,227NCBIRnor6.0
Rnor_5.0713,069,160 - 13,069,263UniSTSRnor5.0
RGSC_v3.4711,534,710 - 11,534,813UniSTSRGSC3.4
Celera78,191,133 - 8,191,236UniSTS
Cytogenetic Map7q11UniSTS
RH143874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2710,011,852 - 10,012,148 (+)MAPPERmRatBN7.2
Rnor_6.0712,894,219 - 12,894,514NCBIRnor6.0
Rnor_5.0713,063,255 - 13,063,550UniSTSRnor5.0
RGSC_v3.4711,527,172 - 11,527,467UniSTSRGSC3.4
Celera78,185,228 - 8,185,523UniSTS
RH 3.4 Map791.7UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 217 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011086   ⟹   ENSRNOP00000011086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,011,066 - 10,016,665 (-)Ensembl
Rnor_6.0 Ensembl712,893,432 - 12,899,004 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095743   ⟹   ENSRNOP00000083530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,011,066 - 10,013,532 (-)Ensembl
RefSeq Acc Id: NM_057183   ⟹   NP_476531
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,256 (-)NCBI
mRatBN7.2710,011,065 - 10,016,638 (-)NCBI
Rnor_6.0712,893,431 - 12,899,004 (-)NCBI
Rnor_5.0713,062,467 - 13,068,040 (-)NCBI
RGSC_v3.4711,526,384 - 11,533,590 (-)RGD
Celera78,184,440 - 8,190,013 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078568   ⟹   XP_038934496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,441 (-)NCBI
mRatBN7.2710,011,065 - 10,016,841 (-)NCBI
RefSeq Acc Id: XM_039078569   ⟹   XP_038934497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,437 (-)NCBI
mRatBN7.2710,011,065 - 10,016,833 (-)NCBI
RefSeq Acc Id: XM_063263113   ⟹   XP_063119183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,448 (-)NCBI
RefSeq Acc Id: NP_476531   ⟸   NM_057183
- Peptide Label: precursor
- UniProtKB: Q03238 (UniProtKB/Swiss-Prot),   G3V726 (UniProtKB/TrEMBL),   A6K8Y7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011086   ⟸   ENSRNOT00000011086
RefSeq Acc Id: XP_038934496   ⟸   XM_039078568
- Peptide Label: isoform X2
- UniProtKB: Q03238 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038934497   ⟸   XM_039078569
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZVJ4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083530   ⟸   ENSRNOT00000095743
RefSeq Acc Id: XP_063119183   ⟸   XM_063263113
- Peptide Label: isoform X1
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03238-F1-model_v2 AlphaFold Q03238 1-258 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695056
Promoter ID:EPDNEW_R5580
Type:single initiation site
Name:Gzmm_1
Description:granzyme M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,898,979 - 12,899,039EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620022 AgrOrtholog
BioCyc Gene G2FUF-34882 BioCyc
Ensembl Genes ENSRNOG00000030530 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011086.7 UniProtKB/TrEMBL
  ENSRNOT00000095743.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29252 UniProtKB/TrEMBL
NCBI Gene 29252 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24271:SF51 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GZMM RGD
PhenoGen Gzmm PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030530 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVJ4 ENTREZGENE, UniProtKB/TrEMBL
  A6K8Y7 ENTREZGENE, UniProtKB/TrEMBL
  G3V726 ENTREZGENE, UniProtKB/TrEMBL
  GRAM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Gzmm  granzyme M  Gzmm  granzyme M (lymphocyte met-ase 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gzmm  granzyme M (lymphocyte met-ase 1)    lymphoctye Met-ase 1  Name updated 1299863 APPROVED
2002-08-07 Gzmm  lymphoctye Met-ase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 238 amino acids; hydrolytically cleaves peptide substrates after methionine, leucine, and norleucine 728406