GZMM (granzyme M) - Rat Genome Database

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Gene: GZMM (granzyme M) Homo sapiens
Analyze
Symbol: GZMM
Name: granzyme M
RGD ID: 1344003
HGNC Page HGNC:4712
Description: Enables serine-type endopeptidase activity. Involved in apoptotic process. Located in membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: granzyme M (lymphocyte met-ase 1); HU-Met-1; LMET1; lymphocyte met-ase 1; Met-1 serine protease; met-ase; MET1; natural killer cell granular protease
RGD Orthologs
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819544,053 - 549,922 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19544,034 - 549,924 (+)EnsemblGRCh38hg38GRCh38
GRCh3719544,053 - 549,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619495,027 - 500,919 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419495,026 - 500,919NCBI
Celera19268,078 - 273,971 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19314,019 - 320,234 (+)NCBIHuRef
CHM1_119543,125 - 549,515 (+)NCBICHM1_1
T2T-CHM13v2.019497,822 - 503,990 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7713495   PMID:8119738   PMID:8245461   PMID:8929545   PMID:12477932   PMID:12506019   PMID:15028722   PMID:15489334   PMID:15494398   PMID:16818775   PMID:18523284   PMID:19103589  
PMID:19542453   PMID:19896187   PMID:19946888   PMID:20107908   PMID:20406824   PMID:21059895   PMID:21857942   PMID:21909423   PMID:21979465   PMID:23099853   PMID:24316590   PMID:27133719  
PMID:27441655   PMID:32282833   PMID:32296183   PMID:33953729   PMID:34857952  


Genomics

Comparative Map Data
GZMM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819544,053 - 549,922 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19544,034 - 549,924 (+)EnsemblGRCh38hg38GRCh38
GRCh3719544,053 - 549,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619495,027 - 500,919 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419495,026 - 500,919NCBI
Celera19268,078 - 273,971 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19314,019 - 320,234 (+)NCBIHuRef
CHM1_119543,125 - 549,515 (+)NCBICHM1_1
T2T-CHM13v2.019497,822 - 503,990 (+)NCBIT2T-CHM13v2.0
Gzmm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,524,854 - 79,531,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,524,854 - 79,531,095 (+)EnsemblGRCm39 Ensembl
GRCm381079,689,020 - 79,695,261 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,689,020 - 79,695,261 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,151,765 - 79,158,005 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,092,149 - 79,098,389 (+)NCBIMGSCv36mm8
Celera1080,703,335 - 80,709,575 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gzmm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,661,683 - 10,667,448 (-)NCBIGRCr8
mRatBN7.2710,011,065 - 10,016,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,011,066 - 10,016,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,891,888 - 12,897,490 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,769,969 - 14,775,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,629,438 - 12,634,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,893,431 - 12,899,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,893,432 - 12,899,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,062,467 - 13,068,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,526,384 - 11,533,590 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,526,394 - 11,533,533 (-)NCBI
Celera78,184,440 - 8,190,013 (-)NCBICelera
Cytogenetic Map7q11NCBI
GZMM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,870,103 - 4,877,454 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,108,179 - 4,116,170 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019584,712 - 591,186 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119514,047 - 521,578 (+)NCBIpanpan1.1PanPan1.1panPan2
GZMM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,753,813 - 77,759,852 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,753,817 - 77,761,436 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GZMM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16273,754 - 285,106 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6273,798 - 284,965 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023668827282 - 4,292 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in GZMM
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.3(chr19:259395-819679)x3 copy number gain See cases [RCV000051144] Chr19:259395..819679 [GRCh38]
Chr19:259395..819679 [GRCh37]
Chr19:210395..770679 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:259395-2555149)x3 copy number gain See cases [RCV000051044] Chr19:259395..2555149 [GRCh38]
Chr19:259395..2555147 [GRCh37]
Chr19:210395..2506147 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:259395-1952650)x3 copy number gain See cases [RCV000052875] Chr19:259395..1952650 [GRCh38]
Chr19:259395..1952649 [GRCh37]
Chr19:210395..1903649 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|See cases [RCV000052876] Chr19:265917..8564134 [GRCh38]
Chr19:265917..8629018 [GRCh37]
Chr19:216917..8535018 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3(chr19:233565-4699472)x3 copy number gain See cases [RCV000052575] Chr19:233565..4699472 [GRCh38]
Chr19:233565..4699484 [GRCh37]
Chr19:184565..4650484 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:266117-1076399)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053911]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053911]|See cases [RCV000053911] Chr19:266117..1076399 [GRCh38]
Chr19:266117..1076398 [GRCh37]
Chr19:217117..1027398 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:259195-1351363)x1 copy number loss See cases [RCV000053910] Chr19:259195..1351363 [GRCh38]
Chr19:259195..1351362 [GRCh37]
Chr19:210195..1302362 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:421537-2897921)x3 copy number gain See cases [RCV000134894] Chr19:421537..2897921 [GRCh38]
Chr19:421537..2897919 [GRCh37]
Chr19:372537..2848919 [NCBI36]
Chr19:19p13.3		 likely pathogenic
GRCh38/hg38 19p13.3(chr19:259395-2068507)x3 copy number gain See cases [RCV000135433] Chr19:259395..2068507 [GRCh38]
Chr19:259395..2068506 [GRCh37]
Chr19:210395..2019506 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:275925-1892276)x3 copy number gain See cases [RCV000141358] Chr19:275925..1892276 [GRCh38]
Chr19:275925..1892275 [GRCh37]
Chr19:226925..1843275 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:259395-6795611)x3 copy number gain See cases [RCV000142627] Chr19:259395..6795611 [GRCh38]
Chr19:259395..6795622 [GRCh37]
Chr19:210395..6746622 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:260912-1163934)x3 copy number gain See cases [RCV000239425] Chr19:260912..1163934 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:277373-2555164)x3 copy number gain See cases [RCV000240507] Chr19:277373..2555164 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:548651-579366)x3 copy number gain See cases [RCV000446426] Chr19:548651..579366 [GRCh37]
Chr19:19p13.3		 benign
GRCh37/hg19 19p13.3(chr19:548651-571351)x3 copy number gain See cases [RCV000448384] Chr19:548651..571351 [GRCh37]
Chr19:19p13.3		 benign
GRCh37/hg19 19p13.3(chr19:260911-1965786)x3 copy number gain See cases [RCV000511452] Chr19:260911..1965786 [GRCh37]
Chr19:19p13.3		 likely pathogenic
GRCh37/hg19 19p13.3(chr19:415092-715725)x3 copy number gain See cases [RCV000511102] Chr19:415092..715725 [GRCh37]
Chr19:19p13.3		 likely benign
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
NM_005317.4(GZMM):c.607T>G (p.Cys203Gly) single nucleotide variant Inborn genetic diseases [RCV003286870] Chr19:549180 [GRCh38]
Chr19:549180 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:266117-1094614)x3 copy number gain not provided [RCV000513059] Chr19:266117..1094614 [GRCh37]
Chr19:19p13.3		 likely pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3(chr19:259395-3152419) copy number gain Global developmental delay [RCV000626520] Chr19:259395..3152419 [GRCh37]
Chr19:19p13.3		 likely pathogenic
GRCh37/hg19 19p13.3(chr19:260911-3200875)x3 copy number gain not provided [RCV000684094] Chr19:260911..3200875 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_005317.4(GZMM):c.253G>A (p.Asp85Asn) single nucleotide variant Inborn genetic diseases [RCV003268861] Chr19:548582 [GRCh38]
Chr19:548582 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:423160-1429367)x3 copy number gain not provided [RCV000752449] Chr19:423160..1429367 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:454430-617466)x3 copy number gain not provided [RCV000752450] Chr19:454430..617466 [GRCh37]
Chr19:19p13.3		 benign
GRCh37/hg19 19p13.3(chr19:483115-549496)x3 copy number gain not provided [RCV000752458] Chr19:483115..549496 [GRCh37]
Chr19:19p13.3		 benign
NM_005317.4(GZMM):c.504C>T (p.Leu168=) single nucleotide variant not provided [RCV000971077] Chr19:549077 [GRCh38]
Chr19:549077 [GRCh37]
Chr19:19p13.3		 benign
NM_005317.4(GZMM):c.301C>A (p.Arg101Ser) single nucleotide variant not provided [RCV000947890] Chr19:548630 [GRCh38]
Chr19:548630 [GRCh37]
Chr19:19p13.3		 benign
NM_005317.4(GZMM):c.382C>T (p.Arg128Trp) single nucleotide variant not provided [RCV000892745] Chr19:548955 [GRCh38]
Chr19:548955 [GRCh37]
Chr19:19p13.3		 benign
GRCh37/hg19 19p13.3(chr19:260911-3501271)x3 copy number gain not provided [RCV001007025] Chr19:260911..3501271 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:260911-4788357)x3 copy number gain not provided [RCV000846988] Chr19:260911..4788357 [GRCh37]
Chr19:19p13.3		 pathogenic
NM_005317.4(GZMM):c.103C>G (p.His35Asp) single nucleotide variant Inborn genetic diseases [RCV003251051] Chr19:547327 [GRCh38]
Chr19:547327 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:260912-4384674)x3 copy number gain See cases [RCV001007443] Chr19:260912..4384674 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:352288-633755)x3 copy number gain not provided [RCV001259375] Chr19:352288..633755 [GRCh37]
Chr19:19p13.3		 likely benign
GRCh37/hg19 19p13.3(chr19:414714-713630)x3 copy number gain not provided [RCV001259376] Chr19:414714..713630 [GRCh37]
Chr19:19p13.3		 likely benign
GRCh37/hg19 19p13.3(chr19:260911-1319319) copy number loss Peutz-Jeghers syndrome [RCV002280635] Chr19:260911..1319319 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:260911-2256387)x3 copy number gain See cases [RCV002285065] Chr19:260911..2256387 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:352289-548433)x1 copy number loss not provided [RCV001833039] Chr19:352289..548433 [GRCh37]
Chr19:19p13.3		 likely benign
NM_005317.4(GZMM):c.431G>A (p.Arg144Gln) single nucleotide variant Inborn genetic diseases [RCV002991885] Chr19:549004 [GRCh38]
Chr19:549004 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.211C>T (p.Arg71Trp) single nucleotide variant Inborn genetic diseases [RCV002865213] Chr19:547435 [GRCh38]
Chr19:547435 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.374G>A (p.Arg125Gln) single nucleotide variant Inborn genetic diseases [RCV002981088] Chr19:548947 [GRCh38]
Chr19:548947 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.724G>A (p.Val242Met) single nucleotide variant Inborn genetic diseases [RCV002799501] Chr19:549741 [GRCh38]
Chr19:549741 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.668T>C (p.Leu223Pro) single nucleotide variant Inborn genetic diseases [RCV002884346] Chr19:549685 [GRCh38]
Chr19:549685 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.439A>G (p.Met147Val) single nucleotide variant Inborn genetic diseases [RCV002792293] Chr19:549012 [GRCh38]
Chr19:549012 [GRCh37]
Chr19:19p13.3		 likely benign
NM_005317.4(GZMM):c.608G>A (p.Cys203Tyr) single nucleotide variant Inborn genetic diseases [RCV002935078] Chr19:549181 [GRCh38]
Chr19:549181 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.262G>A (p.Gly88Ser) single nucleotide variant Inborn genetic diseases [RCV003008868] Chr19:548591 [GRCh38]
Chr19:548591 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.333C>A (p.Asp111Glu) single nucleotide variant Inborn genetic diseases [RCV003256715] Chr19:548662 [GRCh38]
Chr19:548662 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.301C>T (p.Arg101Cys) single nucleotide variant Inborn genetic diseases [RCV003203510] Chr19:548630 [GRCh38]
Chr19:548630 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_005317.4(GZMM):c.449G>C (p.Trp150Ser) single nucleotide variant Inborn genetic diseases [RCV003179427] Chr19:549022 [GRCh38]
Chr19:549022 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:260912-548433)x1 copy number loss not provided [RCV003483345] Chr19:260912..548433 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3-13.2(chr19:260912-7246777)x3 copy number gain not provided [RCV003485190] Chr19:260912..7246777 [GRCh37]
Chr19:19p13.3-13.2		 pathogenic
GRCh37/hg19 19p13.3(chr19:260912-713630)x1 copy number loss not provided [RCV003483344] Chr19:260912..713630 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:260911-1210337)x1 copy number loss not specified [RCV003986113] Chr19:260911..1210337 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:416230-548433)x1 copy number loss not specified [RCV003986125] Chr19:416230..548433 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:352288-1186507)x3 copy number gain not specified [RCV003986107] Chr19:352288..1186507 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:496500-590577)x3 copy number gain not provided [RCV003885485] Chr19:496500..590577 [GRCh37]
Chr19:19p13.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:693
Count of miRNA genes:400
Interacting mature miRNAs:447
Transcripts:ENST00000264553, ENST00000592501
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH71363  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3719549,705 - 549,836UniSTSGRCh37
Build 3619500,705 - 500,836RGDNCBI36
Celera19268,161 - 268,292RGD
Cytogenetic Map19p13.3UniSTS
HuRef19320,019 - 320,150UniSTS
GeneMap99-GB4 RH Map1918.48UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 76 699 52 10 1096 10 21 10 78 11 39 238 19 3
Low 1856 1391 1459 553 430 416 3031 869 3004 283 1303 1237 141 1126 1724 3 2
Below cutoff 477 858 206 58 156 36 1227 1267 626 115 98 114 32 58 1000 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000264553   ⟹   ENSP00000264553
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl19544,053 - 549,922 (+)Ensembl
RefSeq Acc Id: ENST00000592501   ⟹   ENSP00000476255
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl19544,034 - 549,924 (+)Ensembl
RefSeq Acc Id: NM_001258351   ⟹   NP_001245280
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3819544,053 - 549,922 (+)NCBI
GRCh3719544,034 - 549,920 (+)NCBI
HuRef19314,019 - 320,234 (+)NCBI
CHM1_119543,125 - 549,515 (+)NCBI
T2T-CHM13v2.019497,822 - 503,990 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005317   ⟹   NP_005308
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3819544,053 - 549,922 (+)NCBI
GRCh3719544,034 - 549,920 (+)NCBI
Build 3619495,027 - 500,919 (+)NCBI Archive
HuRef19314,019 - 320,234 (+)NCBI
CHM1_119543,125 - 549,515 (+)NCBI
T2T-CHM13v2.019497,822 - 503,990 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_005308   ⟸   NM_005317
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P51124 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001245280   ⟸   NM_001258351
- Peptide Label: isoform 2
- UniProtKB: U3KQV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000264553   ⟸   ENST00000264553
RefSeq Acc Id: ENSP00000476255   ⟸   ENST00000592501
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51124-F1-model_v2 AlphaFold P51124 1-257 view protein structure

Promoters
RGD ID:6795627
Promoter ID:HG_KWN:28318
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562
Transcripts:NM_005317
Position:
Human AssemblyChrPosition (strand)Source
Build 3619494,906 - 495,406 (+)MPROMDB
RGD ID:7237697
Promoter ID:EPDNEW_H24593
Type:multiple initiation site
Name:GZMM_1
Description:granzyme M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3819544,053 - 544,113EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4712 AgrOrtholog
COSMIC GZMM COSMIC
Ensembl Genes ENSG00000197540 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000264553 ENTREZGENE
  ENST00000264553.6 UniProtKB/Swiss-Prot
  ENST00000592501 ENTREZGENE
  ENST00000592501.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000197540 GTEx
HGNC ID HGNC:4712 ENTREZGENE
Human Proteome Map GZMM Human Proteome Map
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3004 UniProtKB/Swiss-Prot
NCBI Gene 3004 ENTREZGENE
OMIM 600311 OMIM
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24271:SF51 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GZMM RGD, PharmGKB
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GRAM_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  U3KQV5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 GZMM  granzyme M    granzyme M (lymphocyte met-ase 1)  Symbol and/or name change 5135510 APPROVED