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ONTOLOGY REPORT - ANNOTATIONS

Term:ERBB signaling pathway
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Accession:GO:0038127 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: EGF receptor family signaling pathway;   ERBB signalling pathway;   ErbB signaling
 related_synonym: EGFR family signaling pathway


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ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor involved_in IEA UniProt GO_REF:0000117 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 involved_in IEA UniProt GO_REF:0000117 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA UniProt GO_REF:0000117 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G LOC100620540 tyrosine-protein phosphatase non-receptor type 11-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:63,402,961...63,412,304 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in ISO (PMID:15133037) UniProt PMID:15133037 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MVP major vault protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,056,548...18,081,169
Ensembl chr 3:18,057,177...18,081,155 		JBrowse link
G NRG1 neuregulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003 		JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB7A RAB7A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:71,777,422...71,886,758
Ensembl chr13:71,777,424...71,852,694 		JBrowse link
G SNX5 sorting nexin 5 ISO RGD PMID:16487940 RGD:13508623 NCBI chr17:26,352,945...26,381,677
Ensembl chr17:26,352,949...26,381,670 		JBrowse link
epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:18827006) Ensembl
MGI
GO_Central		 PMID:18827006 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708 		JBrowse link
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:18827006) GO_Central
MGI		 PMID:18827006 GO_REF:0000033 NCBI chr 9:120,888,891...120,984,724
Ensembl chr 9:120,892,952...120,984,695 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 involved_in ISO (PMID:18483258) BHF-UCL PMID:18483258 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 involved_in ISO (PMID:20878056)
(PMID:18483258)		 UniProt
BHF-UCL		 PMID:18483258 PMID:20878056
G ALK ALK receptor tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 3:109,411,146...110,105,755 JBrowse link
G AREG amphiregulin involved_in ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:15509566 GO_REF:0000033 GO_REF:0000107 RGD:1578718 NCBI chr 8:70,417,935...70,428,106
Ensembl chr 8:70,417,923...70,428,102 		JBrowse link
G ARF4 ADP ribosylation factor 4 ISO RGD PMID:12446727 RGD:728363 NCBI chr13:39,410,094...39,430,177
Ensembl chr13:39,409,376...39,430,129 		JBrowse link
G AXL AXL receptor tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 6:49,245,802...49,277,917
Ensembl chr 6:49,245,673...49,277,914 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member involved_in ISO PMID:9325334 UniProt PMID:9325334 RGD:8554610 NCBI chr 6:12,369,332...12,404,822
Ensembl chr 6:12,367,758...12,404,818 		JBrowse link
G BCAR3 BCAR3 adaptor protein, NSP family member involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:123,440,571...123,666,603
Ensembl chr 4:123,440,571...123,666,598 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553 		JBrowse link
G BTC betacellulin involved_in ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:11564606 GO_REF:0000033 GO_REF:0000107 RGD:2324625 NCBI chr 8:70,645,721...70,697,538
Ensembl chr 8:70,649,317...70,697,420 		JBrowse link
G CAMLG calcium modulating ligand acts_upstream_of_or_within ISO (PMID:12919676) MGI PMID:12919676 NCBI chr 2:136,957,626...136,967,944
Ensembl chr 2:136,957,508...136,968,382 		JBrowse link
G CRIPTO cripto, EGF-CFC family member NOT|acts_upstream_of_or_within ISO (PMID:8006041) MGI PMID:8006041 NCBI chr13:29,537,874...29,544,686
Ensembl chr13:29,540,314...29,543,893 		JBrowse link
G CSF1R colony stimulating factor 1 receptor involved_in IEA GOC GO_REF:0000108 NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633 		JBrowse link
G CTNNB1 catenin beta 1 involved_in ISO (PMID:18356165) ARUK-UCL PMID:18356165 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G DBX2 developing brain homeobox 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:37605090) MGI
Ensembl		 PMID:37605090 GO_REF:0000107 NCBI chr 5:75,945,866...75,983,466
Ensembl chr 5:75,945,871...75,980,496 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:23,371,358...23,391,585
Ensembl chr 7:23,373,777...23,391,585 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 4:87,749,738...87,911,818
Ensembl chr 4:87,756,168...87,911,296 		JBrowse link
G EFEMP1 EGF containing fibulin extracellular matrix protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:85,407,677...85,473,251
Ensembl chr 3:85,407,677...85,473,252 		JBrowse link
G EGF epidermal growth factor involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:15695332), (PMID:6315706)
(PMID:7641815)		 RGD
GO_Central
MGI
Ensembl		 PMID:2260661 PMID:6315706 PMID:7641815 PMID:15695332 GO_REF:0000033 GO_REF:0000107 RGD:1626483 NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046 		JBrowse link
G EGFR epidermal growth factor receptor involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:17686994)
(PMID:14712229), (PMID:15695332)
(PMID:7641815)
(PMID:7736574)		 RGD
GO_Central
MGI
Ensembl
GOC		 PMID:7641815 PMID:7736574 PMID:11796513 PMID:14712229 PMID:15486316 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 RGD:1581908 RGD:70386 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G EPGN epithelial mitogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,266,867...70,301,250
Ensembl chr 8:70,292,467...70,300,149 		JBrowse link
G EPHA1 EPH receptor A1 involved_in IEA GOC GO_REF:0000108 NCBI chr18:6,843,305...6,860,976
Ensembl chr18:6,843,299...6,860,989 		JBrowse link
G EPHA2 EPH receptor A2 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:75,251,465...75,279,364
Ensembl chr 6:75,251,467...75,279,314 		JBrowse link
G EPHA3 EPH receptor A3 involved_in IEA GOC GO_REF:0000108 NCBI chr13:166,592,492...166,942,791
Ensembl chr13:166,592,493...166,942,767 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA GOC GO_REF:0000108 NCBI chr15:123,350,867...123,501,872
Ensembl chr15:123,352,816...123,503,126 		JBrowse link
G EPHA5 EPH receptor A5 involved_in IEA GOC GO_REF:0000108 NCBI chr 8:63,285,006...63,604,734
Ensembl chr 8:63,287,711...63,604,734 		JBrowse link
G EPHA6 EPH receptor A6 involved_in IEA GOC GO_REF:0000108 NCBI chr13:162,568,835...163,445,722
Ensembl chr13:162,569,479...163,443,646 		JBrowse link
G EPHA7 EPH receptor A7 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:60,771,567...60,944,092
Ensembl chr 1:60,771,572...60,944,038 		JBrowse link
G EPHA8 EPH receptor A8 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:80,516,967...80,548,955
Ensembl chr 6:80,516,967...80,550,588 		JBrowse link
G EPHB1 EPH receptor B1 involved_in IEA GOC GO_REF:0000108 NCBI chr13:75,904,678...76,351,540
Ensembl chr13:75,905,676...76,345,534 		JBrowse link
G EPHB2 EPH receptor B2 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:80,649,098...80,849,979
Ensembl chr 6:80,650,740...80,843,567 		JBrowse link
G EPHB3 EPH receptor B3 involved_in IEA GOC GO_REF:0000108 NCBI chr13:122,467,561...122,488,296
Ensembl chr13:122,467,588...122,488,292 		JBrowse link
G EPHB4 EPH receptor B4 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:8,671,052...8,689,778
Ensembl chr 3:8,668,859...8,689,783 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 involved_in IEA
IBA		 GOC
GO_Central		 GO_REF:0000033 GO_REF:0000108 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 involved_in ISO
IBA
IEA		 RGD
GO_Central
GOC		 PMID:14711829 GO_REF:0000033 GO_REF:0000108 RGD:2289958 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038 		JBrowse link
G ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) involved_in IEA GOC GO_REF:0000108
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA
IBA		 GOC
GO_Central		 GO_REF:0000033 GO_REF:0000108 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G EREG epiregulin involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:70,351,316...70,372,530
Ensembl chr 8:70,351,311...70,372,569 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22136853)
(PMID:24550287)
(PMID:19683494), (PMID:22975324)		 Ensembl
MGI		 PMID:19683494 PMID:22136853 PMID:22975324 PMID:24550287 GO_REF:0000107 NCBI chr 6:68,667,651...68,682,629
Ensembl chr 6:68,669,153...68,682,623 		JBrowse link
G FAM83A family with sequence similarity 83 member A involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:16,169,697...16,186,015
Ensembl chr 4:16,169,708...16,184,941 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 involved_in IEA GOC GO_REF:0000108 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 involved_in IEA GOC GO_REF:0000108 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964 		JBrowse link
G FGFR4 fibroblast growth factor receptor 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 2:80,841,536...80,853,791
Ensembl chr 2:80,841,536...80,853,796 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264 		JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 involved_in IEA GOC GO_REF:0000108 NCBI chr11:5,370,475...5,455,439
Ensembl chr11:5,370,496...5,455,358 		JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 2:78,076,008...78,115,137
Ensembl chr 2:78,076,080...78,115,126 		JBrowse link
G GAB1 GRB2 associated binding protein 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:10779359)
(PMID:17881575)		 MGI PMID:10779359 PMID:17881575 NCBI chr 8:84,257,958...84,391,511
Ensembl chr 8:84,257,965...84,391,914 		JBrowse link
G GAREM1 GRB2 associated regulator of MAPK1 subtype 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:116,100,371...116,324,853
Ensembl chr 6:116,100,372...116,325,133 		JBrowse link
G GRB2 growth factor receptor bound protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,940,723...6,009,095
Ensembl chr12:5,940,647...6,010,835 		JBrowse link
G HBEGF heparin binding EGF like growth factor involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:12621152) RGD
GO_Central
MGI
Ensembl		 PMID:12621152 PMID:15486316 GO_REF:0000033 GO_REF:0000107 RGD:1581908 NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,458...142,115,174 		JBrowse link
G HDAC6 histone deacetylase 6 involved_in ISO (PMID:18356165) BHF-UCL PMID:18356165 NCBI chr  X:42,917,911...42,941,894
Ensembl chr  X:42,917,964...42,941,887 		JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in IEA GOC GO_REF:0000108 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058 		JBrowse link
G INSR insulin receptor involved_in IEA GOC GO_REF:0000108 NCBI chr 2:71,797,209...71,939,923
Ensembl chr 2:71,797,204...71,936,104 		JBrowse link
G INSRR insulin receptor related receptor involved_in IEA GOC GO_REF:0000108 NCBI chr 4:93,239,678...93,258,075
Ensembl chr 4:93,239,969...93,258,075 		JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:53,020,479...53,129,964
Ensembl chr 7:52,958,106...53,129,958 		JBrowse link
G KDR kinase insert domain receptor involved_in IEA GOC GO_REF:0000108 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G KIF16B kinesin family member 16B involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:24,882,139...25,188,990
Ensembl chr17:24,882,142...25,186,703 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 8:41,402,334...41,492,306
Ensembl chr 8:41,402,043...41,493,734 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in ISO (PMID:24854121) ARUK-UCL PMID:24854121 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in ISO (PMID:24854121) ARUK-UCL PMID:24854121 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MERTK MER proto-oncogene, tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 3:44,349,377...44,483,400
Ensembl chr 3:44,349,385...44,483,402 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512 		JBrowse link
G MST1R macrophage stimulating 1 receptor involved_in IEA GOC GO_REF:0000108 NCBI chr13:32,401,623...32,423,614
Ensembl chr13:32,409,555...32,421,920 		JBrowse link
G MUSK muscle associated receptor tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 1:251,650,151...251,758,538
Ensembl chr 1:251,650,710...251,756,608 		JBrowse link
G NPR2 natriuretic peptide receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:236,508,994...236,529,172
Ensembl chr 1:236,508,998...236,529,128 		JBrowse link
G NRG2 neuregulin 2 ISO RGD PMID:9348101 RGD:1304015 NCBI chr 2:141,660,936...141,825,281
Ensembl chr 2:141,662,369...141,824,727 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GOC GO_REF:0000108 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:191,535,262...191,941,675
Ensembl chr 1:191,535,301...191,925,327 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha involved_in IEA GOC GO_REF:0000108 NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,441 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta involved_in IEA GOC GO_REF:0000108 NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,756...151,192,647 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,432,058...39,512,601 		JBrowse link
G PIGR polymeric immunoglobulin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:67,553,094...67,574,698
Ensembl chr 9:67,553,099...67,574,668 		JBrowse link
G PLCE1 phospholipase C epsilon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:105,422,628...105,764,736
Ensembl chr14:105,458,916...105,764,737 		JBrowse link
G PLCG1 phospholipase C gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,810,003...43,844,553
Ensembl chr17:43,810,048...43,844,554 		JBrowse link
G PRICKLE1 prickle planar cell polarity protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:73,707,026...73,826,529
Ensembl chr 5:73,707,050...73,826,430 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in ISO
IBA		 RGD
GO_Central		 PMID:16945503 GO_REF:0000033 RGD:1642613 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18827006) Ensembl
MGI		 PMID:18827006 GO_REF:0000107 NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003 		JBrowse link
G RET ret proto-oncogene involved_in IEA GOC GO_REF:0000108 NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,412 		JBrowse link
G ROS1 ROS proto-oncogene 1, receptor tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 1:44,409,877...44,535,784
Ensembl chr 1:44,410,351...44,534,874 		JBrowse link
G SHC1 SHC adaptor protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:23846654) Ensembl
MGI
GO_Central		 PMID:23846654 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:94,818,226...94,831,766
Ensembl chr 4:94,810,875...94,831,765 		JBrowse link
G SLC30A10 solute carrier family 30 member 10 acts_upstream_of_or_within ISO (PMID:26728129) UniProt PMID:26728129 NCBI chr10:9,527,523...9,545,493 JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15695332) Ensembl
MGI
InterPro		 PMID:15695332 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,863 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9030684) Ensembl
MGI		 PMID:9030684 GO_REF:0000107 NCBI chr 3:101,209,568...101,366,057
Ensembl chr 3:101,209,641...101,362,723 		JBrowse link
G SOX9 SRY-box transcription factor 9 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:8,642,154...8,647,315
Ensembl chr12:8,642,158...8,647,315 		JBrowse link
G SPG21 SPG21 abhydrolase domain containing, maspardin acts_upstream_of_or_within ISO (PMID:26978163) MGI PMID:26978163 NCBI chr 1:107,011,731...107,036,353
Ensembl chr 1:107,011,547...107,036,347 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO
IBA		 RGD
GO_Central		 PMID:15856020 GO_REF:0000033 RGD:1581134 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G TEK TEK receptor tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 1:195,938,177...196,052,294
Ensembl chr 1:195,937,432...196,051,980 		JBrowse link
G TFAP2A transcription factor AP-2 alpha acts_upstream_of ISO (PMID:16449191) MGI PMID:16449191 NCBI chr 7:7,221,654...7,244,626
Ensembl chr 7:7,221,656...7,244,612 		JBrowse link
G TGFA transforming growth factor alpha involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:6315706) Ensembl
GO_Central
MGI		 PMID:6315706 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:71,948,232...72,054,257
Ensembl chr 3:71,948,137...72,050,474 		JBrowse link
G TIE1 tyrosine kinase with immunoglobulin like and EGF like domains 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:167,919,662...167,947,253
Ensembl chr 6:167,919,668...167,940,870 		JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase involved_in IEA GOC GO_REF:0000108 NCBI chr 1:129,811,540...129,829,395
Ensembl chr 1:129,811,544...129,829,014 		JBrowse link
G VIL1 villin 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr15:120,463,470...120,494,772
Ensembl chr15:120,463,566...120,492,580 		JBrowse link
G ZNF774 zinc finger protein 774 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:52,985,669...52,994,797
Ensembl chr 7:52,958,106...53,129,958 		JBrowse link
ERBB2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE3 copine 3 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:50,276,330...50,345,400
Ensembl chr 4:50,276,426...50,345,366 		JBrowse link
G PTPRR protein tyrosine phosphatase receptor type R involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:34,794,970...35,048,550
Ensembl chr 5:34,794,977...35,047,818 		JBrowse link
ERBB2-EGFR signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AREG amphiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,417,935...70,428,106
Ensembl chr 8:70,417,923...70,428,102 		JBrowse link
G BTC betacellulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,645,721...70,697,538
Ensembl chr 8:70,649,317...70,697,420 		JBrowse link
G EGF epidermal growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046 		JBrowse link
G EGFR epidermal growth factor receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G EREG epiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,351,316...70,372,530
Ensembl chr 8:70,351,311...70,372,569 		JBrowse link
G HBEGF heparin binding EGF like growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,458...142,115,174 		JBrowse link
G TGFA transforming growth factor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:71,948,232...72,054,257
Ensembl chr 3:71,948,137...72,050,474 		JBrowse link
ERBB2-ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERBB2 erb-b2 receptor tyrosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 involved_in ISO (PMID:24493648) MGI PMID:24493648 NCBI chr 2:74,626,739...74,651,352
Ensembl chr 2:74,626,783...74,651,348 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in ISO (PMID:24493648) MGI PMID:24493648 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MYOC myocilin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:114,087,370...114,098,765
Ensembl chr 9:114,087,378...114,098,745 		JBrowse link
G NRG1 neuregulin 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
G NRG2 neuregulin 2 involved_in ISO (PMID:9742126) MGI PMID:9742126 NCBI chr 2:141,660,936...141,825,281
Ensembl chr 2:141,662,369...141,824,727 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:68,581,128...68,657,911
Ensembl chr13:68,580,812...68,657,829 		JBrowse link
ERBB2-ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERBB2 erb-b2 receptor tyrosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G EREG epiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,351,316...70,372,530
Ensembl chr 8:70,351,311...70,372,569 		JBrowse link
G HBEGF heparin binding EGF like growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,458...142,115,174 		JBrowse link
G NRG1 neuregulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRG1 neuregulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G NRG1 neuregulin 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
G NRG2 neuregulin 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:141,660,936...141,825,281
Ensembl chr 2:141,662,369...141,824,727 		JBrowse link
G NRG3 neuregulin 3 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:83,316,962...84,405,347
Ensembl chr14:83,317,019...84,402,943 		JBrowse link
ERBB4-ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTC betacellulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,645,721...70,697,538
Ensembl chr 8:70,649,317...70,697,420 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G EREG epiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:70,351,316...70,372,530
Ensembl chr 8:70,351,311...70,372,569 		JBrowse link
G NRG1 neuregulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
G NRG2 neuregulin 2 involved_in ISO (PMID:9168115) MGI PMID:9168115 NCBI chr 2:141,660,936...141,825,281
Ensembl chr 2:141,662,369...141,824,727 		JBrowse link
G NRG3 neuregulin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:83,316,962...84,405,347
Ensembl chr14:83,317,019...84,402,943 		JBrowse link
G NRG4 neuregulin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:56,179,713...56,311,408
Ensembl chr 7:56,167,959...56,311,270 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBL Cbl proto-oncogene involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,416,938...46,512,834 		JBrowse link
G CBLB Cbl proto-oncogene B involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:153,480,525...153,700,115
Ensembl chr13:153,395,978...153,700,056 		JBrowse link
G CBLC Cbl proto-oncogene C involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:51,274,717...51,292,546
Ensembl chr 6:51,276,544...51,292,549 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in ISO PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,785...261,859,830 		JBrowse link
G DUSP3 dual specificity phosphatase 3 involved_in ISO (PMID:28759036) BHF-UCL PMID:28759036 NCBI chr12:19,336,308...19,349,739
Ensembl chr12:19,336,354...19,349,734 		JBrowse link
G EGFR epidermal growth factor receptor involved_in ISO (PMID:11823423)
(PMID:23457600)		 MGI PMID:11823423 PMID:23457600 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:19204184 GO_REF:0000033 GO_REF:0000107 RGD:9685562 NCBI chr 6:68,667,651...68,682,629
Ensembl chr 6:68,669,153...68,682,623 		JBrowse link
G ITGA1 integrin subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:32,130,265...32,309,917
Ensembl chr16:32,129,612...32,304,592 		JBrowse link
G MIR133A-1 microRNA mir-133a-1 involved_in ISO (PMID:23069713) BHF-UCL PMID:23069713 NCBI chr17:61,904,781...61,904,883
Ensembl chr17:61,904,781...61,904,883 		JBrowse link
G MIR133A-2 microRNA mir-133a-2 involved_in ISO (PMID:23069713) BHF-UCL PMID:23069713 NCBI chr 6:106,998,899...106,998,971
Ensembl chr 6:106,998,896...106,998,982 		JBrowse link
G MVP major vault protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,056,548...18,081,169
Ensembl chr 3:18,057,177...18,081,155 		JBrowse link
G NPPA natriuretic peptide A involved_in ISO (PMID:20353436) UniProt PMID:20353436 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,918,845...71,921,405 		JBrowse link
G NUP62 nucleoporin 62 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,921,627...54,945,705
Ensembl chr 6:54,921,627...54,923,227 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO RGD PMID:8557682 RGD:1642757 NCBI chr 6:167,656,674...167,743,750
Ensembl chr 6:167,657,680...167,743,721 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:14,548,489...14,724,823
Ensembl chr 2:14,548,428...14,724,474 		JBrowse link
G RNF115 ring finger protein 115 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:99,493,172...99,577,946
Ensembl chr 4:99,493,481...99,573,564 		JBrowse link
G RNF126 ring finger protein 126 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:77,673,302...77,683,312
Ensembl chr 2:77,673,353...77,683,311 		JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO (PMID:24854121) ARUK-UCL PMID:24854121 NCBI chr 1:205,081,227...205,285,359
Ensembl chr 1:205,081,231...205,285,364 		JBrowse link
G TFAP2A transcription factor AP-2 alpha acts_upstream_of_or_within ISO (PMID:16449191) MGI PMID:16449191 NCBI chr 7:7,221,654...7,244,626
Ensembl chr 7:7,221,656...7,244,612 		JBrowse link
G TSG101 tumor susceptibility 101 involved_in ISO (PMID:16554368) ParkinsonsUK-UCL PMID:16554368 NCBI chr 2:40,673,187...40,720,681 JBrowse link
G ZFYVE28 zinc finger FYVE-type containing 28 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:1,225,417...1,312,938
Ensembl chr 8:1,225,429...1,312,521 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHMP6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr12:1,691,821...1,698,347
Ensembl chr12:1,691,823...1,698,305 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISO (PMID:18046415)
PMID:17599051
(PMID:16648858)		 UniProt PMID:16648858 PMID:17599051 PMID:18046415 RGD:8553726 NCBI chr 6:68,667,651...68,682,629
Ensembl chr 6:68,669,153...68,682,623 		JBrowse link
G GPRC5A G protein-coupled receptor class C group 5 member A involved_in ISO (PMID:25744720) UniProt PMID:25744720 NCBI chr 5:59,565,793...59,586,641
Ensembl chr 5:59,565,799...59,586,600 		JBrowse link
G PSEN1 presenilin 1 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chr 7:96,478,179...96,567,884
Ensembl chr 7:96,478,190...96,569,130 		JBrowse link
G PSEN2 presenilin 2 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chr10:14,532,556...14,561,862
Ensembl chr10:14,532,767...14,577,251 		JBrowse link
G SOCS4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chr 1:184,379,017...184,398,902
Ensembl chr 1:184,379,086...184,398,898 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,863 		JBrowse link
G TSG101 tumor susceptibility 101 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr 2:40,673,187...40,720,681 JBrowse link
G VPS25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr12:20,082,864...20,088,443
Ensembl chr12:20,082,865...20,088,566 		JBrowse link
G ZFYVE28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) UniProt PMID:19460345 NCBI chr 8:1,225,417...1,312,938
Ensembl chr 8:1,225,429...1,312,521 		JBrowse link
G ZGPAT zinc finger CCCH-type and G-patch domain containing involved_in ISO (PMID:19644445) UniProt PMID:19644445 NCBI chr17:62,640,988...62,652,478
Ensembl chr17:62,635,018...62,652,483 		JBrowse link
negative regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LGMN legumain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:114,176,217...114,210,096
Ensembl chr 7:114,173,693...114,217,102 		JBrowse link
negative regulation of ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP4 acid phosphatase 4 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:55,535,406...55,541,929
Ensembl chr 6:55,536,904...55,541,968 		JBrowse link
G CADM1 cell adhesion molecule 1 ISO RGD PMID:23769722 RGD:152975632 NCBI chr 9:42,644,487...42,984,934
Ensembl chr 9:42,644,431...42,985,017 		JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18625725) Ensembl
BHF-UCL		 PMID:18625725 GO_REF:0000107 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995 		JBrowse link
G ADRA2A adrenoceptor alpha 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:121,469,572...121,470,924
Ensembl chr14:121,469,527...121,470,924 		JBrowse link
G AFAP1L2 actin filament associated protein 1 like 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:124,630,797...124,737,350
Ensembl chr14:124,630,799...124,672,813 		JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857 		JBrowse link
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in IMP (PMID:23389627) AgBase PMID:23389627 NCBI chr 4:94,026,391...94,082,206
Ensembl chr 4:94,026,386...94,080,420 		JBrowse link
G CCDC88A coiled-coil domain containing 88A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:85,811,043...85,971,162
Ensembl chr 3:85,811,127...85,941,864 		JBrowse link
G CNOT9 CCR4-NOT transcription complex subunit 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:120,590,354...120,622,203
Ensembl chr15:120,590,641...120,623,898 		JBrowse link
G DGKD diacylglycerol kinase delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:133,749,349...133,867,804
Ensembl chr15:133,749,345...133,867,801 		JBrowse link
G ESR1 estrogen receptor 1 ISO RGD PMID:17928626 RGD:5128669 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:17928626 RGD:5128669 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G FAM83B family with sequence similarity 83 member B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:26,058,175...26,142,040
Ensembl chr 7:26,058,168...26,137,655 		JBrowse link
G FASLG Fas ligand ISO RGD PMID:18471522 RGD:2315731 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:20445128 GO_REF:0000107 RGD:4892084 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,980 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:12890790 UniProt PMID:12890790 RGD:10047165 NCBI chr12:20,938,463...20,950,053
Ensembl chr12:20,939,554...20,950,051 		JBrowse link
G HIP1 huntingtin interacting protein 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:10,416,418...10,578,374
Ensembl chr 3:10,416,475...10,578,366 		JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:29,996,388...30,024,343
Ensembl chr14:29,993,655...30,024,216 		JBrowse link
G MIR29A microRNA mir-29a involved_in ISO (PMID:25058496) FlyBase PMID:25058496 NCBI chr18:18,040,032...18,040,117
Ensembl chr18:18,040,032...18,040,118 		JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G NEU3 neuraminidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:9,315,263...9,333,878
Ensembl chr 9:9,315,334...9,334,918 		JBrowse link
G PDE6G phosphodiesterase 6G involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:11502744) Ensembl
GO_Central
MGI		 PMID:11502744 GO_REF:0000033 GO_REF:0000107 NCBI chr12:1,235,886...1,239,808
Ensembl chr12:1,236,210...1,239,306 		JBrowse link
G PDE6H phosphodiesterase 6H involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:11502744) Ensembl
GO_Central
MGI		 PMID:11502744 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:57,555,448...57,582,324
Ensembl chr 5:57,556,149...57,594,423 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418 		JBrowse link
G RALA RAS like proto-oncogene A involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:54,548,523...54,630,746
Ensembl chr18:54,550,238...54,588,980 		JBrowse link
G RALB RAS like proto-oncogene B involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:31,064,341...31,118,437
Ensembl chr15:31,064,355...31,122,621 		JBrowse link
G SHKBP1 SH3KBP1 binding protein 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:48,813,163...48,826,461
Ensembl chr 6:48,813,168...48,826,457 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:8577724 RGD:1581110 NCBI chr 3:101,209,568...101,366,057
Ensembl chr 3:101,209,641...101,362,723 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:52,153,695...52,158,766
Ensembl chr11:52,153,704...52,159,156 		JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of
involved_in		 ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
positive regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,754 		JBrowse link
positive regulation of ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RTN4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:86,180,022...86,252,126
Ensembl chr 3:86,180,022...86,252,126 		JBrowse link
regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH13 cadherin 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:4,809,752...5,832,188
Ensembl chr 6:4,808,255...5,832,415 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO PMID:15467833
(PMID:15467833)		 UniProt PMID:15467833 RGD:11059592 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G FER FER tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:113,774,120...114,207,307
Ensembl chr 2:113,774,412...114,206,930 		JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:84,852,782...84,858,072
Ensembl chr 6:84,852,793...84,857,982 		JBrowse link
G MIR21 microRNA mir-21 involved_in ISO (PMID:24012640) BHF-UCL PMID:24012640 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MVB12A multivesicular body subunit 12A involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:60,271,020...60,275,972
Ensembl chr 2:60,271,026...60,275,971 		JBrowse link
G MVB12B multivesicular body subunit 12B involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:266,933,459...267,105,790
Ensembl chr 1:266,933,542...267,105,788 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:102,480,914...102,563,969
Ensembl chr 9:102,480,924...102,563,751 		JBrowse link
G RHBDF1 rhomboid 5 homolog 1 involved_in IEA
IBA		 Ensembl
GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:41,548,440...41,567,596
Ensembl chr 3:41,560,915...41,567,593 		JBrowse link
G RHBDF2 rhomboid 5 homolog 2 involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr12:5,008,534...5,036,278
Ensembl chr12:5,010,178...5,036,255 		JBrowse link
G WDR54 WD repeat domain 54 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:68,614,019...68,618,433
Ensembl chr 3:68,614,020...68,622,598 		JBrowse link
regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SH3TC2 SH3 domain and tetratricopeptide repeats 2 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:23553667) Ensembl
GO_Central
MGI		 PMID:23553667 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:150,183,480...150,247,747
Ensembl chr 2:150,183,485...150,247,637 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18933
    cellular process 18475
      signal transduction 6990
        cell surface receptor signaling pathway 2785
          enzyme-linked receptor protein signaling pathway 1039
            cell surface receptor protein tyrosine kinase signaling pathway 661
              ERBB signaling pathway 179
                ERBB2 signaling pathway + 20
                ERBB3 signaling pathway + 11
                ERBB4 signaling pathway + 11
                epidermal growth factor receptor signaling pathway + 163
                negative regulation of ERBB signaling pathway + 35
                positive regulation of ERBB signaling pathway + 31
                regulation of ERBB signaling pathway + 78
Path 2
Term Annotations click to browse term
  biological_process 18933
    biological regulation 13010
      regulation of biological process 12629
        signaling 7532
          signal transduction 6990
            cell surface receptor signaling pathway 2785
              enzyme-linked receptor protein signaling pathway 1039
                cell surface receptor protein tyrosine kinase signaling pathway 661
                  ERBB signaling pathway 179
                    ERBB2 signaling pathway + 20
                    ERBB3 signaling pathway + 11
                    ERBB4 signaling pathway + 11
                    epidermal growth factor receptor signaling pathway + 163
                    negative regulation of ERBB signaling pathway + 35
                    positive regulation of ERBB signaling pathway + 31
                    regulation of ERBB signaling pathway + 78
paths to the root