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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:epidermal growth factor receptor signaling pathway
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Accession:GO:0007173 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: EGF receptor signaling pathway;   EGF receptor signalling pathway;   EGFR signaling pathway;   ERBB1 signaling pathway;   epidermal growth factor receptor signalling pathway;   receptor tyrosine-protein kinase erbB-1 signaling pathway


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epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:95290|MGI:95294 (MGI:3814963|PMID:18827006) RGD PMID:18827006 MGI:3814963 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:95290|MGI:95294 (MGI:3814963|PMID:18827006) RGD PMID:18827006 MGI:3814963 NCBI chr13:68,673,702...68,839,742
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO (PMID:12743035) RGD PMID:12743035 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:20878056) RGD PMID:20878056 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Areg amphiregulin involved_in IDA
IBA
ISO		 PMID:21873635
MGI:95294 (MGI:5468364|PMID:23333074), (MGI:5468387|PMID:23086930), (MGI:5697759|PMID:26243875), (MGI:6342346|PMID:30770250)
(PMID:12743035)		 RGD PMID:12743035 PMID:23086930 PMID:23333074 PMID:26243875 PMID:30770250 More... MGI:5468364 MGI:5468387 MGI:5697759 MGI:6342346, RGD:1578718, RGD:13792537 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arf4 ADP-ribosylation factor 4 IDA RGD PMID:12446727 RGD:728363 NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in IDA PMID:9325334 UniProt PMID:9325334 RGD:8554610 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase involved_in ISO (PMID:18567582) RGD PMID:18567582 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Btc betacellulin involved_in IDA
IBA
ISO		 PMID:21873635
MGI:95294 (MGI:3807093|PMID:18656477), (MGI:70162|PMID:8456283)		 RGD PMID:8456283 PMID:18656477 PMID:11564606 PMID:21873635 MGI:3807093 MGI:70162, RGD:2324625, RGD:13792537 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Camlg calcium modulating ligand acts_upstream_of_or_within ISO (MGI:2675970|PMID:12919676) RGD PMID:12919676 MGI:2675970 NCBI chr17:8,992,697...9,003,576
Ensembl chr17:8,992,696...9,003,552 		JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 involved_in ISO
ISS		 (PMID:19804359)
GO_REF:0000024		 RGD
UniProt		 PMID:19804359 GO_REF:0000024 NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018 		JBrowse link
G Egf epidermal growth factor involved_in
acts_upstream_of_or_within		 IDA
ISO		 (MGI:1267000|PMID:9529375), (MGI:2136149|PMID:6248866), (MGI:2663334|PMID:12761849), (MGI:74347|PMID:7752576)
MGI:95294 (MGI:3531070|PMID:15695332), (MGI:63909|PMID:6315706), (MGI:75839|PMID:7641815)
(PMID:18567582), (PMID:31915155)		 RGD PMID:6248866 PMID:6315706 PMID:7641815 PMID:7752576 PMID:9529375 More... MGI:1267000 MGI:2136149 MGI:2663334 MGI:3531070 MGI:63909 MGI:74347 MGI:75839, RGD:1626483 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor involved_in
acts_upstream_of_or_within		 IDA
ISO
IMP		 (PMID:12435727), (PMID:20878056), (PMID:9890893)
MGI:107508|MGI:3763534 (MGI:1203410|PMID:9556621), (MGI:2136149|PMID:6248866), (MGI:2445853|PMID:12399441), (MGI:2663334|PMID:12761849), (MGI:52273|PMID:7678348), (MGI:5468364|PMID:23333074), (MGI:5529581|PMID:23899604), (MGI:5926600|PMID:28783046), (MGI:6342346|PMID:30770250), (MGI:70162|PMID:8456283), (MGI:74347|PMID:7752576), (MGI:82360|PMID:8702723)
(PMID:7736574)
MGI:95290 (MGI:3032880|PMID:14712229), (MGI:3531070|PMID:15695332), (MGI:3766849|PMID:17686994), (MGI:75839|PMID:7641815)
PMID:20639532		 RGD PMID:6248866 PMID:7641815 PMID:7678348 PMID:7736574 PMID:7752576 More... MGI:1203410 MGI:2136149 MGI:2445853 MGI:2663334 MGI:3032880 MGI:3531070 MGI:3766849 MGI:52273 MGI:5468364 MGI:5529581 MGI:5926600 MGI:6342346 MGI:70162 MGI:74347 MGI:75839 MGI:82360, RGD:70386, RGD:8553583, RGD:1581908 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Epgn epithelial mitogen involved_in ISO
IBA		 MGI:95294 (MGI:1934957|PMID:11278323), (MGI:5529581|PMID:23899604), (MGI:5660061|PMID:24891618)
PMID:21873635		 RGD PMID:11278323 PMID:23899604 PMID:24891618 PMID:21873635 MGI:1934957 MGI:5529581 MGI:5660061, RGD:13792537 NCBI chr14:17,076,774...17,084,806
Ensembl chr14:17,076,774...17,084,806 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IMP RGD PMID:14711829 RGD:2289958 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ereg epiregulin involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:28783046), (PMID:9556621)
MGI:95294 (MGI:3687425|PMID:7706296), (MGI:5926600|PMID:28783046)		 UniProt
RGD		 PMID:7706296 PMID:9556621 PMID:28783046 PMID:21873635 GO_REF:0000024 MGI:3687425 MGI:5926600, RGD:13792537 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Fam83a family with sequence similarity 83, member A involved_in IBA
ISO		 PMID:21873635
(PMID:22886303)		 RGD PMID:22886303 PMID:21873635 RGD:13792537 NCBI chr 7:89,522,826...89,547,284
Ensembl chr 7:89,522,826...89,547,388 		JBrowse link
G Fam83b family with sequence similarity 83, member B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795 		JBrowse link
G Fam83c family with sequence similarity 83, member C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:144,333,736...144,339,758
Ensembl chr 3:144,332,982...144,339,802 		JBrowse link
G Gab1 GRB2-associated binding protein 1 acts_upstream_of_or_within
involved_in		 ISO MGI:1926435 (MGI:1355592|PMID:10779359)
MGI:3759868 (MGI:3758145|PMID:17881575)		 RGD PMID:10779359 PMID:17881575 MGI:1355592 MGI:3758145 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Garem1 GRB2 associated regulator of MAPK1 subtype 1 involved_in ISO (PMID:19509291) RGD PMID:19509291 NCBI chr18:12,420,169...12,585,323
Ensembl chr18:12,423,882...12,585,345 		JBrowse link
G Grb2 growth factor receptor bound protein 2 involved_in ISO (PMID:8253073)
MGI:108088 (MGI:3758145|PMID:17881575)		 RGD PMID:8253073 PMID:17881575 MGI:3758145 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor involved_in
acts_upstream_of_or_within		 TAS
IBA
ISO
IMP		 PMID:21873635
(PMID:17655843), (PMID:8702723)
(MGI:2654964|PMID:12621152)		 RGD PMID:8702723 PMID:12621152 PMID:17655843 PMID:11956950 PMID:21873635 More... MGI:2654964, RGD:728846, RGD:13792537, RGD:1581908 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 involved_in ISO
IBA		 (PMID:17563371), (PMID:18567582)
PMID:21873635
(MGI:5430891|PMID:17563371)		 RGD PMID:17563371 PMID:18567582 PMID:21873635 MGI:5430891, RGD:13792537 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Kif16b kinesin family member 16B involved_in ISO (PMID:15882625) RGD PMID:15882625 NCBI chr 3:129,974,692...130,254,194
Ensembl chr 3:129,974,800...130,254,019 		JBrowse link
G Npr2 natriuretic peptide receptor 2 involved_in ISO MGI:1856702|MGI:5911053 (MGI:5449332|PMID:22987720), (MGI:5749298|PMID:26522847) RGD PMID:22987720 PMID:26522847 MGI:5449332 MGI:5749298 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580 		JBrowse link
G Nrg2 neuregulin 2 IDA RGD PMID:9348101 RGD:1304015 NCBI chr18:27,619,635...27,798,505
Ensembl chr18:27,619,661...27,798,505 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO (PMID:22454520) RGD PMID:22454520 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pigr polymeric immunoglobulin receptor involved_in IEA
ISO		 GO_REF:0000107
(PMID:22022593)		 Ensembl
RGD		 PMID:22022593 GO_REF:0000107 NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875 		JBrowse link
G Plce1 phospholipase C, epsilon 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:29058690)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29058690 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438 		JBrowse link
G Plcg1 phospholipase C, gamma 1 involved_in ISO
IDA		 (PMID:22454520)
PMID:7531435		 RGD PMID:22454520 PMID:7531435 RGD:39458025 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Prickle1 prickle planar cell polarity protein 1 involved_in ISO
IEA		 (MGI:5923213|PMID:27378169)
GO_REF:0000107		 RGD
Ensembl		 PMID:27378169 GO_REF:0000107 MGI:5923213 NCBI chr 7:124,639,142...124,735,027
Ensembl chr 7:124,639,142...124,658,113 		JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in IMP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:16945503 PMID:21873635 RGD:1642613, RGD:13792537 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within
involved_in		 ISO MGI:87859|MGI:87860|MGI:95290|MGI:95294 (MGI:3814963|PMID:18827006)
MGI:95294 (MGI:1353861|PMID:10700187)		 RGD PMID:10700187 PMID:18827006 MGI:1353861 MGI:3814963 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Shc1 SHC adaptor protein 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(MGI:5543315|PMID:23846654)		 Ensembl
RGD		 PMID:23846654 PMID:21873635 GO_REF:0000107 MGI:5543315, RGD:13792537 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 acts_upstream_of_or_within ISO (PMID:26728129) RGD PMID:26728129 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 acts_upstream_of_or_within ISO (MGI:3531070|PMID:15695332) RGD PMID:15695332 MGI:3531070 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:2155441 (MGI:85697|PMID:9030684) RGD PMID:9030684 MGI:85697 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5285125|PMID:21512138)		 UniProt
RGD		 PMID:21512138 GO_REF:0000024 MGI:5285125 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:15856020 PMID:21873635 RGD:1581134, RGD:13792537 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 NOT|acts_upstream_of_or_within ISO (PMID:8006041) RGD PMID:8006041 NCBI chr 8:110,924,774...110,938,545
Ensembl chr 8:110,925,024...110,930,308 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of ISO MGI:3038304 (MGI:3616382|PMID:16449191) RGD PMID:16449191 MGI:3616382 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tgfa transforming growth factor alpha involved_in TAS
IBA
ISO		 PMID:21873635
(MGI:3758145|PMID:17881575), (MGI:74347|PMID:7752576)		 RGD PMID:7752576 PMID:17881575 PMID:2103501 PMID:21873635 MGI:3758145 MGI:74347, RGD:1578565, RGD:13792537 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18625725)		 UniProt
RGD		 PMID:18625725 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Vil1 villin 1 involved_in ISO (PMID:17229814) RGD PMID:17229814 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)		 RGD PMID:16282324 PMID:18272684 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:131,621,709...131,641,205
Ensembl chr 3:131,621,880...131,641,192 		JBrowse link
epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rassf2 Ras association domain family member 2 acts_upstream_of_or_within ISO MGI:5314787 (MGI:5314467|PMID:22227519) RGD PMID:22227519 MGI:5314467 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431 		JBrowse link
epidermal growth factor receptor signaling pathway via MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18722344)		 UniProt
Ensembl
RGD		 PMID:18722344 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
ERBB2-EGFR signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin involved_in ISO (PMID:8702723) RGD PMID:8702723 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Btc betacellulin involved_in ISO (MGI:6229129|PMID:21897861) RGD PMID:21897861 MGI:6229129 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Egf epidermal growth factor involved_in ISO
IEA		 (MGI:6856504|PMID:22822073)
GO_REF:0000107
(PMID:11336639)		 RGD
Ensembl		 PMID:11336639 PMID:22822073 GO_REF:0000107 MGI:6856504 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO MGI:1856402 (MGI:1203410|PMID:9556621), (MGI:3806939|PMID:18701712), (MGI:5294691|PMID:21946538), (MGI:6229129|PMID:21897861), (MGI:82360|PMID:8702723)
(PMID:11336639)		 RGD PMID:8702723 PMID:9556621 PMID:11336639 PMID:18701712 PMID:21897861 More... MGI:1203410 MGI:3806939 MGI:5294691 MGI:6229129 MGI:82360 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in ISO MGI:95294 (MGI:1203410|PMID:9556621), (MGI:3764585|PMID:16357442), (MGI:3806939|PMID:18701712), (MGI:6229129|PMID:21897861), (MGI:82360|PMID:8702723)
(PMID:8702723)		 RGD PMID:8702723 PMID:9556621 PMID:16357442 PMID:18701712 PMID:21897861 MGI:1203410 MGI:3764585 MGI:3806939 MGI:6229129 MGI:82360 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Ereg epiregulin involved_in ISO (PMID:9556621) RGD PMID:9556621 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor involved_in ISO MGI:2665039 (MGI:5294691|PMID:21946538) RGD PMID:21946538 MGI:5294691 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Tgfa transforming growth factor alpha involved_in ISO (PMID:8702723) RGD PMID:8702723 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (PMID:25178484)
MGI:2180578|MGI:95294 (MGI:5502501|PMID:23457600), (MGI:7471045|PMID:12754251), (MGI:7471047|PMID:11823423)		 RGD PMID:11823423 PMID:12754251 PMID:23457600 PMID:25178484 MGI:5502501 MGI:7471045 MGI:7471047 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO (PMID:10362357) RGD PMID:10362357 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in IDA PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (MGI:6101044|PMID:28759036) RGD PMID:28759036 MGI:6101044 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (MGI:5502501|PMID:23457600), (MGI:7471047|PMID:11823423) RGD PMID:11823423 PMID:23457600 MGI:5502501 MGI:7471047 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IMP
ISO
IBA		 (MGI:4366137|PMID:19710174)
PMID:21873635		 RGD PMID:19710174 PMID:19204184 PMID:21873635 MGI:4366137, RGD:9685562, RGD:13792537 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Itga1 integrin subunit alpha 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5488887|PMID:15592458)		 UniProt
RGD		 PMID:15592458 GO_REF:0000024 MGI:5488887 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Mvp major vault protein involved_in ISO
IEA		 (PMID:16441665)
GO_REF:0000107		 RGD
Ensembl		 PMID:16441665 GO_REF:0000107 NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:20353436) RGD PMID:20353436 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (MGI:3526674|PMID:11489947) RGD PMID:11489947 MGI:3526674 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15592458)		 UniProt
RGD		 PMID:15592458 GO_REF:0000024 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19836242) RGD PMID:19836242 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 2:184,262,087...184,329,841
Ensembl chr 2:184,262,371...184,329,823 		JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:3038304 (MGI:3616382|PMID:16449191) RGD PMID:16449191 MGI:3616382 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) RGD PMID:19460345 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO
IBA		 (PMID:10362357)
PMID:21873635		 RGD PMID:10362357 PMID:21873635 RGD:13792537 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
ISO
IDA		 GO_REF:0000024
(MGI:3629275|PMID:16648858)
PMID:17599051
(PMID:18046415)		 UniProt
RGD		 PMID:16648858 PMID:18046415 PMID:17599051 GO_REF:0000024 MGI:3629275, RGD:8553726 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A involved_in ISO (MGI:5635952|PMID:25744720) RGD PMID:25744720 MGI:5635952 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO
IBA		 (PMID:19460345)
PMID:21873635		 RGD PMID:19460345 PMID:21873635 RGD:13792537 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISO
ISS		 (PMID:19644445)
GO_REF:0000024		 RGD
UniProt		 PMID:19644445 GO_REF:0000024 NCBI chr 3:168,473,836...168,490,380
Ensembl chr 3:168,473,981...168,490,380 		JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afap1l2 actin filament associated protein 1-like 2 involved_in IBA
ISO		 PMID:21873635
(PMID:17412687)		 RGD PMID:17412687 PMID:21873635 RGD:13792537 NCBI chr 1:255,964,238...256,060,828
Ensembl chr 1:255,964,238...256,060,820 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:25666625) RGD PMID:25666625 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Agt angiotensinogen involved_in ISO (PMID:15652490) RGD PMID:15652490 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member involved_in ISO (PMID:18722344) RGD PMID:18722344 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798 		JBrowse link
G Ccdc88a coiled coil domain containing 88A involved_in ISO (PMID:20462955) RGD PMID:20462955 NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 involved_in ISO (PMID:20878056) RGD PMID:20878056 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100 		JBrowse link
G Dgkd diacylglycerol kinase, delta involved_in ISO (MGI:3691361|PMID:17021016) RGD PMID:17021016 MGI:3691361 NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345 		JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fam83b family with sequence similarity 83, member B involved_in ISO
IEA		 (PMID:22886302), (PMID:23676467), (PMID:23912460)
GO_REF:0000107		 RGD
Ensembl		 PMID:22886302 PMID:23676467 PMID:23912460 GO_REF:0000107 NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795 		JBrowse link
G Faslg Fas ligand IMP RGD PMID:18471522 RGD:2315731 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in IMP
IEA
ISO		 GO_REF:0000107
(MGI:5141337|PMID:21673097)
(PMID:15705806)		 Ensembl
RGD		 PMID:15705806 PMID:21673097 PMID:20445128 GO_REF:0000107 MGI:5141337, RGD:4892084 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:12890790 UniProt PMID:12890790 RGD:10047165 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Hip1 huntingtin interacting protein 1 involved_in ISO (PMID:14732715) RGD PMID:14732715 NCBI chr12:21,133,319...21,267,796
Ensembl chr12:21,133,406...21,267,725 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:14732715) RGD PMID:14732715 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734 		JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:25058496) RGD PMID:25058496 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO
IEA		 (PMID:22984561)
GO_REF:0000107		 RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Neu3 neuraminidase 3 involved_in ISO (PMID:17334392) RGD PMID:17334392 NCBI chr 1:154,137,732...154,148,879
Ensembl chr 1:154,050,855...154,148,813 		JBrowse link
G Pde6g phosphodiesterase 6G involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2156093|PMID:11502744)		 RGD PMID:11502744 PMID:21873635 MGI:2156093, RGD:13792537 NCBI chr10:105,721,502...105,727,204
Ensembl chr10:105,721,682...105,726,719 		JBrowse link
G Pde6h phosphodiesterase 6H involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2156093|PMID:11502744)		 RGD PMID:11502744 PMID:21873635 MGI:2156093, RGD:13792537 NCBI chr 4:169,857,793...169,872,969
Ensembl chr 4:169,857,812...169,872,969 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) RGD PMID:22984561 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Rala RAS like proto-oncogene A involved_in ISO UniProtKB:P11234 (PMID:34096503) RGD PMID:34096503 NCBI chr17:47,092,139...47,145,192
Ensembl chr17:47,092,207...47,144,063 		JBrowse link
G Ralb RAS like proto-oncogene B involved_in ISO
IEA		 UniProtKB:P11233 (PMID:34096503)
GO_REF:0000107		 RGD
Ensembl		 PMID:34096503 GO_REF:0000107 NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202 		JBrowse link
G Shkbp1 Sh3kbp1 binding protein 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(MGI:5700492|PMID:21830225)		 UniProt
RGD		 PMID:21830225 PMID:21873635 GO_REF:0000024 MGI:5700492, RGD:13792537 NCBI chr 1:82,636,797...82,650,330
Ensembl chr 1:82,636,797...82,650,375 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEP RGD PMID:8577724 RGD:1581110 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (MGI:3583038|PMID:15962011) RGD PMID:15962011 MGI:3583038 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh13 cadherin 13 involved_in ISO (PMID:17573778) RGD PMID:17573778 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in IMP
ISO
ISS		 PMID:15467833
(MGI:3057041|PMID:15467833)
GO_REF:0000024		 RGD
UniProt		 PMID:15467833 PMID:15467833 GO_REF:0000024 MGI:3057041, RGD:11059592 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Fer FER tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(PMID:21518868)		 UniProt
RGD		 PMID:21518868 GO_REF:0000024 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:24012640) RGD PMID:24012640 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mvb12a multivesicular body subunit 12A involved_in ISO
IBA		 (PMID:20654576)
PMID:21873635		 RGD PMID:20654576 PMID:21873635 RGD:13792537 NCBI chr16:18,252,227...18,257,111
Ensembl chr16:18,252,222...18,257,539 		JBrowse link
G Mvb12b multivesicular body subunit 12B involved_in ISO
IBA		 (PMID:20654576)
PMID:21873635		 RGD PMID:20654576 PMID:21873635 RGD:13792537 NCBI chr 3:17,034,002...17,192,658
Ensembl chr 3:17,034,003...17,193,202 		JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 involved_in ISO
IBA		 (PMID:27134172)
PMID:21873635		 RGD PMID:27134172 PMID:21873635 RGD:13792537 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927 		JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 involved_in IBA
ISO
ISS		 PMID:21873635
(PMID:18832597)
GO_REF:0000024		 RGD
UniProt		 PMID:18832597 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283 		JBrowse link
G Wdr54 WD repeat domain 54 involved_in ISO (PMID:30458214) RGD PMID:30458214 NCBI chr 4:115,654,968...115,677,979
Ensembl chr 4:115,654,968...115,661,562 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    cellular process 17330
      signal transduction 7035
        cell surface receptor signaling pathway 2786
          enzyme-linked receptor protein signaling pathway 1024
            transmembrane receptor protein tyrosine kinase signaling pathway 643
              ERBB signaling pathway 125
                epidermal growth factor receptor signaling pathway 112
                  ERBB2-EGFR signaling pathway 8
                  ERBB4-EGFR signaling pathway 0
                  epidermal growth factor receptor signaling pathway involved in heart process + 2
                  epidermal growth factor receptor signaling pathway involved in lung development 0
                  epidermal growth factor receptor signaling pathway via MAPK cascade 1
                  epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity + 1
                  epidermal growth factor signaling pathway involved in forebrain neuron fate commitment 0
                  gurken signaling pathway 0
                  negative regulation of epidermal growth factor receptor signaling pathway + 31
                  positive regulation of epidermal growth factor receptor signaling pathway + 27
                  regulation of epidermal growth factor receptor signaling pathway + 68
Path 2
Term Annotations click to browse term
  biological_process 19738
    biological regulation 13436
      regulation of biological process 13021
        signaling 7556
          signal transduction 7035
            cell surface receptor signaling pathway 2786
              enzyme-linked receptor protein signaling pathway 1024
                transmembrane receptor protein tyrosine kinase signaling pathway 643
                  ERBB signaling pathway 125
                    epidermal growth factor receptor signaling pathway 112
                      ERBB2-EGFR signaling pathway 8
                      ERBB4-EGFR signaling pathway 0
                      epidermal growth factor receptor signaling pathway involved in heart process + 2
                      epidermal growth factor receptor signaling pathway involved in lung development 0
                      epidermal growth factor receptor signaling pathway via MAPK cascade 1
                      epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity + 1
                      epidermal growth factor signaling pathway involved in forebrain neuron fate commitment 0
                      gurken signaling pathway 0
                      negative regulation of epidermal growth factor receptor signaling pathway + 31
                      positive regulation of epidermal growth factor receptor signaling pathway + 27
                      regulation of epidermal growth factor receptor signaling pathway + 68
paths to the root