ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) - Rat Genome Database

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Gene: ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Sus scrofa
Analyze
Symbol: ABL1
Name: ABL proto-oncogene 1, non-receptor tyrosine kinase (Ensembl:ABL proto-onco 1, non-receptor tyrosine kinase)
RGD ID: 14018415
Description: ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin filament polymerization (ortholog); activated T cell proliferation (ortholog); alpha-beta T cell differentiation (ortholog); PARTICIPATES IN p53 signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute myeloid leukemia (ortholog); FOUND IN dendrite (ortholog); growth cone (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: c-abl oncogene 1, non-receptor tyrosine kinase; tyrosine-protein kinase ABL1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1270,761,668 - 270,906,708 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11270,761,641 - 270,906,708 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21304,684,385 - 304,829,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
actin filament polymerization  (ISO)
activated T cell proliferation  (IEA,ISO)
adaptive immune response  (IEA)
alpha-beta T cell differentiation  (IEA,ISO)
associative learning  (ISO)
B cell proliferation  (IEA,ISO)
B cell proliferation involved in immune response  (IEA,ISO)
B cell receptor signaling pathway  (IEA,ISO)
B-1 B cell homeostasis  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cardiac muscle cell proliferation  (ISO)
cell communication  (IEA)
cell-cell adhesion  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to oxidative stress  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular senescence  (IEA,ISO)
cerebellum morphogenesis  (IEA,ISO)
circulatory system development  (IEA,ISO)
DN4 thymocyte differentiation  (IEA,ISO)
DNA conformation change  (IEA)
DNA damage response  (IEA)
endothelial cell migration  (IEA)
epidermal growth factor receptor signaling pathway  (IBA,IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
integrin-mediated signaling pathway  (IEA)
learning or memory  (ISO)
microspike assembly  (IEA,ISO)
myoblast proliferation  (ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of double-strand break repair via homologous recombination  (IEA)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of mitotic cell cycle  (IEA,ISO)
neural tube closure  (IEA,ISO)
neuroepithelial cell differentiation  (IEA,ISO)
neuromuscular process controlling balance  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuropilin signaling pathway  (IEA)
phagocytosis  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
podocyte apoptotic process  (ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of blood vessel branching  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of cellular process  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of dendrite development  (ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of establishment of T cell polarity  (IEA)
positive regulation of extracellular matrix organization  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
positive regulation of T cell migration  (IEA)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of vasoconstriction  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein autophosphorylation  (ISO)
protein localization to cytoplasmic microtubule plus-end  (IEA)
regulation of actin cytoskeleton organization  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of axon extension  (IEA)
regulation of Cdc42 protein signal transduction  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cellular component organization  (IEA)
regulation of cellular senescence  (IEA,ISO)
regulation of extracellular matrix organization  (IEA,ISO)
regulation of microtubule polymerization  (IEA)
regulation of modification of synaptic structure  (IEA)
regulation of T cell differentiation  (IEA)
response to endoplasmic reticulum stress  (ISO)
response to epinephrine  (ISO)
response to oxidative stress  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
signal transduction in response to DNA damage  (IEA)
signaling  (IEA)
spleen development  (IEA,ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
transitional one stage B cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ABL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1270,761,668 - 270,906,708 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11270,761,641 - 270,906,708 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21304,684,385 - 304,829,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389130,713,043 - 130,887,675 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9130,713,043 - 130,887,675 (+)EnsemblGRCh38hg38GRCh38
GRCh379133,588,430 - 133,763,062 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,579,089 - 132,752,883 (+)NCBINCBI36Build 36hg18NCBI36
Build 349130,619,260 - 130,792,614NCBI
Celera9104,127,800 - 104,301,349 (+)NCBICelera
Cytogenetic Map9q34.12NCBI
HuRef9103,075,969 - 103,249,725 (+)NCBIHuRef
CHM1_19133,738,310 - 133,911,675 (+)NCBICHM1_1
T2T-CHM13v2.09142,917,999 - 143,092,548 (+)NCBIT2T-CHM13v2.0
Abl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39231,578,256 - 31,697,105 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl231,578,388 - 31,694,239 (+)EnsemblGRCm39 Ensembl
GRCm38231,688,244 - 31,807,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl231,688,376 - 31,804,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv37231,544,076 - 31,659,747 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36231,581,991 - 31,626,236 (+)NCBIMGSCv36mm8
Celera231,389,208 - 31,506,940 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.86NCBI
Abl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,377,587 - 35,480,843 (+)NCBIGRCr8
mRatBN7.2314,979,853 - 15,083,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,979,853 - 15,083,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,053,160 - 18,156,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,638,164 - 26,741,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,885,255 - 24,988,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0310,041,820 - 10,145,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,041,826 - 10,144,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,410,661 - 9,448,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,401,182 - 15,504,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,804,594 - 10,907,162NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera39,728,420 - 9,830,777 (+)NCBICelera
Cytogenetic Map3p12NCBI
Abl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955513653,252 - 799,239 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955513652,048 - 799,182 (+)NCBIChiLan1.0ChiLan1.0
ABL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,467,889 - 8,639,598 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan198,470,232 - 8,640,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09101,834,189 - 102,005,811 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19130,482,852 - 130,652,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9130,484,333 - 130,652,941 (+)Ensemblpanpan1.1panPan2
ABL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1953,118,462 - 53,262,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl953,119,641 - 53,261,307 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha952,318,603 - 52,461,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0954,019,016 - 54,162,127 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl954,019,025 - 54,161,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,796,621 - 52,939,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0953,117,155 - 53,260,443 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,210,098 - 53,353,656 (-)NCBIUU_Cfam_GSD_1.0
Abl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947197,921,710 - 198,051,040 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648717,690,968 - 17,819,669 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648717,690,206 - 17,819,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1127,258,932 - 7,435,658 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl127,256,648 - 7,312,734 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660798,028,989 - 8,209,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247604,878,556 - 5,031,491 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247604,878,811 - 5,032,719 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABL1
5458 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 3 1
Low 9 4 3 5 2 20 2 2 3
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000006275   ⟹   ENSSSCP00000006113
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1270,857,854 - 270,906,708 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054304   ⟹   ENSSSCP00000053721
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1270,761,668 - 270,906,699 (+)Ensembl
RefSeq Acc Id: XM_005660524   ⟹   XP_005660581
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11270,761,641 - 270,906,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005660525   ⟹   XP_005660582
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11270,761,829 - 270,906,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005660526   ⟹   XP_005660583
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11270,857,967 - 270,906,708 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005660581   ⟸   XM_005660524
- Peptide Label: isoform X1
- UniProtKB: A0A287BB27 (UniProtKB/TrEMBL),   A0A8D1HDM8 (UniProtKB/TrEMBL),   A0A8D1P734 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005660582   ⟸   XM_005660525
- Peptide Label: isoform X1
- UniProtKB: A0A287BB27 (UniProtKB/TrEMBL),   A0A8D1HDM8 (UniProtKB/TrEMBL),   A0A8D1P734 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005660583   ⟸   XM_005660526
- Peptide Label: isoform X2
- UniProtKB: F1S0X4 (UniProtKB/TrEMBL),   A0A8D1H808 (UniProtKB/TrEMBL),   A0A8D1P5P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000053721   ⟸   ENSSSCT00000054304
RefSeq Acc Id: ENSSSCP00000006113   ⟸   ENSSSCT00000006275
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030059343 UniProtKB/TrEMBL
  ENSSSCG00035080466 UniProtKB/TrEMBL
  ENSSSCG00040044104 UniProtKB/TrEMBL
  ENSSSCG00045012693 UniProtKB/TrEMBL
  ENSSSCG00055001371 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006275 ENTREZGENE
  ENSSSCT00000006275.5 UniProtKB/TrEMBL
  ENSSSCT00000054304 ENTREZGENE
  ENSSSCT00000054304.2 UniProtKB/TrEMBL
  ENSSSCT00030082847.1 UniProtKB/TrEMBL
  ENSSSCT00030082890.1 UniProtKB/TrEMBL
  ENSSSCT00030082933.1 UniProtKB/TrEMBL
  ENSSSCT00035110246.1 UniProtKB/TrEMBL
  ENSSSCT00035110251.1 UniProtKB/TrEMBL
  ENSSSCT00035110261.1 UniProtKB/TrEMBL
  ENSSSCT00035110275.1 UniProtKB/TrEMBL
  ENSSSCT00040059115.1 UniProtKB/TrEMBL
  ENSSSCT00040059272.1 UniProtKB/TrEMBL
  ENSSSCT00045021605.1 UniProtKB/TrEMBL
  ENSSSCT00045021645.1 UniProtKB/TrEMBL
  ENSSSCT00045021673.1 UniProtKB/TrEMBL
  ENSSSCT00055002496.1 UniProtKB/TrEMBL
  ENSSSCT00055002532.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ABL_SH2 UniProtKB/TrEMBL
  F-actin_binding UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report ssc:100524544 UniProtKB/TrEMBL
NCBI Gene ABL1 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE ABL1 UniProtKB/TrEMBL
Pfam F_actin_bind UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FABD UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287BB27 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XJI1_PIG UniProtKB/TrEMBL
  A0A8D0XM46_PIG UniProtKB/TrEMBL
  A0A8D0XQD0_PIG UniProtKB/TrEMBL
  A0A8D1BCH2_PIG UniProtKB/TrEMBL
  A0A8D1BP32_PIG UniProtKB/TrEMBL
  A0A8D1D707_PIG UniProtKB/TrEMBL
  A0A8D1D711_PIG UniProtKB/TrEMBL
  A0A8D1EMZ3_PIG UniProtKB/TrEMBL
  A0A8D1EQ37_PIG UniProtKB/TrEMBL
  A0A8D1H7Y3_PIG UniProtKB/TrEMBL
  A0A8D1H808 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HDM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1P5P8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1P734 ENTREZGENE, UniProtKB/TrEMBL
  F1S0X4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:84984 ENTREZGENE