GAREM1 (GRB2 associated regulator of MAPK1 subtype 1) - Rat Genome Database

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Gene: GAREM1 (GRB2 associated regulator of MAPK1 subtype 1) Sus scrofa
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Symbol: GAREM1
Name: GRB2 associated regulator of MAPK1 subtype 1
RGD ID: 14264092
Description: ENCODES a protein that exhibits proline-rich region binding (inferred); INVOLVED IN multicellular organism growth (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH chromosome 18q deletion syndrome (ortholog); intellectual disability (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GAREM; GRB2 associated, regulator of MAPK1; GRB2-associated and regulator of MAPK protein; GRB2-associated and regulator of MAPK protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6116,100,372 - 116,325,133 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16116,100,371 - 116,324,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,838,673 - 109,028,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GAREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6116,100,372 - 116,325,133 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16116,100,371 - 116,324,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,838,673 - 109,028,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381832,263,522 - 32,470,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1832,124,877 - 32,470,882 (-)EnsemblGRCh38hg38GRCh38
GRCh371829,843,485 - 30,050,845 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361828,101,461 - 28,304,445 (-)NCBINCBI36Build 36hg18NCBI36
Build 341828,101,474 - 28,304,445NCBI
Celera1826,654,417 - 26,857,408 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1826,700,077 - 26,907,135 (-)NCBIHuRef
CHM1_11829,770,990 - 29,977,911 (-)NCBICHM1_1
T2T-CHM13v2.01832,453,815 - 32,661,186 (-)NCBIT2T-CHM13v2.0
Garem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391821,257,916 - 21,433,196 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1821,260,258 - 21,433,195 (-)EnsemblGRCm39 Ensembl
GRCm381821,127,342 - 21,300,139 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1821,127,201 - 21,300,138 (-)EnsemblGRCm38mm10GRCm38
MGSCv371821,285,843 - 21,458,640 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361821,270,211 - 21,443,148 (-)NCBIMGSCv36mm8
Celera1821,623,035 - 21,796,413 (-)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.87NCBI
Garem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,695,082 - 12,860,219 (-)NCBIGRCr8
mRatBN7.21812,420,169 - 12,585,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1812,423,882 - 12,585,345 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01814,982,604 - 15,007,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,224,514 - 12,284,188 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,224,514 - 12,284,188 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01814,769,102 - 14,791,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,944,256 - 12,946,270 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1812,415,517 - 12,519,188 (-)NCBICelera
Cytogenetic Map18p12NCBI
Garem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540219,469,649 - 19,663,654 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540219,469,652 - 19,663,654 (-)NCBIChiLan1.0ChiLan1.0
GAREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21749,639,460 - 49,847,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11835,332,057 - 35,540,119 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01825,470,702 - 25,678,146 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11829,065,053 - 29,272,225 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1829,065,053 - 29,272,231 (-)Ensemblpanpan1.1panPan2
GAREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,158,005 - 57,423,643 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,295,070 - 57,419,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha756,654,442 - 56,856,713 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0757,196,399 - 57,404,576 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl757,195,979 - 57,400,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1756,881,075 - 57,082,118 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0756,898,894 - 57,100,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0757,195,790 - 57,397,330 (+)NCBIUU_Cfam_GSD_1.0
Garem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494452,926,545 - 53,066,880 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936682947,487 - 1,068,482 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936682947,420 - 1,068,468 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11848,287,589 - 48,483,135 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1848,287,579 - 48,483,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605022,837,054 - 23,033,716 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Garem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624770500,641 - 728,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624770501,113 - 727,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GAREM1
4985 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000004131   ⟹   ENSSSCP00000004038
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6116,100,372 - 116,325,133 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000078932   ⟹   ENSSSCP00000067634
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6116,100,370 - 116,325,331 (-)Ensembl
RefSeq Acc Id: XM_003482054   ⟹   XP_003482102
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16116,100,371 - 116,324,853 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021096217   ⟹   XP_020951876
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16116,100,371 - 116,324,803 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021096218   ⟹   XP_020951877
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16116,100,371 - 116,321,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021096219   ⟹   XP_020951878
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16116,100,371 - 116,183,744 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003482102   ⟸   XM_003482054
- Peptide Label: isoform X2
- UniProtKB: A0A480WKU6 (UniProtKB/TrEMBL),   A0A4X1VK39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951876   ⟸   XM_021096217
- Peptide Label: isoform X1
- UniProtKB: F1SAL5 (UniProtKB/TrEMBL),   A0A8D1IDJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951877   ⟸   XM_021096218
- Peptide Label: isoform X3
- UniProtKB: A0A8D1IDJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951878   ⟸   XM_021096219
- Peptide Label: isoform X4
- UniProtKB: A0A8D0MM26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000067634   ⟸   ENSSSCT00000078932
Ensembl Acc Id: ENSSSCP00000004038   ⟸   ENSSSCT00000004131
Protein Domains
CABIT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003731 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015011375 UniProtKB/TrEMBL
  ENSSSCG00025043195 UniProtKB/TrEMBL
  ENSSSCG00030025214 UniProtKB/TrEMBL
  ENSSSCG00035011329 UniProtKB/TrEMBL
  ENSSSCG00040063708 UniProtKB/TrEMBL
  ENSSSCG00045025264 UniProtKB/TrEMBL
  ENSSSCG00055002693 UniProtKB/TrEMBL
  ENSSSCG00060058806 UniProtKB/TrEMBL
  ENSSSCG00065044175 UniProtKB/TrEMBL
  ENSSSCG00070024773 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004131 ENTREZGENE
  ENSSSCT00000004131.5 UniProtKB/TrEMBL
  ENSSSCT00015014932.1 UniProtKB/TrEMBL
  ENSSSCT00015015021.1 UniProtKB/TrEMBL
  ENSSSCT00025058531.1 UniProtKB/TrEMBL
  ENSSSCT00025058638.1 UniProtKB/TrEMBL
  ENSSSCT00030035183.1 UniProtKB/TrEMBL
  ENSSSCT00035014205.1 UniProtKB/TrEMBL
  ENSSSCT00035014212.1 UniProtKB/TrEMBL
  ENSSSCT00040086941.1 UniProtKB/TrEMBL
  ENSSSCT00045043045.1 UniProtKB/TrEMBL
  ENSSSCT00045043145.1 UniProtKB/TrEMBL
  ENSSSCT00055005140.1 UniProtKB/TrEMBL
  ENSSSCT00055005150.1 UniProtKB/TrEMBL
  ENSSSCT00060080197.1 UniProtKB/TrEMBL
  ENSSSCT00065060413.1 UniProtKB/TrEMBL
  ENSSSCT00070049513.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
InterPro CABIT_dom UniProtKB/TrEMBL
  GAREM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
NCBI Gene GAREM1 ENTREZGENE
PANTHER GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN 1 UniProtKB/TrEMBL
  GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam CABIT UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
UniProt A0A480WKU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VK39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0MM26 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IDJ3 ENTREZGENE, UniProtKB/TrEMBL
  F1SAL5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88349 ENTREZGENE