EPHA6 (EPH receptor A6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: EPHA6 (EPH receptor A6) Sus scrofa
Analyze
Symbol: EPHA6
Name: EPH receptor A6
RGD ID: 13876570
Description: ENCODES a protein that exhibits ATP binding (inferred); ephrin receptor activity (inferred); protein tyrosine kinase activity (inferred); INVOLVED IN axon guidance (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); ephrin receptor signaling pathway (inferred); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Bardet-Biedl syndrome 3 (ortholog); genetic disease (ortholog); FOUND IN dendrite (inferred); membrane (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ephrin type-A receptor 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113162,568,835 - 163,445,722 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213173,570,910 - 173,735,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
dendrite  (IBA,IEA)
membrane  (IEA)
nucleoplasm  (IEA)
plasma membrane  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EPHA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113162,568,835 - 163,445,722 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213173,570,910 - 173,735,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38396,814,594 - 97,761,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl396,814,581 - 97,761,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37396,533,438 - 97,480,376 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36398,016,115 - 98,950,476 (+)NCBINCBI36Build 36hg18NCBI36
Celera394,916,109 - 95,857,365 (+)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef393,902,924 - 94,837,692 (+)NCBIHuRef
CHM1_1396,496,480 - 97,430,819 (+)NCBICHM1_1
T2T-CHM13v2.0399,518,416 - 100,468,755 (+)NCBIT2T-CHM13v2.0
Epha6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391659,473,424 - 60,431,196 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1659,473,846 - 60,425,894 (-)EnsemblGRCm39 Ensembl
GRCm381659,641,433 - 60,610,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1659,653,483 - 60,605,531 (-)EnsemblGRCm38mm10GRCm38
MGSCv371659,653,309 - 60,605,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361659,595,739 - 60,547,503 (-)NCBIMGSCv36mm8
Celera1660,004,715 - 60,923,397 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1634.83NCBI
Epha6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81153,226,784 - 54,178,120 (+)NCBIGRCr8
mRatBN7.21139,757,501 - 40,708,901 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1139,757,181 - 40,698,311 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01141,867,607 - 42,843,800 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,259,761 - 42,843,865 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01145,066,461 - 46,035,688 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41140,551,554 - 41,458,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11140,597,889 - 41,024,933 (+)NCBI
Celera1139,606,772 - 40,545,970 (+)NCBICelera
Cytogenetic Map11q12NCBI
Epha6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955407400,745 - 1,220,538 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955407398,415 - 1,220,542 (-)NCBIChiLan1.0ChiLan1.0
EPHA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2294,719,146 - 95,674,832 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1394,723,932 - 95,679,616 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0393,881,686 - 94,819,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13100,562,841 - 101,504,222 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3100,734,791 - 101,503,805 (+)Ensemblpanpan1.1panPan2
EPHA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1333,990,346 - 4,786,070 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl334,517,039 - 4,684,336 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha334,093,700 - 4,967,547 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0334,023,454 - 4,896,341 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1333,901,331 - 4,772,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0333,961,065 - 4,833,214 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0334,235,497 - 5,107,565 (+)NCBIUU_Cfam_GSD_1.0
Epha6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602152,451,572 - 153,234,891 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366662,282,000 - 3,061,944 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366662,280,811 - 3,063,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,960,714 - 83,914,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604182,679,583 - 83,623,162 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247899,281,370 - 10,209,495 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247899,279,440 - 10,211,840 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EPHA6
19288 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system renal system reproductive system
High
Medium 5
Low 3 18 2 1
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000047734   ⟹   ENSSSCP00000032586
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000049582   ⟹   ENSSSCP00000032821
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)Ensembl
RefSeq Acc Id: XM_021070701   ⟹   XP_020926360
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070702   ⟹   XP_020926361
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,717 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070703   ⟹   XP_020926362
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070704   ⟹   XP_020926363
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,722 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070706   ⟹   XP_020926365
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,718 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070707   ⟹   XP_020926366
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,443,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070708   ⟹   XP_020926367
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,352,874 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070709   ⟹   XP_020926368
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,709,646 - 163,445,717 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070710   ⟹   XP_020926369
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070711   ⟹   XP_020926370
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,075,694 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070712   ⟹   XP_020926371
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,718 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002337952
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113163,067,971 - 163,445,721 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002337953
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,919,216 - 163,445,721 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020926363   ⟸   XM_021070704
- Peptide Label: isoform X4
- UniProtKB: A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926369   ⟸   XM_021070710
- Peptide Label: isoform X8
- UniProtKB: A0A8D1NTJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926362   ⟸   XM_021070703
- Peptide Label: isoform X3
- UniProtKB: A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926360   ⟸   XM_021070701
- Peptide Label: isoform X1
- UniProtKB: A0A4X1URF5 (UniProtKB/TrEMBL),   A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926371   ⟸   XM_021070712
- Peptide Label: isoform X10
- UniProtKB: A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926365   ⟸   XM_021070706
- Peptide Label: isoform X5
- UniProtKB: A0A8D0LJU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926361   ⟸   XM_021070702
- Peptide Label: isoform X2
- UniProtKB: A0A286ZM00 (UniProtKB/TrEMBL),   A0A4X1UL82 (UniProtKB/TrEMBL),   A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926366   ⟸   XM_021070707
- Peptide Label: isoform X6
- UniProtKB: A0A8D0LJU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926367   ⟸   XM_021070708
- Peptide Label: isoform X6
- UniProtKB: A0A8D0LJU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926370   ⟸   XM_021070711
- Peptide Label: isoform X9
- UniProtKB: A0A8D1ZBF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926368   ⟸   XM_021070709
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSSSCP00000032821   ⟸   ENSSSCT00000049582
RefSeq Acc Id: ENSSSCP00000032586   ⟸   ENSSSCT00000047734
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033898 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005014648 UniProtKB/TrEMBL
  ENSSSCG00025060197 UniProtKB/TrEMBL
  ENSSSCG00030054243 UniProtKB/TrEMBL
  ENSSSCG00040022638 UniProtKB/TrEMBL
  ENSSSCG00050075488 UniProtKB/TrEMBL
  ENSSSCG00065058289 UniProtKB/TrEMBL
  ENSSSCG00070018692 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000047734 ENTREZGENE
  ENSSSCT00000047734.2 UniProtKB/TrEMBL
  ENSSSCT00000049582.2 UniProtKB/TrEMBL
  ENSSSCT00005023306.1 UniProtKB/TrEMBL
  ENSSSCT00025082411.1 UniProtKB/TrEMBL
  ENSSSCT00025082694.1 UniProtKB/TrEMBL
  ENSSSCT00030075608.1 UniProtKB/TrEMBL
  ENSSSCT00030075622.1 UniProtKB/TrEMBL
  ENSSSCT00040030368.1 UniProtKB/TrEMBL
  ENSSSCT00050103532.1 UniProtKB/TrEMBL
  ENSSSCT00065079775.1 UniProtKB/TrEMBL
  ENSSSCT00070036854.1 UniProtKB/TrEMBL
  ENSSSCT00070036863.1 UniProtKB/TrEMBL
  ENSSSCT00070036873.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro EPH-A6_SAM UniProtKB/TrEMBL
  Eph_TM UniProtKB/TrEMBL
  EphA6_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
NCBI Gene EPHA6 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 6 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A286ZM00 ENTREZGENE, UniProtKB/TrEMBL
  A0A286ZMY5_PIG UniProtKB/TrEMBL
  A0A4X1UL82 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UL92_PIG UniProtKB/TrEMBL
  A0A4X1URF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0LJU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1K6G3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1NTJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ZBF5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:108655 ENTREZGENE