EPHA6 (EPH receptor A6) - Rat Genome Database

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Gene: EPHA6 (EPH receptor A6) Sus scrofa
Analyze
Symbol: EPHA6
Name: EPH receptor A6
RGD ID: 13876570
Description: ENCODES a protein that exhibits ATP binding (inferred); ephrin receptor activity (inferred); kinase activity (inferred); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (inferred); ephrin receptor signaling pathway (inferred); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Bardet-Biedl syndrome 3 (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ephrin type-A receptor 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113162,568,835 - 163,445,722 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213173,570,910 - 173,735,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EPHA6PigBardet-Biedl syndrome 3  ISORGD:16055468554872ClinVar Annotator: match by term: Bardet-Biedl syndrome 3ClinVarPMID:15258860|PMID:19858128|PMID:20142850|PMID:22334370|PMID:27486776|PMID:28492532|PMID:31736247


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EPHA6Pigaxon guidance involved_inIBAMGI:104770|MGI:109378|MGI:1096337|MGI:95276|MGI:98277|MGI:99611|PANTHER:PTN000699977150520179 GO_CentralGO_REF:0000033
EPHA6Pigcell surface receptor protein tyrosine kinase signaling pathway involved_inIEAInterPro:IPR001426150520179 InterProGO_REF:0000002
EPHA6Pigephrin receptor signaling pathway involved_inIEAGO:0005003150520179 GOCGO_REF:0000108
EPHA6Pigephrin receptor signaling pathway involved_inIBAMGI:109378|MGI:1096337|MGI:95276|MGI:99611|MGI:99612|PANTHER:PTN000699977|RGD:620831|UniProtKB:A0A8M1QKD8|UniProtKB:P29320|UniProtKB:P54753|UniProtKB:P54762|UniProtKB:P54764|UniProtKB:Q15375150520179 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EPHA6Pigdendrite is_active_inIBAMGI:98277|MGI:99611|PANTHER:PTN000699977|RGD:1560587|RGD:1564232|RGD:70957|UniProtKB:P54756150520179 GO_CentralGO_REF:0000033
EPHA6Pigmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
EPHA6Pigmembrane located_inIEAInterPro:IPR001426150520179 InterProGO_REF:0000002
EPHA6Pigmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
EPHA6Pigplasma membrane is_active_inIBAMGI:109378|MGI:98277|MGI:99611|PANTHER:PTN001230543|RGD:1560587|RGD:620831|RGD:70957|UniProtKB:P29320|UniProtKB:P29323|UniProtKB:P54753|UniProtKB:P54756|UniProtKB:P54762|UniProtKB:Q15375150520179 GO_CentralGO_REF:0000033

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EPHA6PigATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
EPHA6PigATP binding enablesIEAInterPro:IPR000719|InterPro:IPR001426|InterPro:IPR017441150520179 InterProGO_REF:0000002
EPHA6PigATP binding enablesIEAUniRule:UR001503341150520179 UniProtGO_REF:0000104
EPHA6Pigephrin receptor activity enablesIEAInterPro:IPR001426150520179 InterProGO_REF:0000002
EPHA6Pigkinase activity enablesIEAUniProtKB-KW:KW-0418150520179 UniProtGO_REF:0000043
EPHA6Pignucleotide binding enablesIEAUniRule:UR001503341150520179 UniProtGO_REF:0000104
EPHA6Pignucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
EPHA6Pigprotein binding enablesISOUniProtKB:P293179068941 PMID:33961781IntActPMID:33961781
EPHA6Pigprotein binding enablesISOUniProtKB:Q047719068941 PMID:31483918IntActPMID:31483918
EPHA6Pigprotein binding enablesISOUniProtKB:P29317|UniProtKB:P547609068941 PMID:35384245IntActPMID:35384245
EPHA6Pigprotein kinase activity enablesIEAInterPro:IPR000719|InterPro:IPR001245|InterPro:IPR008266150520179 InterProGO_REF:0000002
EPHA6Pigprotein tyrosine kinase activity enablesIEAInterPro:IPR020635150520179 InterProGO_REF:0000002
EPHA6Pigprotein tyrosine kinase activity enablesIEAUniProtKB-KW:KW-0829150520179 UniProtGO_REF:0000043
EPHA6Pigtransmembrane receptor protein tyrosine kinase activity enablesIEAEC:2.7.10.1150520179 UniProtGO_REF:0000003
EPHA6Pigtransmembrane-ephrin receptor activity enablesIBAMGI:98277|MGI:99611|PANTHER:PTN000699977|UniProtKB:P54762|UniProtKB:Q5JZY3150520179 GO_CentralGO_REF:0000033
1 to 15 of 15 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EPHA6Pigephrin - ephrin receptor bidirectional signaling axis  ISORGD:16055469068941 PIDPID:200142
PMID:22301074   PMID:30032202  



EPHA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113162,568,835 - 163,445,722 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213173,570,910 - 173,735,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38396,814,594 - 97,761,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl396,814,581 - 97,761,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37396,533,438 - 97,480,376 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36398,016,115 - 98,950,476 (+)NCBINCBI36Build 36hg18NCBI36
Celera394,916,109 - 95,857,365 (+)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef393,902,924 - 94,837,692 (+)NCBIHuRef
CHM1_1396,496,480 - 97,430,819 (+)NCBICHM1_1
T2T-CHM13v2.0399,518,416 - 100,468,755 (+)NCBIT2T-CHM13v2.0
Epha6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391659,473,424 - 60,431,196 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1659,473,846 - 60,425,894 (-)EnsemblGRCm39 Ensembl
GRCm381659,641,433 - 60,610,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1659,653,483 - 60,605,531 (-)EnsemblGRCm38mm10GRCm38
MGSCv371659,653,309 - 60,605,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361659,595,739 - 60,547,503 (-)NCBIMGSCv36mm8
Celera1660,004,715 - 60,923,397 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1634.83NCBI
Epha6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81153,226,784 - 54,178,120 (+)NCBIGRCr8
mRatBN7.21139,757,501 - 40,708,901 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1139,757,181 - 40,698,311 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01141,867,607 - 42,843,800 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,259,761 - 42,843,865 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01145,066,461 - 46,035,688 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41140,551,554 - 41,458,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11140,597,889 - 41,024,933 (+)NCBI
Celera1139,606,772 - 40,545,970 (+)NCBICelera
Cytogenetic Map11q12NCBI
Epha6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955407400,745 - 1,220,538 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955407398,415 - 1,220,542 (-)NCBIChiLan1.0ChiLan1.0
EPHA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2294,719,146 - 95,674,832 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1394,723,932 - 95,679,616 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0393,881,686 - 94,819,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13100,562,841 - 101,504,222 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3100,734,791 - 101,503,805 (+)Ensemblpanpan1.1panPan2
EPHA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1333,990,346 - 4,786,070 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl334,517,039 - 4,684,336 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha334,093,700 - 4,967,547 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0334,023,454 - 4,896,341 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1333,901,331 - 4,772,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0333,961,065 - 4,833,214 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0334,235,497 - 5,107,565 (+)NCBIUU_Cfam_GSD_1.0
Epha6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602152,451,572 - 153,234,891 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366662,282,000 - 3,061,944 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366662,280,811 - 3,063,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,960,714 - 83,914,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604182,679,583 - 83,623,162 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247899,281,370 - 10,209,495 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247899,279,440 - 10,211,840 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in EPHA6
19150 total Variants



alimentary part of gastrointestinal system
ectoderm
endocrine system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
3 23 3 4 1 23 3 4



Ensembl Acc Id: ENSSSCT00000047734   ⟹   ENSSSCP00000032586
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000049582   ⟹   ENSSSCP00000032821
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13162,569,479 - 163,443,646 (-)Ensembl
RefSeq Acc Id: XM_021070701   ⟹   XP_020926360
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070702   ⟹   XP_020926361
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,717 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070703   ⟹   XP_020926362
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070704   ⟹   XP_020926363
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,722 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070706   ⟹   XP_020926365
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,718 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070707   ⟹   XP_020926366
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,443,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070708   ⟹   XP_020926367
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,352,874 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070709   ⟹   XP_020926368
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,709,646 - 163,445,717 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070710   ⟹   XP_020926369
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070711   ⟹   XP_020926370
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,075,694 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070712   ⟹   XP_020926371
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,568,835 - 163,445,718 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002337952
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113163,067,971 - 163,445,721 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002337953
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113162,919,216 - 163,445,721 (-)NCBI
Sequence:
1 to 5 of 13 rows
1 to 5 of 13 rows
RefSeq Acc Id: XP_020926363   ⟸   XM_021070704
- Peptide Label: isoform X4
- UniProtKB: A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926369   ⟸   XM_021070710
- Peptide Label: isoform X8
- UniProtKB: A0A8D1NTJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926362   ⟸   XM_021070703
- Peptide Label: isoform X3
- UniProtKB: A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926360   ⟸   XM_021070701
- Peptide Label: isoform X1
- UniProtKB: A0A4X1URF5 (UniProtKB/TrEMBL),   A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926371   ⟸   XM_021070712
- Peptide Label: isoform X10
- UniProtKB: A0A8D1K6G3 (UniProtKB/TrEMBL)
- Sequence:
Eph LBD   Fibronectin type-III   Protein kinase   SAM



1 to 40 of 85 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000033898 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025060197 UniProtKB/TrEMBL
  ENSSSCG00030054243 UniProtKB/TrEMBL
  ENSSSCG00040022638 UniProtKB/TrEMBL
  ENSSSCG00050075488 UniProtKB/TrEMBL
  ENSSSCG00065058289 UniProtKB/TrEMBL
  ENSSSCG00070018692 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000047734 ENTREZGENE
  ENSSSCT00000047734.2 UniProtKB/TrEMBL
  ENSSSCT00000049582.2 UniProtKB/TrEMBL
  ENSSSCT00025082411.1 UniProtKB/TrEMBL
  ENSSSCT00025082694.1 UniProtKB/TrEMBL
  ENSSSCT00030075608.1 UniProtKB/TrEMBL
  ENSSSCT00030075622.1 UniProtKB/TrEMBL
  ENSSSCT00040030368.1 UniProtKB/TrEMBL
  ENSSSCT00050103532.1 UniProtKB/TrEMBL
  ENSSSCT00065079775.1 UniProtKB/TrEMBL
  ENSSSCT00070036854.1 UniProtKB/TrEMBL
  ENSSSCT00070036863.1 UniProtKB/TrEMBL
  ENSSSCT00070036873.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro EPH-A6_SAM UniProtKB/TrEMBL
  Eph_TM UniProtKB/TrEMBL
  EphA6_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  Ephrin_rcpt_TKs UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
1 to 40 of 85 rows