Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Epha6 | Mouse | 4-hydroperoxycyclophosphamide | decreases expression | EXP | | 6480464 | perfosfamide results in decreased expression of EPHA6 mRNA | CTD | PMID:19429390 | Epha6 | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of EPHA6 mRNA | CTD | PMID:24780913 | Epha6 | Mouse | 6-propyl-2-thiouracil | increases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of EPHA6 mRNA | CTD | PMID:36843608 | Epha6 | Mouse | acrylamide | decreases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of EPHA6 mRNA | CTD | PMID:32763439 | Epha6 | Mouse | aflatoxin B1 | decreases methylation | ISO | EPHA6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of EPHA6 gene and Aflatoxin B1 results in decreased methylation of EPHA6 intron | CTD | PMID:27153756 and PMID:30157460 | Epha6 | Mouse | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of EPHA6 mRNA | CTD | PMID:36189433 | Epha6 | Mouse | all-trans-retinoic acid | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EPHA6 mRNA | CTD | PMID:36189433 | Epha6 | Mouse | allethrin | multiple interactions | ISO | Epha6 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EPHA6 protein | CTD | PMID:34896426 | Epha6 | Mouse | aristolochic acid A | decreases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of EPHA6 mRNA | CTD | PMID:33212167 | Epha6 | Mouse | arsenite(3-) | increases expression | EXP | | 6480464 | arsenite results in increased expression of EPHA6 mRNA | CTD | PMID:33053406 | Epha6 | Mouse | atrazine | affects methylation | ISO | Epha6 (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of EPHA6 gene | CTD | PMID:28931070 | Epha6 | Mouse | benzo[a]pyrene | increases methylation | ISO | EPHA6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of EPHA6 exon and Benzo(a)pyrene results in increased methylation of EPHA6 promoter | CTD | PMID:27901495 | Epha6 | Mouse | bisphenol A | decreases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of EPHA6 mRNA | CTD | PMID:25181051 more ... | Epha6 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EPHA6 mRNA | CTD | PMID:35598803 | Epha6 | Mouse | carbamazepine | affects expression | ISO | EPHA6 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of EPHA6 mRNA | CTD | PMID:25979313 | Epha6 | Mouse | CGP 52608 | multiple interactions | ISO | EPHA6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EPHA6 gene] | CTD | PMID:28238834 | Epha6 | Mouse | copper atom | increases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of EPHA6 mRNA | CTD | PMID:26033743 | Epha6 | Mouse | copper(0) | increases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of EPHA6 mRNA | CTD | PMID:26033743 | Epha6 | Mouse | copper(II) sulfate | decreases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of EPHA6 mRNA | CTD | PMID:19549813 | Epha6 | Mouse | Cuprizon | decreases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Cuprizone results in decreased expression of EPHA6 mRNA | CTD | PMID:26577399 | Epha6 | Mouse | cyhalothrin | multiple interactions | ISO | Epha6 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EPHA6 protein | CTD | PMID:34896426 | Epha6 | Mouse | cypermethrin | multiple interactions | ISO | Epha6 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EPHA6 protein | CTD | PMID:34896426 | Epha6 | Mouse | dorsomorphin | multiple interactions | ISO | EPHA6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA6 mRNA | CTD | PMID:27188386 | Epha6 | Mouse | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of EPHA6 mRNA | CTD | PMID:35436446 | Epha6 | Mouse | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of EPHA6 mRNA | CTD | PMID:29018328 | Epha6 | Mouse | fenvalerate | multiple interactions | ISO | Epha6 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EPHA6 protein | CTD | PMID:34896426 | Epha6 | Mouse | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of EPHA6 mRNA | CTD | PMID:21810550 | Epha6 | Mouse | glyphosate | affects methylation | ISO | Epha6 (Rattus norvegicus) | 6480464 | Glyphosate affects the methylation of EPHA6 gene | CTD | PMID:35440735 | Epha6 | Mouse | iron dichloride | increases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | ferrous chloride results in increased expression of EPHA6 mRNA | CTD | PMID:35984750 | Epha6 | Mouse | lipopolysaccharide | decreases expression | EXP | | 6480464 | Lipopolysaccharides results in decreased expression of EPHA6 mRNA | CTD | PMID:12057914 | Epha6 | Mouse | methoxychlor | affects methylation | ISO | Epha6 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of EPHA6 gene | CTD | PMID:35440735 | Epha6 | Mouse | mono(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EPHA6 mRNA | CTD | PMID:36189433 | Epha6 | Mouse | paracetamol | affects expression | ISO | EPHA6 (Homo sapiens) | 6480464 | Acetaminophen affects the expression of EPHA6 mRNA | CTD | PMID:26690555 | Epha6 | Mouse | permethrin | increases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | Permethrin results in increased expression of EPHA6 mRNA | CTD | PMID:37047231 | Epha6 | Mouse | progesterone | decreases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Progesterone results in decreased expression of EPHA6 mRNA | CTD | PMID:21770760 | Epha6 | Mouse | pyrethrins | decreases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Pyrethrins results in decreased expression of EPHA6 protein | CTD | PMID:34896426 | Epha6 | Mouse | SB 431542 | multiple interactions | ISO | EPHA6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA6 mRNA | CTD | PMID:27188386 | Epha6 | Mouse | sodium arsenite | increases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of EPHA6 mRNA | CTD | PMID:38568856 | Epha6 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of EPHA6 promoter | CTD | PMID:35295148 | Epha6 | Mouse | triclosan | increases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | Triclosan results in increased expression of EPHA6 mRNA | CTD | PMID:30510588 | Epha6 | Mouse | valproic acid | decreases methylation | ISO | EPHA6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of EPHA6 gene | CTD | PMID:29154799 | Epha6 | Mouse | valproic acid | increases expression | ISO | EPHA6 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EPHA6 mRNA | CTD | PMID:23179753 more ... | Epha6 | Mouse | valproic acid | multiple interactions | ISO | EPHA6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA6 mRNA | CTD | PMID:27188386 | Epha6 | Mouse | valproic acid | affects splicing | ISO | Epha6 (Rattus norvegicus) | 6480464 | Valproic Acid affects the splicing of EPHA6 mRNA | CTD | PMID:29427782 | Epha6 | Mouse | valproic acid | decreases expression | ISO | Epha6 (Rattus norvegicus) | 6480464 | Valproic Acid results in decreased expression of EPHA6 mRNA | CTD | PMID:29427782 | Epha6 | Mouse | vinclozolin | increases methylation | ISO | Epha6 (Rattus norvegicus) | 6480464 | vinclozolin results in increased methylation of EPHA6 gene | CTD | PMID:31079544 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
Imported Annotations - PID (archival)
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
Molecular Function
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 2. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 3. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 4. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8892754 | PMID:9267020 | PMID:10349636 | PMID:10495276 | PMID:10559410 | PMID:10774725 | PMID:11042159 | PMID:11076861 | PMID:11114734 | PMID:11217851 | PMID:11222144 | PMID:11439183 |
| PMID:12124402 | PMID:12217323 | PMID:12466851 | PMID:12477932 | PMID:12528186 | PMID:12684176 | PMID:12702772 | PMID:15996548 | PMID:16141072 | PMID:16141073 | PMID:16446123 | PMID:16547242 |
| PMID:16602821 | PMID:16910173 | PMID:16919269 | PMID:17039519 | PMID:17145500 | PMID:17304517 | PMID:18287559 | PMID:18450376 | PMID:18799693 | PMID:19542359 | PMID:19769959 | PMID:20112066 |
| PMID:20308569 | PMID:20615956 | PMID:21267068 | PMID:21490208 | PMID:21677750 | PMID:21873635 | PMID:22065784 | PMID:24194600 | PMID:24360543 | PMID:24550361 | PMID:24945320 | PMID:24952961 |
| PMID:25073978 | PMID:25367067 | PMID:25480914 | PMID:26830346 | PMID:26941654 | PMID:27402841 | PMID:27626380 | PMID:28197551 | PMID:28558017 | PMID:31666685 | PMID:32492419 | PMID:34321999 |
| PMID:38355793 |
Genomics
Comparative Map Data
| Epha6 (Mus musculus - house mouse) |
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| EPHA6 (Homo sapiens - human) |
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| Epha6 (Rattus norvegicus - Norway rat) |
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| Epha6 (Chinchilla lanigera - long-tailed chinchilla) |
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| EPHA6 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| EPHA6 (Canis lupus familiaris - dog) |
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| Epha6 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| EPHA6 (Sus scrofa - pig) |
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| EPHA6 (Chlorocebus sabaeus - green monkey) |
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| Epha6 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Epha6
35911 total Variants 
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