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Gene: EPHB4 (EPH receptor B4) Homo sapiens
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Symbol: EPHB4
Name: EPH receptor B4
Description: Exhibits ephrin receptor activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; ephrin receptor signaling pathway; and protein autophosphorylation. Localizes to the integral component of plasma membrane. Implicated in hereditary lymphedema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMAVM2; ephrin receptor EphB4; ephrin type-B receptor 4; hepatoma transmembrane kinase; HFASD; HTK; LMPHM7; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11
Orthologs:
Mus musculus (house mouse) : Ephb4 (Eph receptor B4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ephb4 (EPH receptor B4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephb4 (EPH receptor B4)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHB4 (EPH receptor B4)
Canis lupus familiaris (dog) : EPHB4 (EPH receptor B4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephb4 (EPH receptor B4)
Sus scrofa (pig) : EPHB4 (EPH receptor B4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,802,565 - 100,827,523 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,400,187 - 100,425,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,238,123 - 100,263,079 (-)NCBINCBI36hg18NCBI36
Build 347100,044,837 - 100,069,794NCBI
Celera795,130,741 - 95,155,701 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,030,927 - 95,055,371 (-)NCBIHuRef
CHM1_17100,330,777 - 100,355,761 (-)NCBICHM1_1
CRA_TCAGchr7v2799,759,792 - 99,784,748 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EPHB4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353692
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.