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Gene: NRG3 (neuregulin 3) Sus scrofa

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Symbol:

NRG3

Name:

neuregulin 3

RGD ID:

14277284

Description:

ENCODES a protein that exhibits chemorepellent activity (inferred); growth factor activity (inferred); receptor ligand activity (inferred); INVOLVED IN chemorepulsion involved in interneuron migration from the subpallium to the cortex (ortholog); intracellular signal transduction (ortholog); mammary gland development (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog); schizophrenia (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pro-neuregulin-3, membrane-bound isoform

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NRG3 (neuregulin 3)	HGNC	NCBI
Mus musculus (house mouse):	Nrg3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Nrg3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nrg3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NRG3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NRG3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101957192 (pro-neuregulin-3, membrane-bound isoform)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NRG3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nrg3 (neuregulin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	83,317,019 - 84,402,943 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	83,316,962 - 84,405,347 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	90,842,758 - 91,108,804 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hirschsprung's disease (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemorepulsion involved in interneuron migration from the subpallium to the cortex (IEA,ISO)

ERBB4 signaling pathway (IBA,IEA)

ERBB4-ERBB4 signaling pathway (IEA)

intracellular signal transduction (IBA,IEA,ISO)

mammary gland development (IEA,ISO)

mammary placode formation (IEA,ISO)

modulation of chemical synaptic transmission (IEA)

negative chemotaxis (IEA)

negative regulation of neuron migration (IEA,ISO)

nervous system development (IEA)

pattern specification process (IEA,ISO)

signal transduction (IEA)

synapse assembly (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IEA)

glutamatergic synapse (IEA,ISO)

membrane (IEA)

plasma membrane (IEA)

synapse (IEA,ISO)

Molecular Function

chemorepellent activity (IBA,IEA)

growth factor activity (IEA)

protein binding (ISO)

receptor ligand activity (IEA)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

NRG3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	83,317,019 - 84,402,943 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	83,316,962 - 84,405,347 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	90,842,758 - 91,108,804 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NRG3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	81,875,194 - 82,987,179 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	81,875,194 - 82,987,179 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	83,634,950 - 84,746,935 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	83,625,077 - 84,735,341 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	77,630,757 - 78,742,147 (+)	NCBI		Celera
Cytogenetic Map	10	q23.1	NCBI
HuRef	10	77,483,814 - 78,594,633 (+)	NCBI		HuRef
CHM1_1	10	83,917,602 - 85,028,760 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	82,749,017 - 83,860,555 (+)	NCBI		T2T-CHM13v2.0

Nrg3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	38,086,093 - 39,195,045 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	38,090,909 - 39,195,045 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	38,365,102 - 39,473,235 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	38,368,952 - 39,473,088 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	39,182,137 - 40,286,376 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	37,282,204 - 38,384,967 (-)	NCBI		MGSCv36	mm8
Celera	14	34,560,237 - 35,661,300 (-)	NCBI		Celera
Cytogenetic Map	14	B	NCBI

Nrg3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	14,256,540 - 15,374,107 (-)	NCBI		GRCr8
mRatBN7.2	16	14,229,270 - 15,352,505 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	14,235,157 - 15,352,368 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	16	15,763,031 - 16,932,208 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	15,764,632 - 15,798,974 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	15,661,430 - 16,817,319 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	14,679,903 - 15,817,157 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	14,466,369 - 15,581,462 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Nrg3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955510	1,615,316 - 2,618,617 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955510	1,615,316 - 2,620,031 (+)	NCBI	ChiLan1.0	ChiLan1.0

NRG3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	93,833,755 - 94,981,643 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	93,839,076 - 94,986,963 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	78,267,693 - 79,384,895 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	81,862,024 - 82,974,743 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	81,862,036 - 82,973,334 (+)	Ensembl	panpan1.1		panPan2

NRG3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	30,515,845 - 31,557,598 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	30,515,890 - 31,556,152 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	30,570,501 - 31,546,936 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	30,834,334 - 31,875,634 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	30,834,349 - 31,874,016 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	30,699,630 - 31,739,836 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	30,896,586 - 31,931,272 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	31,385,545 - 32,426,952 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101957192
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	49,019,288 - 50,047,975 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936716	1,362,574 - 2,391,432 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NRG3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	48,846,287 - 49,957,238 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	9,110,091 - 10,240,887 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nrg3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624841	4,219,084 - 5,285,240 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624841	4,213,089 - 5,285,255 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in NRG3
27466 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	ectoderm	endocrine system	mesoderm	nervous system	reproductive system
1	23	3	1	23	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001927008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT737297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT797457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT868689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT954216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU041382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU407063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU467973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU694245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP565567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000011324 ⟹ ENSSSCP00000011031

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	14	83,317,019 - 84,402,943 (+)	Ensembl

Ensembl Acc Id:

ENSSSCT00000038750 ⟹ ENSSSCP00000031677

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	14	83,317,019 - 84,402,394 (+)	Ensembl

RefSeq Acc Id:

XM_001927008 ⟹ XP_001927043

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	14	83,316,962 - 84,405,347 (+)	NCBI

Sequence:

show sequence

GGCCTCATGCCTCTAGCGCGGCCCTCGGGGGGGCGAAGGTGAAGACCGGCTCCTAGGATGAGTG
AAGGGGCGGCCGCTGCTTCGCCACCTGGAGCCGCTTCGGCAGCCGCCGCCTCGGCCGAGGAGGG
CACCGCGGCGGCTGCGGCGGCGGCGGGCGGGGGCCCGGACGGCGGCGGCGAAGGGGCGGCCGAG
CCCCCCCGGGAGTTACGCTGTAGCGACTGCATCGTGTGGAACCGGCAGCAGACGTGGCTGTGCG
TGGTGCCTCTGTTCATCGGCTTCATCGGCCTGGGGCTCAGCCTCATGCTCCTCAAATGGATCGT
GGTGGGCTCCGTCAAGGAATACGTGCCCACCGACCTGGTGGACTCCAAGGGGATGGGCCAGGAC
CCCTTCTTCCTCTCCAAGCCCAGCTCCTTCCCCAAGGCCATGGAGACCACCACTACGACAACTT
CCACCACGTCCCCAGCCACCCCCTCCGCCGGTGGCGCCGCCTCTTCCAGGACGCCCAACCGGAT
TAGCACCCGCCTGACCACCATCACGCGGGCGCCAACTCGCTTCCCCGGACACCGGGTGCCCATC
CGGGCCAGCCCGCGCTCCACCACAGCACGGAACACTNGCGCCCCCCCGACGGTCTTGTCCACGA
CAGCCCCTTTCTTCAGTAGCAGTACTCCAGGCTCCAGACCCCCGGTGCCAGGAACCCCCAGTAC
GCAGGCCATGCCCTCCTGGCCCACTGCGGCATACGCTACCTCCTCCTATCTTCATGACTCCACT
CCTTCCTGGACCCTGTCTCCCTTTCAGGATGCTGCCTCCTCCTCCTCCACTTCCTCGTCCTCCT
CCCCTACCACCACCACGCCAGAAACTAGCACCAGCCCCAAATTTCCTACGACAACATACTCCAC
CGAGCGATCCGAGCACTTCAAACCCTGCCGAGACAAGGACCTTGCCTACTGTCTCAACGATGGC
GAGTGCTTTGTGATCGAAACCTTGACCGGATCCCATAAACACTGTCGGTGCAAAGAAGGCTACC
AAGGAGTCCGTTGTGATCAATTTCTGCCGAAAACTGATTCCATCTTATCGGATCCAACAGACCA
CTTGGGGATTGAATTCATGGAGAGTGAAGAAGTTTATCAAAGGCAGGTGCTGTCAATTTCATGC
ATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCGTTCTACTTCAAAAGCAAGAAAC
AAGCTAAACAAATTCAAGAGCAGCTGAAAGAGCCACATAATGGTAAAAACTACAGTCTCAAAGC
ATCGAGCACGATGGCAAAGTCAGAGAACTTGGTGAAAAATCATGTCCAGCTGCAAAACTATTCA
AAGGCGGAAAGGCATCCTGTGACTGCATTGGGGAAAATGATGGAGTCAAGTTTTGCCGGCCCCC
AGTCATTCCCAGAGGTCCCTTCTCCTGACAGAGGAAGCCAATCTGTCAAACACCACAGGAGTCT
CTCCTCTTGCTGCAGCCCAGGGCAAAGGAGTGGTATGCTCCACAGAAACGCCTTCAGAAGGACA
CCCCCTTCTCCCAGAAGTAGGCTGGGCGGAATTGTGGGACCAGCATATCAGCAACTCGAGGAAT
CAAGGATTCCCGACCAGGATACAATACCTTGCCAAGGGATAGAGGTCAGGAAGACTATATCCCA
CCTGCCTATACAGCTGTGGTGTGTTGAAAGATCCCTGGACTTAAAGTATTCATCCAATGGTTTA
ACAACCCAACAAAATGCATCAATAAATATGCAACTGCCTTCAAGAGAGACAAATTCCTATTTTA
ATAGTTTGGATCAAAAGGACCTGATGGGATATTCATCCCCAAGGGCCAGTTCCGTACCCATCAT
CCCCTCAGTGGGTCTAGAGGAAACCTGCATGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATC
AAATGGTGCAAAAACTCCTACTCTGCTGATATTGTCAATGTGAGTATTCCAGTCAGCGATTGTC
TCATAGTGGAACAACAAGAAGTGAAAATATTGCTAGAAACTGTCCAGGAGCAGATCCGAATTCT
GACTGATGCCAGGCGGTCAGAAGACTATGAACTGGCCAGCATAGAAACCGAGGACAATGCGAGT
GAAAACACAGCCTTTCTCCCCCTAAGTCCCACGGCCAAATCAGAACGAGAGGCACAATTTGTCT
TACGAAGTGAAATACAAAGAGACCCTGCACTGACCAAGTGACTTTGAGATATAGGAATCTGTGC
ATTCTATGCTTTGCTCAACAGGAAAGAGAGGAGATTAAATACAAATTATTTATATGCATTAATT
TAAGAGCATCTACTTAGAAGAAACCAAATAGTCTATCGCCCTCATATCATAGTGTTTTTTAACA
AAATATTTTTTTAAAGGGAAAGAAATGTTTCAAGAGGGATAAAGCTTACCTAAAGCTTTTGGGT
AGAATTCTGAGTACAATTTCAGTCAGTCCCAATACCGTCCTCTTTGGCTCTTAGTAGATGTGGG
CAAATCAGACCCTCCGCCCCACAGCGCCAGTGGCCTATAAAAAAGCACTGGCAGTTACCCAGTT
TCAGTGAGATGAGCTGTGCCCTGAGGGCGGACATGCCAGTGAGCAGGTGTCCCTTGCCATTTGG
CTTGCCAATCCCAAACCCTAAATTTCTATTCACTCGACAGCCTCATCACAGGTTATGTCATGTC
AACAAATGTAGTGTTTTCTATTTACTTTTTGAAGAATGGCTAAAAGACTCTGGAAGGAGAAAGG
CAGGAGGTAGAGGGAGTCACAGGGCAATCTTAGCCACTCTTATGTGCCAGCTTCCTCTGAAATT
TGAAGGCAGAGGATCTCAGAGGAAGGTACGAAATTATTGCGGAAAAAGAGACAAAAACATCAAC
GTTGTGTCATTAAAATCATGCTAGGAGAAATGTTTTTCTTTAAGATTGTTTAGGGGCTCCAAAG
GAGCATTTCTCAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGTGT
GTGGGCTTGCTCATTCGAGCAACGGTATGCTATATGCACATGTGTTCATTGTGCATATGTGTGT
GCATGTGTGTGTGTATTAAGCTTGCTAAAATTTGTTCTGAAACATCAGGGAATCTAATATTCAG
AAAAAAATTTCCCTCTTAGATCTGTCCACTTTCAATTTTTCCATTAAGTATAAAGTTCAGTTAG
TAAATCAAGGTCACTTGCATGATGGGGGTCCTGTAAAACTCTCGATAATGCCTAGACCATTTCT
GATGTGAATATTTTTGAGAGGAACAACTATTGGCTCATTAATGATAACAGTACCACAAGGCAAG
TTGGGGATGTGTGTTTAATTTGAATCATGCATACTTAAATTATTTATAAAAGCCAGTAATCAAA
TTGTAGTTATCCATTGCTTTCTCATCATCCTCATTACTATTTATTTTGTAGCAAGTCTACTACG
TGTGGACCAAGACATTGGCTTCTGTGGTTAATACGGAAAGAATAAATTGTTGAAAACACAAAGC
CCAGACTATTCAGTTCACAGGAAGCCCCCAAAAGAACAGTAAATTGTGCTGTATGTTCATTTGG
AATAAAGCAATATTTTTTCCACTGCTAAGGTGAACTGAAACTTCTCCTGAAGATCTGTCTGTTT
TATTTACCCTTATTTTTATGGGGCATTCAAAGAAATTAGTGTTCACATAACCAGTCTTTTTCCA
GTATTGGTGGTGTTGAGTTGTTATGTTTACACTGTTTTAAATAAAAAGGCACAGTATTTGAAAG
TATTTAAAAGATTTATTTCACTTAAGTTTGGGAAAACCTTGATTAAAATTTACTTGTGGAAGAT
TCATATTCCATTGAAAGGGAATGTAACTATTTCTGAATCAAATATTGATTCTTATGGAAGATTA
AGTTCTGTTTAAAATGAATGACAAATTGCTCTTTGAGATTATTTTTTTTAATACCAGACATAAT
GCCATAGGGGAAAAGACTATTGTTTAGTGGTAACTCAAAGACTCAAATGCTGAAAATATTTTAG
TAGAAATGCATTTTATCTTTAACAAAAGGTTTGTGGTATTCATTAGATGTCCCATTATCATTCT
ATTGTTTTGAATGTAGAGGTAATACTGTTAGATCCTTAAAAGATTACAAATTTTTAACATCTAG
ATTATCTAACTACTCATTGAGAAATATTATATCTTTGGGAAAATTTTAGAAAGATGGTCTTAAC
AGGTATAGAAAAACCCTGCAAGTTGCAATATCCAGTATGTTGTGTTGAAATCAACCTCATCTTG
GGTTTTTCGCTAAAATGTTACCTGTTGCATATCTAATGGATTCATACAGAAGCCACCTAATTAG
AAGGTTGTATATTCTGTGACTTGCCACAGTTATTTTAATACATCATTTACTCTGAGAAGATCAA
AATCATCAAACTTAAGTCCTGATCCAACCGCTTATTTTTTTTAAGTACAATGATATATTATGTG
ATTATAAATAGCCTCATGCATTCTAAAGAGTATGAACAGCCAGAACCTCTACTGGTGGTCTGAT
GTAAAGTTTAGAGGTAGTAATGTCCAAATTGATAGTTGAGACTAAAATGCTCTGTTAAGAACAA
TTATTAGTGGTCAATTTCAGTGGTCATTTGTCCCCTTTTGGAGTATGAAGCTCTCCTGTGAAAA
AGGTCCACATCAAAAAGCACCTCTTTGGGCACCAGCTGACAAGTGCTGATTGCATCAAGATTCA
AAGTTGATACAATGTGGCCAACACCTGAAGCCATCGGTATCTTGTCCTTCAAGCTCACGTGCCT
ACAGAGAAGTTTTTATTTCTACAAAACACCTTTGATTTTTCATTTTTCTTGCATTTATTATGTG
AATAGATATTTGGAGATTTGGTAATTAATTAAGTTGCATATTCATTATTTCCATGAGAATGAAT
GTCACTCATTTATGACCCTGAATCATTTCCTGATGTCTTTTATTTTTTTTTAAATAAAGTTATG
TTATTCTAATTTGCCAGGGACCTCTATAGAATGCTGTTCAAAATATCTGAACAATTTTATGCTA
ATAATAGGGAAAGTTATGTTGGAAGATTGGCATCTAAATTTTCTGATTTTCCTATGTATATTAA
GTGCTCTATGTTTTACACTCTTGTCCAATATCTACCTTGCTGTGATTGAAGAACTGATTATTCG
TTGGTTGATCCAATCTCCAATGCTTTACATTATTTCCAAGTAGCAATACAGCAAGTTCCTCTGG
AGGAAAAACAGTGCTATTTTTAGGACTTCATAATGTTTTGACCATAATAAGTTCTCAAACCTAC
CAAAAAAATGAACAAAGGGGCCAAGCAGATTCCAGAGAATGACCACTGGCTTCTGGATTGATTG
ACAGCTACAACCTGAGTGGAGCTTCTGGGGACAATGACAAAGGCTTTCAATAACCAGGTCTCTA
CCCGAGTATGCTTGATATATGTAACAGTCACTTACACTTTCCCTGCAGTATGGTGCTATAGGGG
AAACCATGATTCCCTATGTGAAGGGGATGGTAATTCCTCTGACTCTAGCCCACAAACCAGAAAA
TATTGCCCTGAGACAAGTGCTGTGAAACACTTCCCAAATCAATCTATAGTATACCTAGGAACAC
AGGAGGAGGGGTGGGGTTTTTATTTGAGCTTTTGTTATCCAGGAAACATTTTATATATAAAGAA
TACTTTTTTATTATTATTCAATTGTATAGATTCAGTACCGTGTATTCAATGATAGCATGTCTAT
ACTATGTTTGTACCTTAGTCTGCAGAAATTCAGTCTTCATCCAGGAAAGACCAATACAATGTTT
CTGGGCTATTCTCTATTTTAAATTCATCCCAATACATGATGGGAAATGAGGCCTTTAAATAAGC
TTTATCTCTTCCTCTTTTATTCTTTCTTTCCCTTTTAAAGAAATAGTGAGGGAAAAGGGAGAAA
TGCATTCCTTAAGATCAACATTGTTCTCTTAATCTATTCCCTACTGTGACTACACACACACACT
CATACATATACGAGCATATATGTATGTATTAAAATATATATGTATATTACATTTAGGTGTTTGG
TTATTTTGGTAGATTTATTTTTACTTCATTTGACAAATATTAAAGTGATTGCCTCATGGAATGC
CAATGAAATAAAATCATTCAGAAATCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_001927043	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000011031.4
	ENSSSCP00000031677
	ENSSSCP00000031677.2
	ENSSSCP00070000908.1

RefSeq Acc Id:

XP_001927043 ⟸ XM_001927008

- UniProtKB:

A0A286ZJM1 (UniProtKB/TrEMBL), A0A4X1SFD1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEGAAAASPPGAASAAAASAEEGTAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTW
LCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTT
TTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTXAPPTVL
STTAPFFSSSTPGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSTSS
SSSPTTTTPETSTSPKFPTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKE
GYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKS
KKQAKQIQEQLKEPHNGKNYSLKASSTMAKSENLVKNHVQLQNYSKAERHPVTALGKMMESSFA
GPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQL
EESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERSLDLKYSSNGLTTQQNASINMQLPSRETNS
YFNSLDQKDLMGYSSPRASSVPIIPSVGLEETCMQMPGISEVKSIKWCKNSYSADIVNVSIPVS
DCLIVEQQEVKILLETVQEQIRILTDARRSEDYELASIETEDNASENTAFLPLSPTAKSEREAQ
FVLRSEIQRDPALTK

hide sequence

Ensembl Acc Id:

ENSSSCP00000011031 ⟸ ENSSSCT00000011324

Ensembl Acc Id:

ENSSSCP00000031677 ⟸ ENSSSCT00000038750

Protein Domains

EGF-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000010344	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070000524	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000011324.4	UniProtKB/TrEMBL
	ENSSSCT00000038750	ENTREZGENE
	ENSSSCT00000038750.3	UniProtKB/TrEMBL
	ENSSSCT00070001033.1	UniProtKB/TrEMBL
Gene3D-CATH	Laminin	UniProtKB/TrEMBL
InterPro	EGF-like_dom	UniProtKB/TrEMBL
	Neuregulin	UniProtKB/TrEMBL
NCBI Gene	NRG3	ENTREZGENE
PANTHER	PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM	UniProtKB/TrEMBL
	PTHR11100	UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
UniProt	A0A286ZJM1	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1SFD1	ENTREZGENE, UniProtKB/TrEMBL
	F1SEQ4_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:104011	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)