ERRFI1 (ERBB receptor feedback inhibitor 1) - Rat Genome Database

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Gene: ERRFI1 (ERBB receptor feedback inhibitor 1) Sus scrofa
Analyze
Symbol: ERRFI1
Name: ERBB receptor feedback inhibitor 1
RGD ID: 14167294
Description: ENCODES a protein that exhibits kinase binding (ortholog); SH3 domain binding (ortholog); small GTPase binding (ortholog); INVOLVED IN apoptotic process (ortholog); bile acid biosynthetic process (ortholog); cartilage development (ortholog); ASSOCIATED WITH Cardiomegaly (ortholog); chromosome 1p36 deletion syndrome (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endomembrane system (inferred); INTERACTS WITH deoxynivalenol; resveratrol
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,669,153 - 68,682,623 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,667,651 - 68,682,629 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,118,704 - 63,121,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
bile acid biosynthetic process  (IEA,ISO)
cartilage development  (IEA,ISO)
cell migration  (IEA,ISO)
cellular hyperosmotic response  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
embryo implantation  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelium development  (IEA,ISO)
fat pad development  (IEA,ISO)
gene expression  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
limb joint morphogenesis  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
liver development  (IEA,ISO)
lung alveolus development  (IEA)
lung epithelium development  (IEA)
lung vasculature development  (IEA)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (IBA,IEA,ISO)
negative regulation of epidermal growth factor-activated receptor activity  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of protein kinase activity by regulation of protein phosphorylation  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
progesterone receptor signaling pathway  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of keratinocyte differentiation  (IBA,IEA)
regulation of protein tyrosine kinase activity  (ISO)
regulation of signaling receptor activity  (ISO)
regulation of type B pancreatic cell proliferation  (ISO)
response to 1-oleoyl-sn-glycerol 3-phosphate  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to insulin  (IEA,ISO)
response to progesterone  (IEA,ISO)
response to steroid hormone  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
skeletal system development  (IEA,ISO)
skin development  (IEA,ISO)
skin morphogenesis  (IEA)
tissue homeostasis  (IEA,ISO)
uterine epithelium development  (IEA,ISO)
uterus development  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ERRFI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,669,153 - 68,682,623 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,667,651 - 68,682,629 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,118,704 - 63,121,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERRFI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818,011,727 - 8,026,309 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18,004,404 - 8,026,309 (-)EnsemblGRCh38hg38GRCh38
GRCh3718,071,787 - 8,086,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,994,381 - 8,008,943 (-)NCBINCBI36Build 36hg18NCBI36
Celera17,178,838 - 7,193,452 (-)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,219,226 - 7,233,836 (-)NCBIHuRef
CHM1_118,059,534 - 8,074,168 (-)NCBICHM1_1
T2T-CHM13v2.017,542,658 - 7,557,236 (-)NCBIT2T-CHM13v2.0
Errfi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,938,253 - 150,953,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,938,376 - 150,953,349 (+)EnsemblGRCm39 Ensembl
GRCm384150,853,796 - 150,868,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,853,919 - 150,868,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv374150,229,200 - 150,242,989 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,698,891 - 149,712,680 (+)NCBIMGSCv36mm8
Celera4153,132,313 - 153,145,977 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.5NCBI
Errfi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85166,606,841 - 166,620,124 (+)NCBIGRCr8
mRatBN7.25161,323,981 - 161,337,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,323,998 - 161,337,282 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,041,130 - 164,054,414 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,857,948 - 165,871,237 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,819,770 - 165,833,053 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,951,564 - 167,966,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,952,728 - 167,966,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,529,354 - 171,542,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,012,683 - 168,025,963 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,022,870 - 168,036,149 (+)NCBI
Celera5159,577,700 - 159,590,979 (+)NCBICelera
Cytogenetic Map5q36NCBI
Errfi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,941,143 - 4,955,693 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,941,143 - 4,955,693 (+)NCBIChiLan1.0ChiLan1.0
ERRFI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21220,202,917 - 220,217,518 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11218,844,232 - 218,858,832 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016,771,619 - 6,786,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.118,019,048 - 8,033,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl18,011,848 - 8,033,674 (-)Ensemblpanpan1.1panPan2
ERRFI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,621,964 - 61,636,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,622,550 - 61,636,148 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,630,761 - 61,645,081 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0561,838,401 - 61,852,732 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,838,401 - 61,852,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,837,612 - 61,851,932 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,702,129 - 61,716,447 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,105,524 - 62,119,850 (-)NCBIUU_Cfam_GSD_1.0
Errfi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,972,493 - 31,977,775 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,456,294 - 2,462,467 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366232,457,709 - 2,462,956 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERRFI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,738,971 - 123,753,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,738,973 - 123,755,809 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605427,772,809 - 27,787,441 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Errfi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,868,814 - 3,882,960 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,868,089 - 3,882,960 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ERRFI1
297 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000056925   ⟹   ENSSSCP00000039820
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl668,669,153 - 68,682,623 (-)Ensembl
RefSeq Acc Id: XM_021095275   ⟹   XP_020950934
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1668,667,651 - 68,682,629 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020950934   ⟸   XM_021095275
- UniProtKB: A0A287A7S3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000039820   ⟸   ENSSSCT00000056925
Protein Domains
Cdc42 binding   Mig-6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015020500 UniProtKB/TrEMBL
  ENSSSCG00025075624 UniProtKB/TrEMBL
  ENSSSCG00030070015 UniProtKB/TrEMBL
  ENSSSCG00035036845 UniProtKB/TrEMBL
  ENSSSCG00040043993 UniProtKB/TrEMBL
  ENSSSCG00045038271 UniProtKB/TrEMBL
  ENSSSCG00050069896 UniProtKB/TrEMBL
  ENSSSCG00055004534 UniProtKB/TrEMBL
  ENSSSCG00060035969 UniProtKB/TrEMBL
  ENSSSCG00070029539 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000056925 ENTREZGENE
  ENSSSCT00000056925.3 UniProtKB/TrEMBL
  ENSSSCT00015027105.1 UniProtKB/TrEMBL
  ENSSSCT00025104365.1 UniProtKB/TrEMBL
  ENSSSCT00030097945.1 UniProtKB/TrEMBL
  ENSSSCT00035048839.1 UniProtKB/TrEMBL
  ENSSSCT00040058970.1 UniProtKB/TrEMBL
  ENSSSCT00045066307.1 UniProtKB/TrEMBL
  ENSSSCT00050095303.1 UniProtKB/TrEMBL
  ENSSSCT00055008932.1 UniProtKB/TrEMBL
  ENSSSCT00060048735.1 UniProtKB/TrEMBL
  ENSSSCT00070059364.1 UniProtKB/TrEMBL
  ENSSSCT00070059365.1 UniProtKB/TrEMBL
  ENSSSCT00070059366.1 UniProtKB/TrEMBL
InterPro Cdc42_binding_dom-like UniProtKB/TrEMBL
  EGFR_SigReg_Kinase UniProtKB/TrEMBL
  Mig-6 UniProtKB/TrEMBL
NCBI Gene ERRFI1 ENTREZGENE
PANTHER ERBB RECEPTOR FEEDBACK INHIBITOR 1 UniProtKB/TrEMBL
  GENE 33 POLYPEPTIDE UniProtKB/TrEMBL
Pfam GTPase_binding UniProtKB/TrEMBL
  Inhibitor_Mig-6 UniProtKB/TrEMBL
UniProt A0A287A7S3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W2R8_PIG UniProtKB/TrEMBL
  A0A4X1W7T7_PIG UniProtKB/TrEMBL
  A0A4X1W8R9_PIG UniProtKB/TrEMBL
  A0A8D1JAE3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87784 ENTREZGENE