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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of ERBB signaling pathway
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Accession:GO:1901184 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ERBB signaling pathway.
Synonyms:exact_synonym: regulation of EGF receptor family signaling pathway;   regulation of ERBB signalling pathway;   regulation of ErbB signaling
 related_synonym: regulation of EGFR family signaling pathway


show annotations for term's descendants           Sort by:
regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:4367025 (PMID:23553667)		 GO_Central
RGD		 PMID:23553667 GO_REF:0000033 NCBI chr18:55,416,383...55,477,419 JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)		 RGD PMID:16282324 PMID:18272684 NCBI chr 4:120,461,966...120,510,756 JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:152,075,258...152,094,508 JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO
IBA		 (PMID:25178484)
GO_REF:0000033
MGI:2180578|MGI:95294 (PMID:11823423), (PMID:12754251), (PMID:23457600)		 RGD
GO_Central		 PMID:11823423 PMID:12754251 PMID:23457600 PMID:25178484 GO_REF:0000033 NCBI chr 8:53,384,656...53,468,067 JBrowse link
G Cblb Cbl proto-oncogene B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:62,058,829...62,225,904 JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO
IBA		 (PMID:10362357)
GO_REF:0000033		 RGD
GO_Central		 PMID:10362357 GO_REF:0000033 NCBI chr 1:88,567,930...88,584,709 JBrowse link
G Dab2ip DAB2 interacting protein involved_in IDA PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 3:18,915,290...19,086,282 JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (PMID:28759036) RGD PMID:28759036 NCBI chr10:86,920,014...86,933,739 JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (PMID:11823423), (PMID:23457600) RGD PMID:11823423 PMID:23457600 NCBI chr14:95,378,626...95,551,358 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IMP
IEA
ISO
IBA		 GO_REF:0000107
(PMID:19710174)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:19710174 PMID:19204184 GO_REF:0000033 GO_REF:0000107, RGD:9685562 NCBI chr 5:166,606,841...166,620,124 JBrowse link
G Itga1 integrin subunit alpha 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15592458)		 UniProt
RGD		 PMID:15592458 GO_REF:0000024 NCBI chr 2:48,379,181...48,545,336 JBrowse link
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:2,157,853...2,157,970 JBrowse link
G Mvp major vault protein involved_in ISO
IEA		 (PMID:16441665)
GO_REF:0000107		 RGD
Ensembl		 PMID:16441665 GO_REF:0000107 NCBI chr 1:191,025,259...191,052,866 JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:20353436) RGD PMID:20353436 NCBI chr 5:163,712,184...163,713,493 JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (PMID:11489947) RGD PMID:11489947 NCBI chr 1:95,298,995...95,314,902 JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15592458)		 UniProt
Ensembl
RGD		 PMID:15592458 GO_REF:0000024 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662 JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000 JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19836242) RGD PMID:19836242 NCBI chr 3:96,861,785...97,017,702 JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 2:184,262,087...184,329,839 JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 7:9,939,359...9,946,963 JBrowse link
G Sh3gl2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO (PMID:24854121) RGD PMID:24854121 NCBI chr 5:99,653,189...99,827,500 JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:3038304 (PMID:16449191) RGD PMID:16449191 NCBI chr17:24,230,064...24,253,219 JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO
IEA		 (PMID:16554368)
GO_REF:0000107		 RGD
Ensembl		 PMID:16554368 GO_REF:0000107 NCBI chr 1:106,549,035...106,578,859 JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO
IBA		 (PMID:19460345)
GO_REF:0000033		 RGD
GO_Central		 PMID:19460345 GO_REF:0000033 NCBI chr14:76,468,424...76,554,039 JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:105,191,972...105,197,642 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IDA
ISO
ISS		 PMID:17599051
(PMID:16648858)
(PMID:18046415)
GO_REF:0000024		 RGD
UniProt		 PMID:16648858 PMID:18046415 PMID:17599051 GO_REF:0000024, RGD:8553726 NCBI chr 5:166,606,841...166,620,124 JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A involved_in ISO (PMID:25744720) RGD PMID:25744720 NCBI chr 4:167,903,542...167,922,276 JBrowse link
G Psen1 presenilin 1 involved_in ISO (PMID:20208556) RGD PMID:20208556 NCBI chr 6:109,054,160...109,106,191 JBrowse link
G Psen2 presenilin 2 involved_in ISO (PMID:20208556) RGD PMID:20208556 NCBI chr13:94,499,451...94,528,419 JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:20,523,406...20,537,889 JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:7,481,039...7,512,644 JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr 1:106,549,035...106,578,859 JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:86,696,330...86,701,871 JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) RGD PMID:19460345 NCBI chr14:76,468,424...76,554,039 JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISS
ISO		 GO_REF:0000024
(PMID:19644445)		 UniProt
RGD		 PMID:19644445 GO_REF:0000024 NCBI chr 3:168,473,836...168,490,380 JBrowse link
negative regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgmn legumain involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:21292981)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21292981 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:121,544,048...121,582,495 JBrowse link
negative regulation of ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp4 acid phosphatase 4 involved_in ISO
IBA		 (PMID:15219672)
GO_REF:0000033		 RGD
GO_Central		 PMID:15219672 GO_REF:0000033 NCBI chr 1:94,736,376...94,751,871 JBrowse link
G Cadm1 cell adhesion molecule 1 IMP RGD PMID:23769722 RGD:152975632 NCBI chr 8:47,847,836...48,178,703 JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:18625725)
(PMID:17655843)		 Ensembl
RGD		 PMID:17655843 PMID:18625725 GO_REF:0000107 NCBI chr 6:40,872,936...40,920,700 JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:17655843) RGD PMID:17655843 NCBI chr 1:263,066,780...263,069,580 JBrowse link
G Afap1l2 actin filament associated protein 1-like 2 involved_in ISO
IBA		 (PMID:17412687)
GO_REF:0000033		 RGD
GO_Central		 PMID:17412687 GO_REF:0000033 NCBI chr 1:255,964,238...256,060,828 JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:25666625) RGD PMID:25666625 NCBI chr 6:52,708,602...52,729,378 JBrowse link
G Agt angiotensinogen involved_in ISO
IEA		 (PMID:15652490)
GO_REF:0000107		 RGD
Ensembl		 PMID:15652490 GO_REF:0000107 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 2:174,061,126...174,118,355 JBrowse link
G Ccdc88a coiled coil domain containing 88A involved_in ISO (PMID:20462955) RGD PMID:20462955 NCBI chr14:103,104,091...103,256,112 JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 involved_in ISO (PMID:20878056) RGD PMID:20878056 NCBI chr 9:76,084,269...76,109,111 JBrowse link
G Dgkd diacylglycerol kinase, delta involved_in ISO (PMID:17021016) RGD PMID:17021016 NCBI chr 9:95,964,507...96,055,160 JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 6:100,589,553...100,645,240 JBrowse link
G Fam83b family with sequence similarity 83, member B involved_in ISO (PMID:22886302), (PMID:23676467), (PMID:23912460) RGD PMID:22886302 PMID:23676467 PMID:23912460 NCBI chr 8:77,287,351...77,363,795 JBrowse link
G Faslg Fas ligand IMP RGD PMID:18471522 RGD:2315731 NCBI chr13:76,680,885...76,706,042 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in IMP
ISO
IEA		 (PMID:21673097)
GO_REF:0000107
(PMID:15705806)		 RGD
Ensembl		 PMID:15705806 PMID:21673097 PMID:20445128 GO_REF:0000107, RGD:4892084 NCBI chr12:15,217,217...15,222,679 JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:12890790 UniProt PMID:12890790 RGD:10047165 NCBI chr10:85,778,267...85,786,553 JBrowse link
G Hip1 huntingtin interacting protein 1 involved_in ISO
IBA		 (PMID:14732715)
GO_REF:0000033		 RGD
GO_Central		 PMID:14732715 GO_REF:0000033 NCBI chr12:26,769,868...26,904,367 JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO
IBA		 (PMID:14732715)
GO_REF:0000033		 RGD
GO_Central		 PMID:14732715 GO_REF:0000033 NCBI chr12:38,251,085...38,279,756 JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:25058496) RGD PMID:25058496 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO
IEA		 (PMID:22984561)
GO_REF:0000107		 RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Neu3 neuraminidase 3 involved_in ISO (PMID:17334392) RGD PMID:17334392 NCBI chr 1:154,137,732...154,148,879 JBrowse link
G Pde6g phosphodiesterase 6G involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:11502744)		 GO_Central
RGD		 PMID:11502744 GO_REF:0000033 NCBI chr10:105,721,502...105,726,150 JBrowse link
G Pde6h phosphodiesterase 6H involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:11502744)		 GO_Central
RGD		 PMID:11502744 GO_REF:0000033 NCBI chr 4:169,857,793...169,872,969 JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO
IEA		 (PMID:22984561)
GO_REF:0000107		 RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 1:89,181,363...89,196,308 JBrowse link
G Rala RAS like proto-oncogene A involved_in ISO UniProtKB:P11234 (PMID:34096503) RGD PMID:34096503 NCBI chr17:51,787,682...51,840,738 JBrowse link
G Ralb RAS like proto-oncogene B involved_in ISO
IEA		 UniProtKB:P11233 (PMID:34096503)
GO_REF:0000107		 RGD
Ensembl		 PMID:34096503 GO_REF:0000107 NCBI chr13:33,140,834...33,176,997 JBrowse link
G Shkbp1 Sh3kbp1 binding protein 1 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:21830225)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:21830225 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:82,636,797...82,650,330 JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEP RGD PMID:8577724 RGD:1581110 NCBI chr 6:20,286,117...20,363,350 JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (PMID:15962011) RGD PMID:15962011 NCBI chr15:82,692,291...82,697,408 JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of ISS
ISO		 GO_REF:0000024
(PMID:18625725)		 UniProt
RGD		 PMID:18625725 GO_REF:0000024 NCBI chr 1:90,324,312...90,340,627 JBrowse link
positive regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:17336907) RGD PMID:17336907 NCBI chr14:57,338,493...57,523,330 JBrowse link
positive regulation of ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtn4 reticulon 4 involved_in ISO
IEA		 (PMID:27353365)
GO_REF:0000107		 RGD
Ensembl		 PMID:27353365 GO_REF:0000107 NCBI chr14:103,450,074...103,497,687 JBrowse link
regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh13 cadherin 13 involved_in ISO (PMID:17573778) RGD PMID:17573778 NCBI chr19:46,349,562...47,387,462 JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in IMP
ISO
ISS		 PMID:15467833
(PMID:15467833)
GO_REF:0000024		 RGD
UniProt		 PMID:15467833 PMID:15467833 GO_REF:0000024, RGD:11059592 NCBI chr 1:90,171,401...90,187,810 JBrowse link
G Fer FER tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(PMID:21518868)		 UniProt
RGD		 PMID:21518868 GO_REF:0000024 NCBI chr 9:110,967,317...111,274,315 JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:24012640) RGD PMID:24012640 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mvb12a multivesicular body subunit 12A involved_in ISO
IBA
IEA		 (PMID:20654576)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:20654576 GO_REF:0000033 GO_REF:0000107 NCBI chr16:18,252,227...18,257,111 JBrowse link
G Mvb12b multivesicular body subunit 12B involved_in ISO
IBA		 (PMID:20654576)
GO_REF:0000033		 RGD
GO_Central		 PMID:20654576 GO_REF:0000033 NCBI chr 3:17,034,002...17,192,658 JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 involved_in ISO
IBA		 (PMID:27134172)
GO_REF:0000033		 RGD
GO_Central		 PMID:27134172 GO_REF:0000033 NCBI chr 4:14,020,997...14,092,931 JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:18832597)		 UniProt
GO_Central
RGD		 PMID:18832597 GO_REF:0000024 GO_REF:0000033 NCBI chr10:15,406,832...15,419,765 JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:101,833,157...101,860,283 JBrowse link
G Wdr54 WD repeat domain 54 involved_in ISO (PMID:30458214) RGD PMID:30458214 NCBI chr 4:115,654,968...115,677,979 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    regulation of biological process 13375
      regulation of response to stimulus 4324
        regulation of signal transduction 3279
          regulation of ERBB signaling pathway 77
            negative regulation of ERBB signaling pathway + 35
            positive regulation of ERBB signaling pathway + 31
            regulation of ERBB3 signaling pathway + 1
            regulation of epidermal growth factor receptor signaling pathway + 71
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        signaling 7808
          signal transduction 7250
            cell surface receptor signaling pathway 2882
              enzyme-linked receptor protein signaling pathway 1062
                cell surface receptor protein tyrosine kinase signaling pathway 671
                  ERBB signaling pathway 177
                    regulation of ERBB signaling pathway 77
                      negative regulation of ERBB signaling pathway + 35
                      positive regulation of ERBB signaling pathway + 31
                      regulation of ERBB3 signaling pathway + 1
                      regulation of epidermal growth factor receptor signaling pathway + 71
paths to the root