ADRA2A (adrenoceptor alpha 2A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ADRA2A (adrenoceptor alpha 2A) Sus scrofa
Analyze
Symbol: ADRA2A
Name: adrenoceptor alpha 2A
RGD ID: 14285279
Description: ENCODES a protein that exhibits alpha-1B adrenergic receptor binding; alpha2-adrenergic receptor activity; epinephrine binding; INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); alcohol dependence (ortholog); anxiety disorder (ortholog); FOUND IN plasma membrane; axon terminus (ortholog); dopaminergic synapse (ortholog); INTERACTS WITH zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ADRA2; adrenergic, alpha-2A-, receptor; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha2A-adrenergic receptor; PORA2AR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,469,527 - 121,470,924 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,469,572 - 121,470,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,403,894 - 132,405,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
activation of protein kinase B activity  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IDA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA)
adenylate cyclase-inhibiting adrenergic receptor signaling pathway  (IEA)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IDA)
adrenergic receptor signaling pathway  (IEA)
cellular response to hormone stimulus  (IEA)
DNA replication  (ISO)
fear response  (IEA,ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glucose homeostasis  (IEA)
negative regulation of calcium ion transmembrane transporter activity  (IDA)
negative regulation of calcium ion transport  (IDA)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of insulin secretion  (IEA)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA)
negative regulation of lipid catabolic process  (IEA)
negative regulation of uterine smooth muscle contraction  (ISO)
phospholipase C-activating adrenergic receptor signaling pathway  (IEA)
platelet activation  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of potassium ion transport  (IDA)
positive regulation of wound healing  (IEA)
presynaptic modulation of chemical synaptic transmission  (IEA)
regulation of smooth muscle contraction  (IEA)
regulation of vasoconstriction  (IEA)
response to alcohol  (ISO)
response to morphine  (ISO)
thermoception  (ISO)
vasodilation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:1354394   PMID:2170371   PMID:2174879   PMID:8385131   PMID:8661698   PMID:11683720   PMID:12529373   PMID:22301074   PMID:24801676   PMID:30032202  


Genomics

Comparative Map Data
ADRA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,469,527 - 121,470,924 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,469,572 - 121,470,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,403,894 - 132,405,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810111,077,029 - 111,080,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10111,077,029 - 111,080,907 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,836,787 - 112,840,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,826,911 - 112,830,560 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410112,826,910 - 112,830,560NCBI
Celera10106,568,388 - 106,572,263 (+)NCBICelera
Cytogenetic Map10q25.2ENTREZGENE
HuRef10106,465,554 - 106,469,429 (+)NCBIHuRef
CHM1_110113,118,624 - 113,122,499 (+)NCBICHM1_1
T2T-CHM13v2.010111,960,874 - 111,964,752 (+)NCBIT2T-CHM13v2.0
Adra2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391954,033,690 - 54,037,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1954,032,582 - 54,037,413 (+)EnsemblGRCm39 Ensembl
GRCm381954,045,259 - 54,048,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1954,044,151 - 54,048,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv371954,119,672 - 54,123,472 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361954,098,545 - 54,102,294 (+)NCBIMGSCv36mm8
Celera1956,240,003 - 56,243,840 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1949.04NCBI
Adra2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81263,066,780 - 263,069,580 (+)NCBIGRCr8
mRatBN7.21253,061,480 - 253,064,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1253,060,218 - 253,064,365 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1261,250,961 - 261,253,761 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,957,040 - 267,959,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,612,912 - 260,615,708 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
Adra2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485385,800 - 387,240 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485384,405 - 387,332 (-)NCBIChiLan1.0ChiLan1.0
ADRA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,957,240 - 122,972,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,963,626 - 122,966,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,669,860 - 107,673,685 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110111,119,153 - 111,122,369 (+)NCBIpanpan1.1PanPan1.1panPan2
ADRA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,366,989 - 22,392,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,367,780 - 22,370,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,520,055 - 22,522,948 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,892,378 - 22,895,274 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,892,610 - 22,893,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12822,451,483 - 22,454,353 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02822,458,352 - 22,461,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,592,510 - 22,595,401 (+)NCBIUU_Cfam_GSD_1.0
Adra2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,720,233 - 23,724,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,838,176 - 1,839,630 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,837,785 - 1,841,019 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19104,015,577 - 104,019,364 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9104,016,580 - 104,017,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604865,215,363 - 65,219,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,264,099 - 35,265,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,262,779 - 35,265,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADRA2A
7 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 19 1 5 9 8 19 3 3 1

Sequence


Ensembl Acc Id: ENSSSCT00000011625   ⟹   ENSSSCP00000011323
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14121,469,527 - 121,470,924 (+)Ensembl
RefSeq Acc Id: NM_214400   ⟹   NP_999565
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114121,469,572 - 121,470,924 (+)NCBI
Sequence:
RefSeq Acc Id: NP_999565   ⟸   NM_214400
- UniProtKB: P18871 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSSSCP00000011323   ⟸   ENSSSCT00000011625


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010629 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015021867 UniProtKB/Swiss-Prot
  ENSSSCG00025067450 UniProtKB/Swiss-Prot
  ENSSSCG00030054037 UniProtKB/Swiss-Prot
  ENSSSCG00035062837 UniProtKB/Swiss-Prot
  ENSSSCG00040012693 UniProtKB/Swiss-Prot
  ENSSSCG00045023737 UniProtKB/Swiss-Prot
  ENSSSCG00050042390 UniProtKB/Swiss-Prot
  ENSSSCG00055010776 UniProtKB/Swiss-Prot
  ENSSSCG00060012491 UniProtKB/Swiss-Prot
  ENSSSCG00065013945 UniProtKB/Swiss-Prot
  ENSSSCG00070008384 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000011625 ENTREZGENE
  ENSSSCT00000011625.3 UniProtKB/Swiss-Prot
  ENSSSCT00015028889.1 UniProtKB/Swiss-Prot
  ENSSSCT00025092632.1 UniProtKB/Swiss-Prot
  ENSSSCT00030075296.1 UniProtKB/Swiss-Prot
  ENSSSCT00035084472.1 UniProtKB/Swiss-Prot
  ENSSSCT00040016783.1 UniProtKB/Swiss-Prot
  ENSSSCT00045040543.1 UniProtKB/Swiss-Prot
  ENSSSCT00050057601.1 UniProtKB/Swiss-Prot
  ENSSSCT00055021131.1 UniProtKB/Swiss-Prot
  ENSSSCT00060016376.1 UniProtKB/Swiss-Prot
  ENSSSCT00065018548.1 UniProtKB/Swiss-Prot
  ENSSSCT00070016176.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRA2A_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report ssc:399501 UniProtKB/Swiss-Prot
NCBI Gene ADRA2A ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  ALPHA-2A ADRENERGIC RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCA2AR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt ADA2A_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:85156 ENTREZGENE