Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of ERBB signaling pathway
go back to main search page
Accession:GO:1901185 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway.
Synonyms:exact_synonym: down regulation of EGF receptor family signaling pathway;   down regulation of ERBB signaling pathway;   down regulation of ERBB signalling pathway;   down regulation of ErbB signaling;   downregulation of EGF receptor family signaling pathway;   downregulation of ERBB signaling pathway;   downregulation of ERBB signalling pathway;   downregulation of ErbB signaling;   inhibition of EGF receptor family signaling pathway;   inhibition of ERBB signalling pathway;   inhibition of ErbB signaling;   negative regulation of EGF receptor family signaling pathway;   negative regulation of ERBB signalling pathway;   negative regulation of ErbB signaling
 narrow_synonym: inhibition of ERBB signaling pathway
 related_synonym: down regulation of EGFR family signaling pathway;   downregulation of EGFR family signaling pathway;   inhibition of EGFR family signaling pathway;   negative regulation of EGFR family signaling pathway


show annotations for term's descendants           Sort by:
negative regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgmn legumain involved_in ISS
ISO		 GO_REF:0000024
(MGI:5008720|PMID:21292981)		 UniProt
RGD		 PMID:21292981 GO_REF:0000024 MGI:5008720 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)		 RGD PMID:16282324 PMID:18272684 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:131,621,875...131,641,127
Ensembl chr 3:131,621,880...131,641,192 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (PMID:25178484)
MGI:2180578|MGI:95294 (PMID:11823423), (PMID:12754251), (PMID:23457600)		 RGD PMID:11823423 PMID:12754251 PMID:23457600 PMID:25178484 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO (PMID:10362357) RGD PMID:10362357 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in IDA PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (MGI:6101044|PMID:28759036) RGD PMID:28759036 MGI:6101044 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (PMID:11823423), (PMID:23457600) RGD PMID:11823423 PMID:23457600 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IMP
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(MGI:4366137|PMID:19710174)		 GO_Central
Ensembl
RGD		 PMID:19710174 PMID:19204184 GO_REF:0000033 GO_REF:0000107 MGI:4366137, RGD:9685562 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Itga1 integrin subunit alpha 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5488887|PMID:15592458)		 UniProt
RGD		 PMID:15592458 GO_REF:0000024 MGI:5488887 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
G Mvp major vault protein involved_in ISO
IEA		 (PMID:16441665)
GO_REF:0000107		 RGD
Ensembl		 PMID:16441665 GO_REF:0000107 NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:20353436) RGD PMID:20353436 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (MGI:3526674|PMID:11489947) RGD PMID:11489947 MGI:3526674 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15592458)		 UniProt
Ensembl
RGD		 PMID:15592458 GO_REF:0000024 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19836242) RGD PMID:19836242 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823 		JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:3038304 (PMID:16449191) RGD PMID:16449191 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO
IEA		 (PMID:16554368)
GO_REF:0000107		 RGD
Ensembl		 PMID:16554368 GO_REF:0000107 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) RGD PMID:19460345 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
negative regulation of ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp4 acid phosphatase 4 involved_in ISO
IBA		 (PMID:15219672)
GO_REF:0000033		 RGD
GO_Central		 PMID:15219672 GO_REF:0000033 NCBI chr 1:94,736,376...94,751,871
Ensembl chr 1:94,735,514...94,744,623 		JBrowse link
G Cadm1 cell adhesion molecule 1 IMP RGD PMID:23769722 RGD:152975632 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19870
    cellular process 18312
      signal transduction 7038
        negative regulation of signal transduction 1449
          negative regulation of ERBB signaling pathway 25
            negative regulation of ERBB3 signaling pathway 0
            negative regulation of ERBB4 signaling pathway 2
            negative regulation of epidermal growth factor receptor signaling pathway + 22
Path 2
Term Annotations click to browse term
  biological_process 19870
    biological regulation 13395
      regulation of biological process 12997
        regulation of cellular process 12445
          signal transduction 7038
            cell surface receptor signaling pathway 2823
              enzyme-linked receptor protein signaling pathway 1035
                cell surface receptor protein tyrosine kinase signaling pathway 645
                  ERBB signaling pathway 123
                    regulation of ERBB signaling pathway 67
                      negative regulation of ERBB signaling pathway 25
                        negative regulation of ERBB3 signaling pathway 0
                        negative regulation of ERBB4 signaling pathway 2
                        negative regulation of epidermal growth factor receptor signaling pathway + 22
paths to the root