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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ERBB signaling pathway
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Accession:GO:1901185 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway.
Synonyms:exact_synonym: down regulation of EGF receptor family signaling pathway;   down regulation of ERBB signaling pathway;   down regulation of ERBB signalling pathway;   down regulation of ErbB signaling;   downregulation of EGF receptor family signaling pathway;   downregulation of ERBB signaling pathway;   downregulation of ERBB signalling pathway;   downregulation of ErbB signaling;   inhibition of EGF receptor family signaling pathway;   inhibition of ERBB signalling pathway;   inhibition of ErbB signaling;   negative regulation of EGF receptor family signaling pathway;   negative regulation of ERBB signalling pathway;   negative regulation of ErbB signaling
 narrow_synonym: inhibition of ERBB signaling pathway
 related_synonym: down regulation of EGFR family signaling pathway;   downregulation of EGFR family signaling pathway;   inhibition of EGFR family signaling pathway;   negative regulation of EGFR family signaling pathway


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negative regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgmn legumain involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:5008720|PMID:21292981)
Ensembl
UniProt
RGD
PMID:21292981 GO_REF:0000024 GO_REF:0000107 MGI:5008720 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726
JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)
RGD PMID:16282324 PMID:18272684 NCBI chr 4:119,910,461...119,963,065
Ensembl chr 4:119,910,478...119,959,173
JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:138,378,032...138,397,944
Ensembl chr 3:138,378,202...138,397,870
JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (PMID:25178484) RGD PMID:25178484 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO (PMID:10362357) RGD PMID:10362357 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Dab2ip DAB2 interacting protein involved_in IDA PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (MGI:6101044|PMID:28759036) RGD PMID:28759036 MGI:6101044 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IMP
ISO
IBA
(MGI:4366137|PMID:19710174)
PMID:21873635
RGD PMID:19710174, PMID:19204184, PMID:21873635 MGI:4366137, RGD:9685562, RGD:13792537 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Itga1 integrin subunit alpha 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5488887|PMID:15592458)
UniProt
RGD
PMID:15592458 GO_REF:0000024 MGI:5488887 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Mvp major vault protein involved_in ISO
IEA
(PMID:16441665)
GO_REF:0000107
RGD
Ensembl
PMID:16441665 GO_REF:0000107 NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047
JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:20353436) RGD PMID:20353436 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (MGI:3526674|PMID:11489947) RGD PMID:11489947 MGI:3526674 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:15592458)
UniProt
RGD
PMID:15592458 GO_REF:0000024 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19836242) RGD PMID:19836242 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 2:198,852,392...198,920,000
Ensembl chr 2:198,852,500...198,919,995
JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 7:12,820,796...12,828,325
Ensembl chr 7:12,820,840...12,828,334
JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:3038304 (MGI:3616382|PMID:16449191) RGD PMID:16449191 MGI:3616382 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) RGD PMID:19460345 NCBI chr14:81,725,513...81,811,142
Ensembl chr14:81,725,513...81,811,142
JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cblb Cbl proto-oncogene B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO
IBA
(PMID:10362357)
PMID:21873635
RGD PMID:10362357, PMID:21873635 RGD:13792537 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:109,073,678...109,079,348
Ensembl chr10:109,073,678...109,079,348
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
ISO
IDA
GO_REF:0000024
(MGI:3629275|PMID:16648858)
PMID:17599051
(PMID:18046415)
UniProt
RGD
PMID:16648858 PMID:18046415, PMID:17599051 GO_REF:0000024 MGI:3629275, RGD:8553726 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A involved_in ISO (MGI:5635952|PMID:25744720) RGD PMID:25744720 MGI:5635952 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Psen1 presenilin 1 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psen2 presenilin 2 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:24,056,383...24,070,868
Ensembl chr15:24,056,383...24,070,857
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:89,174,684...89,180,165
Ensembl chr10:89,174,684...89,180,160
JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO
IBA
(PMID:19460345)
PMID:21873635
RGD PMID:19460345, PMID:21873635 RGD:13792537 NCBI chr14:81,725,513...81,811,142
Ensembl chr14:81,725,513...81,811,142
JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISO
ISS
(PMID:19644445)
GO_REF:0000024
RGD
UniProt
PMID:19644445 GO_REF:0000024 NCBI chr 3:176,865,078...176,881,603
Ensembl chr 3:176,865,156...176,881,549
JBrowse link
negative regulation of ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp4 acid phosphatase 4 involved_in IBA
ISO
PMID:21873635
(PMID:15219672)
RGD PMID:15219672, PMID:21873635 RGD:13792537 NCBI chr 1:100,226,311...100,234,536
Ensembl chr 1:100,227,157...100,234,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      signal transduction 6881
        negative regulation of signal transduction 1265
          negative regulation of ERBB signaling pathway 30
            negative regulation of ERBB3 signaling pathway 0
            negative regulation of ERBB4 signaling pathway 1
            negative regulation of epidermal growth factor receptor signaling pathway + 28
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of biological process 12773
        regulation of cellular process 12275
          signal transduction 6881
            cell surface receptor signaling pathway 2774
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein tyrosine kinase signaling pathway 613
                  ERBB signaling pathway 115
                    regulation of ERBB signaling pathway 77
                      negative regulation of ERBB signaling pathway 30
                        negative regulation of ERBB3 signaling pathway 0
                        negative regulation of ERBB4 signaling pathway 1
                        negative regulation of epidermal growth factor receptor signaling pathway + 28
paths to the root