Rnf126 (ring finger protein 126) - Rat Genome Database

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Gene: Rnf126 (ring finger protein 126) Rattus norvegicus
Analyze
Symbol: Rnf126
Name: ring finger protein 126
RGD ID: 1306011
Description: Predicted to enable epidermal growth factor receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of epidermal growth factor receptor signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human RNF126 (ring finger protein 126); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase RNF126; LOC314613; MGC124770
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,590,013 - 10,597,585 (+)NCBIGRCr8
mRatBN7.279,939,359 - 9,946,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,938,229 - 9,946,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,820,464 - 12,827,752 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,698,545 - 14,705,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,557,874 - 12,565,162 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,820,796 - 12,828,325 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,820,840 - 12,828,334 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,991,016 - 12,998,529 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,454,326 - 11,461,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,454,379 - 11,461,302 (+)NCBI
Celera78,112,972 - 8,120,260 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:23026136   PMID:23277564   PMID:23418353   PMID:24275455   PMID:24981174   PMID:28383811  


Genomics

Comparative Map Data
Rnf126
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,590,013 - 10,597,585 (+)NCBIGRCr8
mRatBN7.279,939,359 - 9,946,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,938,229 - 9,946,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,820,464 - 12,827,752 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,698,545 - 14,705,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,557,874 - 12,565,162 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,820,796 - 12,828,325 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,820,840 - 12,828,334 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,991,016 - 12,998,529 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,454,326 - 11,461,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,454,379 - 11,461,302 (+)NCBI
Celera78,112,972 - 8,120,260 (+)NCBICelera
Cytogenetic Map7q11NCBI
RNF126
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819647,526 - 663,214 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19647,526 - 663,233 (-)EnsemblGRCh38hg38GRCh38
GRCh3719647,526 - 663,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619598,526 - 614,227 (-)NCBINCBI36Build 36hg18NCBI36
Celera19154,322 - 170,071 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19417,361 - 433,064 (-)NCBIHuRef
CHM1_119647,187 - 662,920 (-)NCBICHM1_1
T2T-CHM13v2.019601,753 - 617,249 (-)NCBIT2T-CHM13v2.0
Rnf126
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,594,349 - 79,607,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,594,349 - 79,602,786 (-)EnsemblGRCm39 Ensembl
GRCm381079,758,515 - 79,771,448 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,758,515 - 79,766,952 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,221,260 - 79,229,686 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,161,668 - 79,170,053 (-)NCBIMGSCv36mm8
Celera1080,773,108 - 80,791,932 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Rnf126
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,095,336 - 7,102,757 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,083,952 - 7,098,442 (+)NCBIChiLan1.0ChiLan1.0
RNF126
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,969,822 - 4,988,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,211,553 - 4,226,693 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019491,699 - 494,175 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl19614,236 - 618,659 (-)Ensemblpanpan1.1panPan2
RNF126
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,890,333 - 57,899,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,891,413 - 57,898,863 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,694,175 - 57,701,870 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,634,727 - 58,642,433 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12057,688,864 - 57,696,560 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,168,322 - 58,176,002 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,371,682 - 58,379,389 (+)NCBIUU_Cfam_GSD_1.0
LOC101961559
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,572,863 - 217,603,060 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588229,508 - 237,969 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936588255,639 - 260,291 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588231,723 - 237,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF126
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,673,353 - 77,683,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,673,302 - 77,683,312 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RNF126
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16392,717 - 409,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,561,985 - 8,593,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf126
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,856,470 - 7,869,926 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,856,822 - 7,865,644 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnf126
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:117
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000012317
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 40 32 12 32 3 74 29 40 8
Low 11 17 9 7 9 8 8 6 1 3 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012317   ⟹   ENSRNOP00000012317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,938,229 - 9,946,738 (+)Ensembl
Rnor_6.0 Ensembl712,820,840 - 12,828,334 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114773   ⟹   ENSRNOP00000096321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,938,229 - 9,946,511 (+)Ensembl
RefSeq Acc Id: NM_001033702   ⟹   NP_001028874
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,590,072 - 10,597,360 (+)NCBI
mRatBN7.279,939,450 - 9,946,738 (+)NCBI
Rnor_6.0712,820,812 - 12,828,100 (+)NCBI
Rnor_5.0712,991,016 - 12,998,529 (+)NCBI
RGSC_v3.4711,454,326 - 11,461,614 (+)RGD
Celera78,112,972 - 8,120,260 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240899   ⟹   XP_006240961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,590,026 - 10,597,585 (+)NCBI
mRatBN7.279,939,389 - 9,946,963 (+)NCBI
Rnor_6.0712,820,796 - 12,828,325 (+)NCBI
Rnor_5.0712,991,016 - 12,998,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594811   ⟹   XP_017450300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,590,013 - 10,597,585 (+)NCBI
mRatBN7.279,939,359 - 9,946,963 (+)NCBI
Rnor_6.0712,820,796 - 12,828,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063263409   ⟹   XP_063119479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,590,023 - 10,597,585 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001028874   ⟸   NM_001033702
- UniProtKB: Q499Q1 (UniProtKB/TrEMBL),   F7ESD4 (UniProtKB/TrEMBL),   A0A8I6GM09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240961   ⟸   XM_006240899
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450300   ⟸   XM_017594811
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000012317   ⟸   ENSRNOT00000012317
RefSeq Acc Id: ENSRNOP00000096321   ⟸   ENSRNOT00000114773
RefSeq Acc Id: XP_063119479   ⟸   XM_063263409
- Peptide Label: isoform X3
Protein Domains
E3 ubiquitin-protein ligase RNF126-like zinc-ribbon   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7ESD4-F1-model_v2 AlphaFold F7ESD4 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695053
Promoter ID:EPDNEW_R5577
Type:initiation region
Name:Rnf126_1
Description:ring finger protein 126
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,820,811 - 12,820,871EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306011 AgrOrtholog
BioCyc Gene G2FUF-34887 BioCyc
Ensembl Genes ENSRNOG00000009028 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012317 ENTREZGENE
  ENSRNOT00000012317.7 UniProtKB/TrEMBL
  ENSRNOT00000114773.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621533 IMAGE-MGC_LOAD
InterPro RNF126-like_zinc-ribbon UniProtKB/TrEMBL
  RNF126_RING-H2 UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:314613 UniProtKB/TrEMBL
MGC_CLONE MGC:124770 IMAGE-MGC_LOAD
NCBI Gene 314613 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE PRAJA UniProtKB/TrEMBL
  PTHR15710:SF21 UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/TrEMBL
  zinc_ribbon_9 UniProtKB/TrEMBL
PhenoGen Rnf126 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009028 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I6GM09 ENTREZGENE, UniProtKB/TrEMBL
  A6K8X6_RAT UniProtKB/TrEMBL
  F7ESD4 ENTREZGENE
  Q499Q1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7ESD4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Rnf126  ring finger protein 126  Rnf126_predicted  ring finger protein 126 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rnf126_predicted  ring finger protein 126 (predicted)      Symbol and Name status set to approved 70820 APPROVED