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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of epidermal growth factor receptor signaling pathway
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Accession:GO:0042059 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms:exact_synonym: down regulation of epidermal growth factor receptor signaling pathway;   downregulation of epidermal growth factor receptor signaling pathway;   negative regulation of EGF receptor signaling pathway;   negative regulation of EGF receptor signalling pathway;   negative regulation of EGFR signaling pathway
 narrow_synonym: inhibition of epidermal growth factor receptor signaling pathway


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negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (PMID:25178484)
MGI:2180578|MGI:95294 (MGI:5502501|PMID:23457600), (MGI:7471045|PMID:12754251), (MGI:7471047|PMID:11823423)		 RGD PMID:11823423 PMID:12754251 PMID:23457600 PMID:25178484 MGI:5502501 MGI:7471045 MGI:7471047 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO (PMID:10362357) RGD PMID:10362357 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in IDA PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (MGI:6101044|PMID:28759036) RGD PMID:28759036 MGI:6101044 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (MGI:5502501|PMID:23457600), (MGI:7471047|PMID:11823423) RGD PMID:11823423 PMID:23457600 MGI:5502501 MGI:7471047 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IMP
IBA
ISO		 PMID:21873635
(MGI:4366137|PMID:19710174)		 RGD PMID:19710174 PMID:19204184 PMID:21873635 MGI:4366137, RGD:9685562, RGD:13792537 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Itga1 integrin subunit alpha 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5488887|PMID:15592458)		 UniProt
RGD		 PMID:15592458 GO_REF:0000024 MGI:5488887 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Mvp major vault protein involved_in ISO
IEA		 (PMID:16441665)
GO_REF:0000107		 RGD
Ensembl		 PMID:16441665 GO_REF:0000107 NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:20353436) RGD PMID:20353436 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (MGI:3526674|PMID:11489947) RGD PMID:11489947 MGI:3526674 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:15592458)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15592458 GO_REF:0000024 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19836242) RGD PMID:19836242 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 2:184,262,087...184,329,841
Ensembl chr 2:184,262,371...184,329,823 		JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:3038304 (MGI:3616382|PMID:16449191) RGD PMID:16449191 MGI:3616382 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) RGD PMID:19460345 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)		 RGD PMID:16282324 PMID:18272684 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:131,621,709...131,641,205
Ensembl chr 3:131,621,880...131,641,192 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO
IBA		 (PMID:10362357)
PMID:21873635		 RGD PMID:10362357 PMID:21873635 RGD:13792537 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
IEA
ISO
IDA		 GO_REF:0000024
GO_REF:0000107
(MGI:3629275|PMID:16648858)
PMID:17599051
(PMID:18046415)		 UniProt
Ensembl
RGD		 PMID:16648858 PMID:18046415 PMID:17599051 GO_REF:0000024 GO_REF:0000107 MGI:3629275, RGD:8553726 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A involved_in ISO (MGI:5635952|PMID:25744720) RGD PMID:25744720 MGI:5635952 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO
IEA		 (PMID:16973552)
GO_REF:0000107		 RGD
Ensembl		 PMID:16973552 GO_REF:0000107 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO
IBA		 (PMID:19460345)
PMID:21873635		 RGD PMID:19460345 PMID:21873635 RGD:13792537 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISO
ISS		 (PMID:19644445)
GO_REF:0000024		 RGD
UniProt		 PMID:19644445 GO_REF:0000024 NCBI chr 3:168,473,836...168,490,380
Ensembl chr 3:168,473,981...168,490,380 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    cellular process 17392
      signal transduction 7070
        negative regulation of signal transduction 1403
          negative regulation of ERBB signaling pathway 34
            negative regulation of epidermal growth factor receptor signaling pathway 31
              epidermal growth factor catabolic process 2
              negative regulation of epidermal growth factor receptor signaling pathway involved in heart process 2
              negative regulation of epidermal growth factor-activated receptor activity 14
Path 2
Term Annotations click to browse term
  biological_process 19818
    biological regulation 13487
      regulation of biological process 13074
        regulation of cellular process 11066
          signal transduction 7070
            cell surface receptor signaling pathway 2794
              enzyme-linked receptor protein signaling pathway 1031
                transmembrane receptor protein tyrosine kinase signaling pathway 644
                  ERBB signaling pathway 124
                    regulation of ERBB signaling pathway 74
                      negative regulation of ERBB signaling pathway 34
                        negative regulation of epidermal growth factor receptor signaling pathway 31
                          epidermal growth factor catabolic process 2
                          negative regulation of epidermal growth factor receptor signaling pathway involved in heart process 2
                          negative regulation of epidermal growth factor-activated receptor activity 14
paths to the root