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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of leukocyte mediated cytotoxicity
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Accession:GO:0001910 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
Synonyms:exact_synonym: regulation of immune cell mediated cell death;   regulation of immune cell mediated cell killing;   regulation of immune cell mediated cytotoxicity;   regulation of leucocyte mediated cytotoxicity


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regulation of leukocyte mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ICAM1 intercellular adhesion molecule 1 involved_in TAS (PMID:16038038) BHF-UCL PMID:16038038 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
negative regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FCGR2B Fc gamma receptor IIb involved_in TAS (PMID:26683154) ARUK-UCL PMID:26683154 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 involved_in IDA (PMID:18424730) UniProt PMID:18424730 NCBI chr19:42,507,306...42,528,481
Ensembl chr19:42,507,304...42,561,234 		JBrowse link
G FCGR2B Fc gamma receptor IIb involved_in TAS (PMID:26683154) ARUK-UCL PMID:26683154 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IMP (PMID:32647003) UniProt PMID:32647003 NCBI chr12:54,497,752...54,548,243
Ensembl chr12:54,497,752...54,548,243 		JBrowse link
negative regulation of microglial cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CX3CR1 C-X3-C motif chemokine receptor 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HLA-F major histocompatibility complex, class I, F involved_in IDA (PMID:24018270) UniProt PMID:24018270 NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) UniProt PMID:23408620 MGI:5491117 NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560 		JBrowse link
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IMP (PMID:18604210) UniProt PMID:18604210 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G CLEC12B C-type lectin domain family 12 member B involved_in IMP (PMID:17562706) UniProt PMID:17562706 NCBI chr12:10,006,209...10,018,800
Ensembl chr12:10,010,627...10,018,796 		JBrowse link
G CRK CRK proto-oncogene, adaptor protein involved_in ISO
IEA		 RGD
Ensembl		 PMID:18835194 GO_REF:0000107 RGD:11568650 NCBI chr17:1,420,693...1,456,232
Ensembl chr17:1,420,689...1,463,162 		JBrowse link
G GFER growth factor, augmenter of liver regeneration involved_in ISO
IEA		 RGD
Ensembl		 PMID:9021955 GO_REF:0000107 RGD:9685777 NCBI chr16:1,984,193...1,987,749
Ensembl chr16:1,984,193...1,987,749 		JBrowse link
G HLA-E major histocompatibility complex, class I, E involved_in IDA (PMID:10799855), (PMID:17179229), (PMID:23335510), (PMID:9486650) UniProt PMID:9486650 PMID:10799855 PMID:17179229 PMID:23335510 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
G HLA-F major histocompatibility complex, class I, F involved_in IDA (PMID:24018270) UniProt PMID:24018270 NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528 		JBrowse link
G HLA-G major histocompatibility complex, class I, G involved_in IDA
IMP		 (PMID:10190900)
(PMID:12874224)		 UniProt PMID:10190900 PMID:12874224 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G IGF2 insulin like growth factor 2 ISO RGD PMID:9021955 RGD:9685777 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G KIR2DL4 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 involved_in IDA (PMID:10190900) UniProt PMID:10190900 NCBI chr19:54,803,610...54,814,517
Ensembl chr19:54,803,610...54,814,517 		JBrowse link
G KLRC1 killer cell lectin like receptor C1 involved_in IDA
IBA		 (PMID:9485206), (PMID:9486650) UniProt
GO_Central		 PMID:9485206 PMID:9486650 GO_REF:0000033 NCBI chr12:10,442,264...10,454,685
Ensembl chr12:10,442,264...10,454,685 		JBrowse link
G KLRD1 killer cell lectin like receptor D1 involved_in IDA (PMID:9486650) UniProt PMID:9486650 NCBI chr12:10,238,961...10,329,608
Ensembl chr12:10,226,058...10,329,608 		JBrowse link
G LGALS9 galectin 9 involved_in IDA (PMID:23408620) UniProt PMID:23408620 NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560 		JBrowse link
G LILRB1 leukocyte immunoglobulin like receptor B1 involved_in IDA (PMID:12874224), (PMID:18398485) UniProt PMID:12874224 PMID:18398485 NCBI chr19:54,616,322...54,638,022
Ensembl chr19:54,617,158...54,638,022 		JBrowse link
G MICA MHC class I polypeptide-related sequence A involved_in IMP (PMID:20068167) CACAO PMID:20068167 NCBI chr 6:31,400,711...31,415,315
Ensembl chr 6:31,399,784...31,415,315 		JBrowse link
G SH2D1B SH2 domain containing 1B acts_upstream_of_or_within ISO (PMID:16127454) MGI PMID:16127454 NCBI chr 1:162,395,268...162,412,136
Ensembl chr 1:162,395,268...162,412,138 		JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 involved_in IMP (PMID:23696226) UniProt PMID:23696226 NCBI chr19:42,507,306...42,528,481
Ensembl chr19:42,507,304...42,561,234 		JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:157,085,832...157,109,044
Ensembl chr 5:157,085,422...157,142,869 		JBrowse link
G KLRC4-KLRK1 KLRC4-KLRK1 readthrough ISO RGD PMID:12782717 RGD:1299590 NCBI chr12:10,372,353...10,410,146
Ensembl chr12:10,372,353...10,410,146
Ensembl chr12:10,372,353...10,410,146 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in IDA (PMID:24586048) ARUK-UCL PMID:24586048 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
negative regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 involved_in IDA (PMID:18424730) UniProt PMID:18424730 NCBI chr19:42,507,306...42,528,481
Ensembl chr19:42,507,304...42,561,234 		JBrowse link
G HLA-G major histocompatibility complex, class I, G involved_in IDA (PMID:11290782) UniProt PMID:11290782 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G IL7R interleukin 7 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9215624) Ensembl
MGI		 PMID:9215624 GO_REF:0000107 NCBI chr 5:35,856,891...35,879,603
Ensembl chr 5:35,852,695...35,879,603 		JBrowse link
G KLRC1 killer cell lectin like receptor C1 involved_in IDA
IBA		 (PMID:9485206) UniProt
GO_Central		 PMID:9485206 GO_REF:0000033 NCBI chr12:10,442,264...10,454,685
Ensembl chr12:10,442,264...10,454,685 		JBrowse link
G KLRD1 killer cell lectin like receptor D1 involved_in IDA (PMID:9485206) UniProt PMID:9485206 NCBI chr12:10,238,961...10,329,608
Ensembl chr12:10,226,058...10,329,608 		JBrowse link
G LILRB1 leukocyte immunoglobulin like receptor B1 involved_in IDA (PMID:21213105) UniProt PMID:21213105 NCBI chr19:54,616,322...54,638,022
Ensembl chr19:54,617,158...54,638,022 		JBrowse link
G PPP3CB protein phosphatase 3 catalytic subunit beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18097009) Ensembl
MGI		 PMID:18097009 GO_REF:0000107 NCBI chr10:73,436,433...73,496,024
Ensembl chr10:73,436,433...73,496,024 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,757,476 		JBrowse link
negative regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MUC4 mucin 4, cell surface associated ISO RGD PMID:10232613 RGD:2303754 NCBI chr 3:195,746,771...195,811,929
Ensembl chr 3:195,746,765...195,811,973 		JBrowse link
positive regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HLA-E major histocompatibility complex, class I, E involved_in IDA (PMID:30134159) UniProt PMID:30134159 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
positive regulation of leukocyte mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:8103296 RGD:8549560 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G NOS2 nitric oxide synthase 2 involved_in TAS (PMID:10450191) BHF-UCL PMID:10450191 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
positive regulation of microglial cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGAM integrin subunit alpha M involved_in ISS UniProt GO_REF:0000024 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr11:47,354,860...47,378,547
Ensembl chr11:47,354,860...47,409,369 		JBrowse link
G STAP1 signal transducing adaptor family member 1 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:67,558,727...67,607,337
Ensembl chr 4:67,558,727...67,607,337 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295 		JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IMP (PMID:23632890) UniProt PMID:23632890 NCBI chr16:71,729,000...71,808,834
Ensembl chr16:71,729,000...71,809,201 		JBrowse link
G CD160 CD160 molecule involved_in IDA (PMID:19109136) UniProt PMID:19109136 NCBI chr 1:145,719,499...145,739,288
Ensembl chr 1:145,719,471...145,739,288 		JBrowse link
G HLA-F major histocompatibility complex, class I, F involved_in IDA (PMID:27455421) UniProt PMID:27455421 NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528 		JBrowse link
G KLRC2 killer cell lectin like receptor C2 involved_in IDA (PMID:21825173) UniProt PMID:21825173 NCBI chr12:10,430,599...10,436,010
Ensembl chr12:10,426,854...10,442,300 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IMP (PMID:23632890) UniProt PMID:23632890 NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672 		JBrowse link
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IMP (PMID:23632890) UniProt PMID:23632890 NCBI chr16:71,729,000...71,808,834
Ensembl chr16:71,729,000...71,809,201 		JBrowse link
G CADM1 cell adhesion molecule 1 involved_in ISS
IDA		 (PMID:12826663)
(PMID:15811952)		 UniProt PMID:12826663 PMID:15811952 NCBI chr11:115,169,236...115,504,415
Ensembl chr11:115,169,218...115,504,957 		JBrowse link
G CD160 CD160 molecule involved_in IDA (PMID:12486241), (PMID:17307798) UniProt PMID:12486241 PMID:17307798 NCBI chr 1:145,719,499...145,739,288
Ensembl chr 1:145,719,471...145,739,288 		JBrowse link
G CD226 CD226 molecule involved_in IMP (PMID:16304049) BHF-UCL PMID:16304049 NCBI chr18:69,853,274...69,961,773
Ensembl chr18:69,831,158...69,961,803 		JBrowse link
G CRTAM cytotoxic and regulatory T cell molecule involved_in IEA
IDA		 (PMID:15811952) Ensembl
HGNC-UCL		 PMID:15811952 GO_REF:0000107 NCBI chr11:122,838,500...122,872,643
Ensembl chr11:122,838,500...122,872,643 		JBrowse link
G GIMAP5 GTPase, IMAP family member 5 ISO RGD PMID:15100275 RGD:2303778 NCBI chr 7:150,737,418...150,743,646
Ensembl chr 7:150,722,253...150,750,033 		JBrowse link
G HLA-E major histocompatibility complex, class I, E involved_in IDA (PMID:23335510) UniProt PMID:23335510 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
G HLA-G major histocompatibility complex, class I, G acts_upstream_of_or_within ISO (PMID:16476767) MGI PMID:16476767 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G IL12A interleukin 12A involved_in IDA (PMID:2204066) UniProt PMID:2204066 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL18RAP interleukin 18 receptor accessory protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15843532) Ensembl
MGI		 PMID:15843532 GO_REF:0000107 NCBI chr 2:102,418,621...102,452,565
Ensembl chr 2:102,418,689...102,452,565 		JBrowse link
G IL21 interleukin 21 involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO
IBA		 (PMID:18005035)
(PMID:14764669)		 CACAO
TreeGrafter
MGI
GO_Central		 PMID:14764669 PMID:18005035 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066 		JBrowse link
G KLRC1 killer cell lectin like receptor C1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr12:10,442,264...10,454,685
Ensembl chr12:10,442,264...10,454,685 		JBrowse link
G KLRC2 killer cell lectin like receptor C2 involved_in IDA
IBA		 (PMID:9754572) UniProt
GO_Central		 PMID:9754572 GO_REF:0000033 NCBI chr12:10,430,599...10,436,010
Ensembl chr12:10,426,854...10,442,300 		JBrowse link
G KLRC3 killer cell lectin like receptor C3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:10,412,315...10,420,595
Ensembl chr12:10,412,315...10,420,595 		JBrowse link
G KLRC4 killer cell lectin like receptor C4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:10,407,384...10,409,757
Ensembl chr12:10,407,384...10,409,757 		JBrowse link
G KLRC4-KLRK1 KLRC4-KLRK1 readthrough involved_in IDA
IBA
IEA		 (PMID:15294961) UniProt
GO_Central
InterPro
Ensembl		 PMID:15294961 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:10,372,353...10,410,146
Ensembl chr12:10,372,353...10,410,146
Ensembl chr12:10,372,353...10,410,146 		JBrowse link
G KLRD1 killer cell lectin like receptor D1 involved_in IDA
IEA
IBA		 (PMID:9754572) UniProt
TreeGrafter
GO_Central		 PMID:9754572 GO_REF:0000033 GO_REF:0000118 NCBI chr12:10,238,961...10,329,608
Ensembl chr12:10,226,058...10,329,608 		JBrowse link
G KLRF2 killer cell lectin like receptor F2 acts_upstream_of_or_within ISO (PMID:10229823), (PMID:10229828) MGI PMID:10229823 PMID:10229828 NCBI chr12:9,881,489...9,895,833
Ensembl chr12:9,881,489...9,895,833 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IDA		 (PMID:12645935)
(PMID:15294961)		 Ensembl
TreeGrafter
MGI
GO_Central
InterPro
UniProt		 PMID:12645935 PMID:15294961 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:10,372,353...10,390,041
Ensembl chr12:10,372,353...10,391,874 		JBrowse link
G LAG3 lymphocyte activating 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8602528) Ensembl
MGI		 PMID:8602528 GO_REF:0000107 NCBI chr12:6,772,520...6,778,455
Ensembl chr12:6,772,512...6,778,455 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IMP (PMID:23632890) UniProt PMID:23632890 NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672 		JBrowse link
G NCR3 natural cytotoxicity triggering receptor 3 involved_in IEA
IBA
IMP		 (PMID:16304049) InterPro
GO_Central
BHF-UCL		 PMID:16304049 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:31,588,895...31,593,006
Ensembl chr 6:31,588,895...31,593,006 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in IMP (PMID:16304049) BHF-UCL PMID:16304049 NCBI chr19:44,846,297...44,889,223
Ensembl chr19:44,846,175...44,889,223 		JBrowse link
G PVR PVR cell adhesion molecule involved_in IMP (PMID:16304049) BHF-UCL PMID:16304049 NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162 		JBrowse link
G RAET1E retinoic acid early transcript 1E involved_in IDA (PMID:18544572) UniProt PMID:18544572 NCBI chr 6:149,883,179...149,898,113
Ensembl chr 6:149,883,179...149,898,113 		JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in IMP (PMID:19933860) UniProt PMID:19933860 NCBI chr15:38,488,103...38,564,814
Ensembl chr15:38,488,103...38,565,575 		JBrowse link
G SH2D1A SH2 domain containing 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19648922)
(PMID:16127454)		 Ensembl
MGI		 PMID:16127454 PMID:19648922 GO_REF:0000107 NCBI chr  X:124,346,563...124,373,160
Ensembl chr  X:124,227,868...124,373,197 		JBrowse link
G SH2D1B SH2 domain containing 1B acts_upstream_of_or_within ISO (PMID:19648922)
(PMID:20962259)		 MGI PMID:19648922 PMID:20962259 NCBI chr 1:162,395,268...162,412,136
Ensembl chr 1:162,395,268...162,412,138 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in IDA (PMID:16920955) UniProt PMID:16920955 NCBI chr 1:160,485,036...160,523,255
Ensembl chr 1:160,485,030...160,523,262 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:9841920) MGI PMID:9841920 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9841920) Ensembl
MGI		 PMID:9841920 GO_REF:0000107 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633 		JBrowse link
G VAV1 vav guanine nucleotide exchange factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20962259) Ensembl
MGI		 PMID:20962259 GO_REF:0000107 NCBI chr19:6,772,708...6,857,361
Ensembl chr19:6,772,708...6,857,366 		JBrowse link
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD226 CD226 molecule involved_in IMP (PMID:12913096) BHF-UCL PMID:12913096 NCBI chr18:69,853,274...69,961,773
Ensembl chr18:69,831,158...69,961,803 		JBrowse link
G CRTAM cytotoxic and regulatory T cell molecule involved_in IDA
IEA
IBA		 (PMID:15811952) HGNC-UCL
TreeGrafter
GO_Central
Ensembl		 PMID:15811952 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:122,838,500...122,872,643
Ensembl chr11:122,838,500...122,872,643 		JBrowse link
G IL12A interleukin 12A involved_in IDA (PMID:7903063) UniProt PMID:7903063 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B involved_in IDA (PMID:7903063) UniProt PMID:7903063 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 ISO RGD PMID:16323246 RGD:9685180 NCBI chr12:10,372,353...10,390,041
Ensembl chr12:10,372,353...10,391,874 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in IMP
IEA
IBA		 (PMID:12913096) BHF-UCL
TreeGrafter
GO_Central		 PMID:12913096 GO_REF:0000033 GO_REF:0000118 NCBI chr19:44,846,297...44,889,223
Ensembl chr19:44,846,175...44,889,223 		JBrowse link
G PVR PVR cell adhesion molecule involved_in IMP (PMID:12913096) BHF-UCL PMID:12913096 NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162 		JBrowse link
positive regulation of neutrophil mediated killing of fungus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG1 arginase 1 involved_in IMP (PMID:15546957) UniProt PMID:15546957 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 involved_in ISO (MGI:5586806|PMID:10725737) UniProt PMID:10725737 MGI:5586806 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G POMC proopiomelanocortin involved_in IDA (PMID:10670585) UniProt PMID:10670585 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
positive regulation of neutrophil mediated killing of gram-negative bacterium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL1 F2R like trypsin receptor 1 involved_in IDA (PMID:21501162) UniProt PMID:21501162 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315 		JBrowse link
positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16299293) Ensembl
MGI		 PMID:16299293 GO_REF:0000107 NCBI chr15:44,711,517...44,718,145
Ensembl chr15:44,711,358...44,718,851 		JBrowse link
G CD1A CD1a molecule involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:158,248,336...158,258,269
Ensembl chr 1:158,254,424...158,258,269 		JBrowse link
G CD1B CD1b molecule involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:158,285,405...158,331,531
Ensembl chr 1:158,327,951...158,331,531 		JBrowse link
G CD1C CD1c molecule involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:158,289,923...158,294,774
Ensembl chr 1:158,289,923...158,294,774 		JBrowse link
G CD1D CD1d molecule involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:10201995) GO_Central
MGI		 PMID:10201995 GO_REF:0000033 NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427 		JBrowse link
G CD1E CD1e molecule involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:158,353,894...158,357,553
Ensembl chr 1:158,353,696...158,357,553 		JBrowse link
G CYRIB CYFIP related Rac1 interactor B involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:129,839,593...130,017,129
Ensembl chr 8:129,839,593...130,017,504 		JBrowse link
G FADD Fas associated via death domain involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G HFE homeostatic iron regulator involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:26,087,429...26,098,343
Ensembl chr 6:26,087,226...26,098,343 		JBrowse link
G HLA-A major histocompatibility complex, class I, A involved_in IDA
IEA
IBA		 (PMID:22031944), (PMID:2420472), (PMID:25631937), (PMID:8805302) UniProt
TreeGrafter
GO_Central		 PMID:2420472 PMID:8805302 PMID:22031944 PMID:25631937 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,949,572 		JBrowse link
G HLA-B major histocompatibility complex, class I, B involved_in IDA
IEA
IBA		 (PMID:2420472) UniProt
TreeGrafter
GO_Central		 PMID:2420472 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067 		JBrowse link
G HLA-C major histocompatibility complex, class I, C involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:31,268,749...31,272,092
Ensembl chr 6:31,268,749...31,272,130 		JBrowse link
G HLA-DPB1 major histocompatibility complex, class II, DP beta 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,936...33,089,696 		JBrowse link
G HLA-DRA major histocompatibility complex, class II, DR alpha involved_in IDA (PMID:29884618) UniProt PMID:29884618 NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046 		JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 involved_in IDA
IEA		 (PMID:29884618) UniProt
TreeGrafter		 PMID:29884618 GO_REF:0000118 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848 		JBrowse link
G HLA-E major histocompatibility complex, class I, E involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO
IBA		 (PMID:20195504), (PMID:25631937)
(PMID:1538753)		 UniProt
TreeGrafter
MGI
GO_Central		 PMID:1538753 PMID:20195504 PMID:25631937 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
G HLA-F major histocompatibility complex, class I, F involved_in IMP
IBA		 (PMID:23851683) UniProt
GO_Central		 PMID:23851683 GO_REF:0000033 NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528 		JBrowse link
G HLA-G major histocompatibility complex, class I, G involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:16299293), (PMID:16461341), (PMID:16476767), (PMID:8464890)
(PMID:16476767)		 GO_Central
TreeGrafter
MGI		 PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G HLA-H major histocompatibility complex, class I, H (pseudogene) involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:29,887,573...29,891,079
Ensembl chr 6:29,887,752...29,890,482 		JBrowse link
G HLA-L major histocompatibility complex, class I, L (pseudogene) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:30,259,562...30,266,951
Ensembl chr 6:30,259,548...30,293,015
Ensembl chr 6:30,259,548...30,293,015 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B ISO prevention of heat shock-induced resistance to CTL-mediated killing RGD PMID:10679071 RGD:1298959 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 involved_in ISO
IEA		 RGD
Ensembl		 PMID:8871636 GO_REF:0000107 RGD:10059395 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230 		JBrowse link
G IL12A interleukin 12A involved_in IDA (PMID:1674604), (PMID:2204066) UniProt PMID:1674604 PMID:2204066 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL12RB1 interleukin 12 receptor subunit beta 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr19:18,058,995...18,098,816
Ensembl chr19:18,058,995...18,098,944 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL23R interleukin 23 receptor involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979 		JBrowse link
G MICA MHC class I polypeptide-related sequence A involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:31,400,711...31,415,315
Ensembl chr 6:31,399,784...31,415,315 		JBrowse link
G MICB MHC class I polypeptide-related sequence B involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:31,494,918...31,511,124
Ensembl chr 6:31,494,881...31,511,124 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14761980) Ensembl
MGI		 PMID:14761980 GO_REF:0000107 NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:6233370) Ensembl
MGI		 PMID:6233370 GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,757,476 		JBrowse link
G RAET1E retinoic acid early transcript 1E involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:149,883,179...149,898,113
Ensembl chr 6:149,883,179...149,898,113 		JBrowse link
G RAET1G retinoic acid early transcript 1G involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:149,916,878...149,923,121
Ensembl chr 6:149,916,878...149,923,121 		JBrowse link
G RAET1L retinoic acid early transcript 1L involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:150,018,334...150,025,532
Ensembl chr 6:150,018,334...150,025,532 		JBrowse link
G STX7 syntaxin 7 involved_in IMP (PMID:21438968) UniProt PMID:21438968 NCBI chr 6:132,445,867...132,513,472
Ensembl chr 6:132,445,867...132,513,198 		JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member acts_upstream_of_or_within
involved_in		 ISO
IEA		 PMID:1758495
(PMID:16299293)
(PMID:1538753)		 MGI
Ensembl		 PMID:1538753 PMID:1758495 PMID:16299293 GO_REF:0000107 RGD:1299069 NCBI chr 6:32,821,831...32,838,739
Ensembl chr 6:32,821,833...32,838,739 		JBrowse link
G ULBP1 UL16 binding protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:149,963,943...149,973,715
Ensembl chr 6:149,963,943...149,973,715 		JBrowse link
G ULBP2 UL16 binding protein 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:149,942,014...149,949,235
Ensembl chr 6:149,942,014...149,949,235 		JBrowse link
G ULBP3 UL16 binding protein 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:150,061,053...150,069,121
Ensembl chr 6:150,061,053...150,069,121 		JBrowse link
G XCL1 X-C motif chemokine ligand 1 involved_in IDA (PMID:18832695) BHF-UCL PMID:18832695 NCBI chr 1:168,576,605...168,582,069
Ensembl chr 1:168,576,605...168,582,069 		JBrowse link
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MR1 major histocompatibility complex, class I-related involved_in IDA (PMID:31959982) UniProt PMID:31959982 NCBI chr 1:181,033,387...181,061,938
Ensembl chr 1:181,033,374...181,061,938 		JBrowse link
G SLC22A13 solute carrier family 22 member 13 involved_in IDA (PMID:19282870) UniProt PMID:19282870 NCBI chr 3:38,265,812...38,278,757
Ensembl chr 3:38,265,812...38,278,757 		JBrowse link
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HLA-A major histocompatibility complex, class I, A involved_in
NOT|involved_in		 IDA (PMID:18502829), (PMID:8839770) UniProt PMID:8839770 PMID:18502829 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,949,572 		JBrowse link
G HLA-B major histocompatibility complex, class I, B involved_in IDA (PMID:18502829), (PMID:2784569), (PMID:8046333) UniProt PMID:2784569 PMID:8046333 PMID:18502829 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067 		JBrowse link
G HLA-E major histocompatibility complex, class I, E involved_in IDA (PMID:25631937), (PMID:9754572) UniProt PMID:9754572 PMID:25631937 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
G HLA-G major histocompatibility complex, class I, G involved_in IDA (PMID:11290782) UniProt PMID:11290782 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G SERPINB4 serpin family B member 4 involved_in IMP (PMID:21857942) UniProt PMID:21857942 NCBI chr18:63,637,259...63,644,256
Ensembl chr18:63,637,259...63,644,256 		JBrowse link
G SERPINB9 serpin family B member 9 involved_in IMP (PMID:21795594) UniProt PMID:21795594 NCBI chr 6:2,887,270...2,903,309
Ensembl chr 6:2,887,270...2,903,309 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member ISO RGD PMID:8120379 RGD:2312378 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816 		JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member ISO RGD PMID:8120379 RGD:2312378 NCBI chr 6:32,821,831...32,838,739
Ensembl chr 6:32,821,833...32,838,739 		JBrowse link
regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FCGR2A Fc gamma receptor IIa ISO RGD PMID:16482158 RGD:2293335 NCBI chr 1:161,505,457...161,524,048
Ensembl chr 1:161,505,430...161,524,013 		JBrowse link
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KLRB1 killer cell lectin like receptor B1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:9,594,551...9,607,916
Ensembl chr12:9,594,551...9,607,916 		JBrowse link
G LEP leptin involved_in IDA (PMID:12504075) UniProt PMID:12504075 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 involved_in TAS (PMID:15654827) UniProt PMID:15654827 NCBI chr19:54,898,198...54,938,208
Ensembl chr19:54,906,148...54,916,140 		JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 involved_in IDA (PMID:11062502) CACAO PMID:11062502 NCBI chr17:8,802,722...8,867,677
Ensembl chr17:8,802,722...8,867,677 		JBrowse link
regulation of neutrophil mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNASE1 deoxyribonuclease 1 involved_in IEA
ISS		 (PMID:29191910) Ensembl
UniProt		 PMID:29191910 GO_REF:0000107 NCBI chr16:3,611,760...3,665,461
Ensembl chr16:3,611,728...3,680,143 		JBrowse link
G DNASE1L3 deoxyribonuclease 1L3 involved_in IEA
ISS		 (PMID:29191910) Ensembl
UniProt		 PMID:29191910 GO_REF:0000107 NCBI chr 3:58,192,257...58,210,972
Ensembl chr 3:58,192,257...58,214,697 		JBrowse link
regulation of neutrophil mediated killing of gram-negative bacterium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL6 C-X-C motif chemokine ligand 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20643340) Ensembl
MGI		 PMID:20643340 GO_REF:0000107 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064 		JBrowse link
regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor involved_in IDA (PMID:22473704) UniProt PMID:22473704 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:24,336,025...24,339,991
Ensembl chr14:24,336,025...24,340,022 		JBrowse link
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADM1 cell adhesion molecule 1 involved_in IDA
IEA
IBA
ISS		 (PMID:15811952)
(PMID:12826663)		 UniProt
TreeGrafter
GO_Central		 PMID:12826663 PMID:15811952 GO_REF:0000033 GO_REF:0000118 NCBI chr11:115,169,236...115,504,415
Ensembl chr11:115,169,218...115,504,957 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in IMP
IEA		 (PMID:12913096) BHF-UCL
TreeGrafter		 PMID:12913096 GO_REF:0000118 NCBI chr19:44,846,297...44,889,223
Ensembl chr19:44,846,175...44,889,223 		JBrowse link
G PVR PVR cell adhesion molecule involved_in IMP (PMID:12913096) BHF-UCL PMID:12913096 NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162 		JBrowse link
G ULBP1 UL16 binding protein 1 acts_upstream_of_or_within ISO (PMID:12645935) MGI PMID:12645935 NCBI chr 6:149,963,943...149,973,715
Ensembl chr 6:149,963,943...149,973,715 		JBrowse link
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECTIN2 nectin cell adhesion molecule 2 involved_in IDA
IEA		 (PMID:15039383) BHF-UCL
TreeGrafter		 PMID:15039383 GO_REF:0000118 NCBI chr19:44,846,297...44,889,223
Ensembl chr19:44,846,175...44,889,223 		JBrowse link
G PVR PVR cell adhesion molecule involved_in IDA (PMID:15039383) BHF-UCL PMID:15039383 NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19654
    cellular process 18268
      regulation of cellular process 12419
        regulation of cell killing 136
          regulation of leukocyte mediated cytotoxicity 111
            negative regulation of leukocyte mediated cytotoxicity + 32
            positive regulation of leukocyte mediated cytotoxicity + 80
            regulation of T cell mediated cytotoxicity + 55
            regulation of antibody-dependent cellular cytotoxicity + 3
            regulation of microglial cell mediated cytotoxicity + 5
            regulation of natural killer cell mediated cytotoxicity + 57
            regulation of neutrophil mediated cytotoxicity + 7
Path 2
Term Annotations click to browse term
  biological_process 19654
    biological regulation 13379
      regulation of biological process 12994
        regulation of immune system process 1825
          regulation of immune effector process 467
            regulation of leukocyte mediated immunity 293
              regulation of leukocyte mediated cytotoxicity 111
                negative regulation of leukocyte mediated cytotoxicity + 32
                positive regulation of leukocyte mediated cytotoxicity + 80
                regulation of T cell mediated cytotoxicity + 55
                regulation of antibody-dependent cellular cytotoxicity + 3
                regulation of microglial cell mediated cytotoxicity + 5
                regulation of natural killer cell mediated cytotoxicity + 57
                regulation of neutrophil mediated cytotoxicity + 7
paths to the root