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Gene: TYROBP (transmembrane immune signaling adaptor TYROBP) Homo sapiens
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Symbol: TYROBP
Name: transmembrane immune signaling adaptor TYROBP
Description: Exhibits identical protein binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of B cell proliferation; positive regulation of macrophage fusion; and positive regulation of protein localization to cell surface. Localizes to the cell surface. Implicated in Nasu-Hakola disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DAP12; DNAX adaptor protein 12; DNAX-activation protein 12; KAR-associated protein; KARAP; killer activating receptor associated protein; killer-activating receptor-associated protein; PLOSL; PLOSL1; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy; TYRO protein tyrosine kinase-binding protein
Orthologs:
Mus musculus (house mouse) : Tyrobp (TYRO protein tyrosine kinase binding protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tyrobp (transmembrane immune signaling adaptor Tyrobp)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Pan paniscus (bonobo/pygmy chimpanzee) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Canis lupus familiaris (dog) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Sus scrofa (pig) : TYROBP (transmembrane immune signaling adaptor TYROBP)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,904,403 - 35,908,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371936,395,303 - 36,399,211 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,087,143 - 41,091,026 (-)NCBINCBI36hg18NCBI36
Build 341941,087,143 - 41,091,026NCBI
Celera1933,109,494 - 33,113,402 (-)NCBI
Cytogenetic Map19q13.12NCBI
HuRef1932,900,548 - 32,904,456 (-)NCBIHuRef
CHM1_11936,396,596 - 36,400,504 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TYROBP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351113
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.