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Gene: TYROBP (transmembrane immune signaling adaptor TYROBP) Homo sapiens
Symbol: TYROBP
Name: transmembrane immune signaling adaptor TYROBP
Description: Exhibits identical protein binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of B cell proliferation; positive regulation of macrophage fusion; and positive regulation of protein localization to cell surface. Localizes to the cell surface. Implicated in Nasu-Hakola disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DAP12; DNAX adaptor protein 12; DNAX-activation protein 12; KAR-associated protein; KARAP; killer activating receptor associated protein; killer-activating receptor-associated protein; PLOSL; PLOSL1; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy; TYRO protein tyrosine kinase-binding protein
Mus musculus (house mouse) : Tyrobp (TYRO protein tyrosine kinase binding protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tyrobp (transmembrane immune signaling adaptor Tyrobp)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Pan paniscus (bonobo/pygmy chimpanzee) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Canis lupus familiaris (dog) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Sus scrofa (pig) : TYROBP (transmembrane immune signaling adaptor TYROBP)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381935,904,403 - 35,908,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371936,395,303 - 36,399,211 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,087,143 - 41,091,026 (-)NCBINCBI36hg18NCBI36
Build 341941,087,143 - 41,091,026NCBI
Celera1933,109,494 - 33,113,402 (-)NCBI
Cytogenetic Map19q13.12NCBI
HuRef1932,900,548 - 32,904,456 (-)NCBIHuRef
CHM1_11936,396,596 - 36,400,504 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TYROBP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351113
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.