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Gene: P2RX7 (purinergic receptor P2X 7) Homo sapiens
Symbol: P2RX7
Name: purinergic receptor P2X 7
Description: Exhibits extracellularly ATP-gated cation channel activity and purinergic nucleotide receptor activity. Involved in several processes, including bleb assembly; negative regulation of cell volume; and positive regulation of transport. Localizes to the plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP receptor; MGC20089; P2X purinoceptor 7; P2X7; P2X7 receptor; P2Z receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A; purnergic receptor P2X 7
Mus musculus (house mouse) : P2rx7 (purinergic receptor P2X, ligand-gated ion channel, 7)  MGI  Alliance
Rattus norvegicus (Norway rat) : P2rx7 (purinergic receptor P2X 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2rx7 (purinergic receptor P2X 7)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RX7 (purinergic receptor P2X 7)
Canis lupus familiaris (dog) : P2RX7 (purinergic receptor P2X 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2rx7 (purinergic receptor P2X 7)
Sus scrofa (pig) : P2RX7 (purinergic receptor P2X 7)
Chlorocebus sabaeus (African green monkey) : P2RX7 (purinergic receptor P2X 7)
Heterocephalus glaber (naked mole-rat) : P2rx7 (purinergic receptor P2X 7)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12121,132,819 - 121,188,032 (+)Ensembl
GRCh3812121,132,819 - 121,188,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712121,570,622 - 121,624,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,055,061 - 120,108,259 (+)NCBINCBI36hg18NCBI36
Build 3412120,033,397 - 120,086,591NCBI
Celera12121,208,365 - 121,262,089 (+)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12118,580,277 - 118,634,021 (+)NCBIHuRef
CHM1_112121,539,497 - 121,593,180 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on P2RX7
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730814
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.