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Gene: HLA-F (major histocompatibility complex, class I, F) Homo sapiens
Symbol: HLA-F
Name: major histocompatibility complex, class I, F
Description: Exhibits several functions, including 14-3-3 protein binding activity; TAP binding activity; and beta-2-microglobulin binding activity. Involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class Ib; antigen processing and presentation of exogenous peptide antigen via MHC class Ib; and regulation of lymphocyte mediated immunity. Localizes to several cellular components, including MHC class Ib protein complex; bounding membrane of organelle; and cell surface.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDA12; HLA class I histocompatibility antigen, alpha chain F; HLA class I molecule; HLA F antigen; HLA-5.4; HLA-CDA12; HLAF; leukocyte antigen F; MHC class I antigen; MHC class I antigen F; MHC class Ib antigen
Rattus norvegicus (Norway rat) : RT1-CE5 (RT1 class I, locus CE5)  Alliance
Canis lupus familiaris (dog) : DLA-79 (MHC class Ib)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl629,722,775 - 29,738,528 (+)EnsemblGRCh38hg38GRCh38
GRCh38629,723,340 - 29,740,355 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37629,691,117 - 29,695,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,799,096 - 29,803,052 (+)NCBINCBI36hg18NCBI36
Build 34629,799,219 - 29,802,262NCBI
Celera631,294,546 - 31,298,502 (+)NCBI
Cytogenetic Map6p22.1NCBI
HuRef629,494,781 - 29,498,733 (+)NCBIHuRef
CHM1_1629,693,239 - 29,697,195 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HLA-F
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345133
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-04-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.