KLRC4 (killer cell lectin like receptor C4) - Rat Genome Database

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Gene: KLRC4 (killer cell lectin like receptor C4) Homo sapiens
Analyze
Symbol: KLRC4
Name: killer cell lectin like receptor C4
RGD ID: 1342769
HGNC Page HGNC:6377
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of natural killer cell mediated cytotoxicity and stimulatory C-type lectin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ17759; FLJ78582; killer cell lectin-like receptor subfamily C, member 4; natual killer cell group 2-F; NK cell receptor F; NKG2-F; NKG2-F type II integral membrane protein; NKG2-F-activating NK receptor; NKG2F
RGD Orthologs
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,407,384 - 10,409,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,403,059 - 10,409,757 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,559,983 - 10,562,356 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,451,250 - 10,453,623 (-)NCBINCBI36Build 36hg18NCBI36
Build 341210,451,249 - 10,453,623NCBI
Celera1215,721,849 - 15,724,222 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,302,410 - 10,304,783 (-)NCBIHuRef
CHM1_11210,529,417 - 10,531,790 (-)NCBICHM1_1
T2T-CHM13v2.01210,294,201 - 10,296,574 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
AA amyloidosis  (IAGP)
Abdominal pain  (IAGP)
Abnormal blistering of the skin  (IAGP)
Abnormal myocardium morphology  (IAGP)
Abnormal pyramidal sign  (IAGP)
Acne  (IAGP)
Anorexia  (IAGP)
Aortic regurgitation  (IAGP)
Arterial thrombosis  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Ataxia  (IAGP)
Atypical behavior  (IAGP)
Avascular necrosis  (IAGP)
Blindness  (IAGP)
Cataract  (IAGP)
Cerebral ischemia  (IAGP)
Confusion  (IAGP)
Cranial nerve paralysis  (IAGP)
Developmental regression  (IAGP)
Diarrhea  (IAGP)
Elevated circulating C-reactive protein concentration  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Endocarditis  (IAGP)
Epididymitis  (IAGP)
Erythema nodosum  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Gait disturbance  (IAGP)
Gangrene  (IAGP)
Gastrointestinal hemorrhage  (IAGP)
Genital ulcers  (IAGP)
Glomerulonephritis  (IAGP)
Glomerulopathy  (IAGP)
Headache  (IAGP)
Hemiparesis  (IAGP)
Hemoptysis  (IAGP)
Hyperreflexia  (IAGP)
Immunologic hypersensitivity  (IAGP)
Increased inflammatory response  (IAGP)
Increased intracranial pressure  (IAGP)
Infectious encephalitis  (IAGP)
Irritability  (IAGP)
Keratoconjunctivitis sicca  (IAGP)
Lymphadenopathy  (IAGP)
Malabsorption  (IAGP)
Memory impairment  (IAGP)
Meningitis  (IAGP)
Migraine  (IAGP)
Mitral regurgitation  (IAGP)
Myalgia  (IAGP)
Myocardial infarction  (IAGP)
Myocarditis  (IAGP)
Myositis  (IAGP)
Nausea and vomiting  (IAGP)
Non-infectious meningitis  (IAGP)
Nongranulomatous uveitis  (IAGP)
Optic neuritis  (IAGP)
Oral ulcer  (IAGP)
Orchitis  (IAGP)
Pancreatitis  (IAGP)
Panuveitis  (IAGP)
Papule  (IAGP)
Paresthesia  (IAGP)
Pericarditis  (IAGP)
Photophobia  (IAGP)
Pleural effusion  (IAGP)
Pleuritis  (IAGP)
Positive pathergy test  (IAGP)
Pulmonary embolism  (IAGP)
Pulmonary infiltrates  (IAGP)
Pustule  (IAGP)
Recurrent aphthous stomatitis  (IAGP)
Recurrent fever  (IAGP)
Renal insufficiency  (IAGP)
Retinopathy  (IAGP)
Retrobulbar optic neuritis  (IAGP)
Seizure  (IAGP)
Splenomegaly  (IAGP)
Subcutaneous nodule  (IAGP)
Superficial thrombophlebitis  (IAGP)
Vasculitis  (IAGP)
Venous thrombosis  (IAGP)
Vertigo  (IAGP)
Weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8436421   PMID:9394807   PMID:9598306   PMID:9683661   PMID:9887346   PMID:10783260   PMID:11751968   PMID:12477932   PMID:15140575   PMID:15489334   PMID:16397273   PMID:18006695  
PMID:20237496   PMID:20648603   PMID:20654155   PMID:20811687   PMID:21873635   PMID:23291587   PMID:26097239   PMID:28706259   PMID:30021884   PMID:31502863   PMID:33961781   PMID:35013218  
PMID:38113892   PMID:38237612  


Genomics

Comparative Map Data
KLRC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,407,384 - 10,409,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,403,059 - 10,409,757 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,559,983 - 10,562,356 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,451,250 - 10,453,623 (-)NCBINCBI36Build 36hg18NCBI36
Build 341210,451,249 - 10,453,623NCBI
Celera1215,721,849 - 15,724,222 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,302,410 - 10,304,783 (-)NCBIHuRef
CHM1_11210,529,417 - 10,531,790 (-)NCBICHM1_1
T2T-CHM13v2.01210,294,201 - 10,296,574 (-)NCBIT2T-CHM13v2.0
KLRC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,861,775 - 15,892,069 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,858,532 - 15,888,826 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01210,418,672 - 10,449,250 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,669,493 - 10,699,818 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,697,454 - 10,699,818 (-)Ensemblpanpan1.1panPan2
LOC100683403
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12735,307,892 - 35,374,397 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2711,194,081 - 11,220,221 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02735,654,481 - 35,726,775 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12735,538,140 - 35,606,718 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02735,578,454 - 35,636,153 (+)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.02735,484,257 - 35,530,625 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,772,959 - 10,835,787 (-)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in KLRC4
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.2(chr12:10273008-10633696)x1 copy number loss See cases [RCV000135370] Chr12:10273008..10633696 [GRCh38]
Chr12:10425607..10786295 [GRCh37]
Chr12:10316874..10677562 [NCBI36]
Chr12:12p13.2		 uncertain significance
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
chr12:10074776-18800953 complex variant complex Breast ductal adenocarcinoma [RCV000207105] Chr12:10074776..18800953 [GRCh37]
Chr12:12p13.31-12.3		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1		 likely pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3 copy number gain See cases [RCV000510853] Chr12:173786..11677456 [GRCh37]
Chr12:12p13.33-13.2		 pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.2-13.1(chr12:10336209-13535349) copy number loss Multiple endocrine neoplasia type 4 [RCV000767604] Chr12:10336209..13535349 [GRCh37]
Chr12:12p13.2-13.1		 pathogenic
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_013431.2(KLRC4):c.85A>G (p.Ile29Val) single nucleotide variant not specified [RCV004317895] Chr12:10409491 [GRCh38]
Chr12:10562090 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_001199805.1(KLRC4-KLRK1):c.-364A>G single nucleotide variant not provided [RCV001679097] Chr12:10408358 [GRCh38]
Chr12:10560957 [GRCh37]
Chr12:12p13.2		 benign
NM_013431.2(KLRC4):c.344G>A (p.Arg115His) single nucleotide variant not specified [RCV004289427] Chr12:10407786 [GRCh38]
Chr12:10560385 [GRCh37]
Chr12:12p13.2		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837) copy number gain not specified [RCV002052957] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865) copy number gain not specified [RCV002052955] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301) copy number gain not specified [RCV002052958] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
NM_013431.2(KLRC4):c.205G>C (p.Glu69Gln) single nucleotide variant not specified [RCV004169661] Chr12:10408993 [GRCh38]
Chr12:10561592 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_013431.2(KLRC4):c.407A>G (p.Lys136Arg) single nucleotide variant not specified [RCV004131377] Chr12:10407723 [GRCh38]
Chr12:10560322 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_013431.2(KLRC4):c.188G>T (p.Gly63Val) single nucleotide variant not specified [RCV004135390] Chr12:10409010 [GRCh38]
Chr12:10561609 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_013431.2(KLRC4):c.119A>G (p.Gln40Arg) single nucleotide variant not specified [RCV004168770] Chr12:10409457 [GRCh38]
Chr12:10562056 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_013431.2(KLRC4):c.65G>C (p.Arg22Thr) single nucleotide variant not specified [RCV004172582] Chr12:10409511 [GRCh38]
Chr12:10562110 [GRCh37]
Chr12:12p13.2		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:176047-34179852)x4 copy number gain Pallister-Killian syndrome [RCV003154827] Chr12:176047..34179852 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_013431.2(KLRC4):c.217G>A (p.Ala73Thr) single nucleotide variant not specified [RCV004267865] Chr12:10408981 [GRCh38]
Chr12:10561580 [GRCh37]
Chr12:12p13.2		 uncertain significance
Single allele duplication not provided [RCV003448692] Chr12:188053..34856694 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835641)x3 copy number gain not specified [RCV003986979] Chr12:173786..34835641 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_013431.2(KLRC4):c.299T>A (p.Leu100Gln) single nucleotide variant not specified [RCV004409720] Chr12:10408370 [GRCh38]
Chr12:10560969 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_013431.2(KLRC4):c.38T>G (p.Leu13Arg) single nucleotide variant not specified [RCV004409721] Chr12:10409538 [GRCh38]
Chr12:10562137 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_013431.2(KLRC4):c.458C>G (p.Thr153Ser) single nucleotide variant not specified [RCV004409722] Chr12:10407672 [GRCh38]
Chr12:10560271 [GRCh37]
Chr12:12p13.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:61
Interacting mature miRNAs:64
Transcripts:ENST00000309384
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407250695GWAS899671_Hserum non-albumin protein measurement QTL GWAS899671 (human)1e-15serum non-albumin protein measurementserum globulin level (CMO:0002399)121040835810408359Human
407078673GWAS727649_Hblood protein measurement QTL GWAS727649 (human)9e-73blood protein measurementblood protein measurement (CMO:0000028)121040835810408359Human
407252293GWAS901269_Haspartate aminotransferase measurement QTL GWAS901269 (human)4e-16aspartate aminotransferase measurementblood aspartate aminotransferase activity level (CMO:0000580)121040835810408359Human
407027510GWAS676486_HBehcet's syndrome QTL GWAS676486 (human)1e-09Behcet's syndrome121040835810408359Human

Markers in Region
G42648  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371210,561,445 - 10,561,563UniSTSGRCh37
Build 361210,452,712 - 10,452,830RGDNCBI36
Celera1215,723,311 - 15,723,429RGD
Cytogenetic Map12p13.2-p12.3UniSTS
HuRef1210,303,872 - 10,303,990UniSTS
G17638  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371210,561,451 - 10,561,563UniSTSGRCh37
Build 361210,452,718 - 10,452,830RGDNCBI36
Celera1215,723,317 - 15,723,429RGD
Cytogenetic Map12p13.2-p12.3UniSTS
HuRef1210,303,878 - 10,303,990UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1198 2264 2391 1942 4497 1573 2065 3 530 1435 370 1945 5872 5576 25 3583 665 1538 1442 164

Sequence


Ensembl Acc Id: ENST00000309384   ⟹   ENSP00000310216
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1210,407,384 - 10,409,757 (-)Ensembl
Ensembl Acc Id: ENST00000718241   ⟹   ENSP00000520686
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1210,403,059 - 10,409,757 (-)Ensembl
Ensembl Acc Id: ENST00000718242   ⟹   ENSP00000520687
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1210,404,484 - 10,409,597 (-)Ensembl
RefSeq Acc Id: NM_013431   ⟹   NP_038459
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381210,407,384 - 10,409,757 (-)NCBI
GRCh371210,541,529 - 10,562,370 (-)NCBI
Build 361210,451,250 - 10,453,623 (-)NCBI Archive
HuRef1210,302,410 - 10,304,783 (-)ENTREZGENE
CHM1_11210,529,417 - 10,531,790 (-)NCBI
T2T-CHM13v2.01210,294,201 - 10,296,574 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038459   ⟸   NM_013431
- UniProtKB: O60851 (UniProtKB/Swiss-Prot),   O43908 (UniProtKB/Swiss-Prot),   H3BQV0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000310216   ⟸   ENST00000309384
Ensembl Acc Id: ENSP00000520687   ⟸   ENST00000718242
Ensembl Acc Id: ENSP00000520686   ⟸   ENST00000718241

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O43908-F1-model_v2 AlphaFold O43908 1-158 view protein structure

Promoters
RGD ID:7223175
Promoter ID:EPDNEW_H17333
Type:initiation region
Name:KLRC4_1
Description:killer cell lectin like receptor C4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381210,409,549 - 10,409,609EPDNEW
RGD ID:6790175
Promoter ID:HG_KWN:15024
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000396451,   NM_013431,   UC001QYD.1,   UC009ZHK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361210,454,536 - 10,455,036 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6377 AgrOrtholog
COSMIC KLRC4 COSMIC
Ensembl Genes ENSG00000183542 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000309384 ENTREZGENE
  ENST00000309384.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
  YojJ-like UniProtKB/Swiss-Prot
GTEx ENSG00000183542 GTEx
HGNC ID HGNC:6377 ENTREZGENE
Human Proteome Map KLRC4 Human Proteome Map
InterPro C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  NKG2/CD94_NK_receptors UniProtKB/Swiss-Prot
KEGG Report hsa:8302 UniProtKB/Swiss-Prot
NCBI Gene 8302 ENTREZGENE
OMIM 602893 OMIM
PANTHER C-TYPE LECTIN PROTEINS UniProtKB/Swiss-Prot
  NKG2-F TYPE II INTEGRAL MEMBRANE PROTEIN UniProtKB/Swiss-Prot
PharmGKB PA30166 PharmGKB
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt H3BQV0 ENTREZGENE
  NKG2F_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  O60851 ENTREZGENE
UniProt Secondary O60851 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 KLRC4  killer cell lectin like receptor C4    killer cell lectin-like receptor subfamily C, member 4  Symbol and/or name change 5135510 APPROVED