KLRC4-KLRK1 (KLRC4-KLRK1 readthrough) - Rat Genome Database

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Gene: KLRC4-KLRK1 (KLRC4-KLRK1 readthrough) Homo sapiens
Analyze
Symbol: KLRC4-KLRK1
Name: KLRC4-KLRK1 readthrough
RGD ID: 7380820
HGNC Page HGNC
Description: Enables signaling receptor activity. Involved in several processes, including negative regulation of GTPase activity; negative regulation of natural killer cell chemotaxis; and positive regulation of natural killer cell mediated cytotoxicity. Located in cell surface and plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor
RGD Orthologs
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1210,372,353 - 10,410,146 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1210,372,353 - 10,391,874 (-)EnsemblGRCh38hg38GRCh38
GRCh381210,372,353 - 10,410,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371210,524,952 - 10,562,745 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12p13.2NCBI
HuRef1210,267,379 - 10,305,170 (-)NCBIHuRef
CHM1_11210,494,385 - 10,532,177 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:2007850   PMID:8436421   PMID:9598306   PMID:9683661   PMID:9887346   PMID:10426993   PMID:10426994   PMID:10783260   PMID:11323699   PMID:11751968   PMID:11754823   PMID:11973127  
PMID:12679019   PMID:14702039   PMID:15240696   PMID:15294961   PMID:15489334   PMID:16444266   PMID:16541075   PMID:17562706   PMID:18544572   PMID:18676862   PMID:19424970   PMID:19436053  
PMID:19658097   PMID:20967262   PMID:21712812   PMID:21873635   PMID:22585739   PMID:23291587   PMID:23696226   PMID:28559451   PMID:32296183  


Genomics

Comparative Map Data
KLRC4-KLRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1210,372,353 - 10,410,146 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1210,372,353 - 10,391,874 (-)EnsemblGRCh38hg38GRCh38
GRCh381210,372,353 - 10,410,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371210,524,952 - 10,562,745 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12p13.2NCBI
HuRef1210,267,379 - 10,305,170 (-)NCBIHuRef
CHM1_11210,494,385 - 10,532,177 (-)NCBICHM1_1
Clec2m
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,299,128 - 129,308,770 (-)NCBIGRCm39mm39
GRCm39 Ensembl6129,299,127 - 129,308,759 (-)Ensembl
GRCm386129,322,165 - 129,331,807 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,322,164 - 129,331,796 (-)EnsemblGRCm38mm10GRCm38
MGSCv376129,272,183 - 129,281,799 (-)NCBIGRCm37mm9NCBIm37
MGSCv366129,287,857 - 129,297,446 (-)NCBImm8
Celera6131,044,514 - 131,054,123 (-)NCBICelera
Cytogenetic Map6F3NCBI
Klre1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24163,032,938 - 163,041,641 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4163,033,563 - 163,041,638 (+)Ensembl
Rnor_6.04163,346,684 - 163,355,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,349,125 - 163,354,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,989,389 - 211,997,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,857,685 - 166,864,221 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14167,102,620 - 167,109,157 (+)NCBI
Celera4151,715,553 - 151,721,408 (+)NCBICelera
Cytogenetic Map4q42NCBI
LOC102005691
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554137,489,127 - 7,504,956 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554137,489,158 - 7,503,014 (+)NCBIChiLan1.0ChiLan1.0
LOC100687968
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,059,707 - 36,068,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,555,689 - 10,564,069 (-)NCBI
ROS_Cfam_1.02736,406,096 - 36,414,471 (+)NCBI
UMICH_Zoey_3.12736,293,162 - 36,301,539 (+)NCBI
UNSW_CanFamBas_1.02736,316,965 - 36,325,348 (+)NCBI
UU_Cfam_GSD_1.02710,077,763 - 10,086,143 (-)NCBI
LOC101976242
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,084,874 - 97,099,433 (+)NCBI
SpeTri2.0NW_004936902216,495 - 229,150 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100519314
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1561,724,744 - 61,736,667 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,653,296 - 64,665,221 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,207,066 - 10,223,922 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,207,211 - 10,223,899 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660892,283,754 - 2,301,143 (-)NCBIVero_WHO_p1.0

Position Markers
STS-X54870  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371210,525,452 - 10,525,666UniSTSGRCh37
Build 361210,416,719 - 10,416,933RGDNCBI36
Celera1215,687,300 - 15,687,514RGD
Cytogenetic Map12pUniSTS
Cytogenetic Map12p13.2-p12.3UniSTS
HuRef1210,267,879 - 10,268,093UniSTS
GeneMap99-GB4 RH Map1262.08UniSTS
NCBI RH Map12160.3UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2917
Count of miRNA genes:569
Interacting mature miRNAs:613
Transcripts:ENST00000539300, ENST00000539370, ENST00000543572, ENST00000543812, ENST00000585507, ENST00000585711, ENST00000586581, ENST00000588263, ENST00000588447, ENST00000590131, ENST00000590323, ENST00000591546, ENST00000591937
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 277 710 258 25 1046 14 151 15 44 15 208 726 11 333 42
Low 1952 1810 1278 480 510 330 3276 1508 3320 190 1022 615 152 868 2098 1 2
Below cutoff 197 450 282 206 335 204 772 640 328 262 244 264 11 1 3 638 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000539300   ⟹   ENSP00000455951
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,372,906 - 10,409,549 (-)Ensembl
RefSeq Acc Id: ENST00000539370
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,379,366 - 10,409,549 (-)Ensembl
RefSeq Acc Id: ENST00000543572   ⟹   ENSP00000456286
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,372,353 - 10,407,766 (-)Ensembl
RefSeq Acc Id: ENST00000543812   ⟹   ENSP00000457500
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,372,991 - 10,410,146 (-)Ensembl
RefSeq Acc Id: ENST00000585507   ⟹   ENSP00000465434
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,379,700 - 10,410,128 (-)Ensembl
RefSeq Acc Id: ENST00000585711   ⟹   ENSP00000467316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,373,059 - 10,407,759 (-)Ensembl
RefSeq Acc Id: ENST00000586581   ⟹   ENSP00000467228
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,373,059 - 10,409,549 (-)Ensembl
RefSeq Acc Id: ENST00000588263   ⟹   ENSP00000468074
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,378,132 - 10,410,128 (-)Ensembl
RefSeq Acc Id: ENST00000588447   ⟹   ENSP00000465254
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,378,554 - 10,410,128 (-)Ensembl
RefSeq Acc Id: ENST00000590131   ⟹   ENSP00000467152
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,373,082 - 10,410,128 (-)Ensembl
RefSeq Acc Id: ENST00000590323   ⟹   ENSP00000467880
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,378,575 - 10,410,128 (-)Ensembl
RefSeq Acc Id: ENST00000591546   ⟹   ENSP00000468432
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,373,059 - 10,410,128 (-)Ensembl
RefSeq Acc Id: ENST00000591937   ⟹   ENSP00000466326
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1210,379,766 - 10,410,128 (-)Ensembl
RefSeq Acc Id: NM_001199805   ⟹   NP_001186734
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381210,372,353 - 10,410,146 (-)NCBI
GRCh371210,524,952 - 10,562,745 (-)NCBI
HuRef1210,267,379 - 10,305,170 (-)NCBI
CHM1_11210,494,385 - 10,532,177 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001186734 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL35226 (Get FASTA)   NCBI Sequence Viewer  
  AAL65233 (Get FASTA)   NCBI Sequence Viewer  
  BAF84709 (Get FASTA)   NCBI Sequence Viewer  
  CAA38652 (Get FASTA)   NCBI Sequence Viewer  
  P26718 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001186734   ⟸   NM_001199805
- UniProtKB: P26718 (UniProtKB/Swiss-Prot),   A0A024RAP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000457500   ⟸   ENST00000543812
RefSeq Acc Id: ENSP00000456286   ⟸   ENST00000543572
RefSeq Acc Id: ENSP00000467316   ⟸   ENST00000585711
RefSeq Acc Id: ENSP00000465434   ⟸   ENST00000585507
RefSeq Acc Id: ENSP00000467228   ⟸   ENST00000586581
RefSeq Acc Id: ENSP00000465254   ⟸   ENST00000588447
RefSeq Acc Id: ENSP00000468074   ⟸   ENST00000588263
RefSeq Acc Id: ENSP00000455951   ⟸   ENST00000539300
RefSeq Acc Id: ENSP00000467880   ⟸   ENST00000590323
RefSeq Acc Id: ENSP00000467152   ⟸   ENST00000590131
RefSeq Acc Id: ENSP00000468432   ⟸   ENST00000591546
RefSeq Acc Id: ENSP00000466326   ⟸   ENST00000591937
Protein Domains
C-type lectin


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.2(chr12:10273008-10633696)x1 copy number loss See cases [RCV000135370] Chr12:10273008..10633696 [GRCh38]
Chr12:10425607..10786295 [GRCh37]
Chr12:10316874..10677562 [NCBI36]
Chr12:12p13.2
uncertain significance
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
NM_007360.4(KLRK1):c.*348C>G single nucleotide variant not provided [RCV001638560] Chr12:10372766 [GRCh38]
Chr12:10525365 [GRCh37]
Chr12:12p13.2
benign
NM_013431.2(KLRC4):c.311A>G (p.Asn104Ser) single nucleotide variant not provided [RCV001679097] Chr12:10408358 [GRCh38]
Chr12:10560957 [GRCh37]
Chr12:12p13.2
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:48357 AgrOrtholog
COSMIC KLRC4-KLRK1 COSMIC
Ensembl Genes ENSG00000213809 Ensembl, UniProtKB/Swiss-Prot
  ENSG00000255819 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSP00000240618 UniProtKB/Swiss-Prot
  ENSP00000446003 UniProtKB/Swiss-Prot
  ENSP00000455951 UniProtKB/TrEMBL
  ENSP00000456286 UniProtKB/TrEMBL
  ENSP00000457500 UniProtKB/TrEMBL
  ENSP00000465254 UniProtKB/TrEMBL
  ENSP00000465434 UniProtKB/TrEMBL
  ENSP00000466326 UniProtKB/TrEMBL
  ENSP00000467152 UniProtKB/TrEMBL
  ENSP00000467228 UniProtKB/TrEMBL
  ENSP00000467316 UniProtKB/TrEMBL
  ENSP00000467880 UniProtKB/TrEMBL
  ENSP00000468074 UniProtKB/TrEMBL
  ENSP00000468432 UniProtKB/TrEMBL
Ensembl Transcript ENST00000240618 UniProtKB/Swiss-Prot
  ENST00000539300 UniProtKB/TrEMBL
  ENST00000540818 UniProtKB/Swiss-Prot
  ENST00000543572 UniProtKB/TrEMBL
  ENST00000543812 UniProtKB/TrEMBL
  ENST00000585507 UniProtKB/TrEMBL
  ENST00000585711 UniProtKB/TrEMBL
  ENST00000586581 UniProtKB/TrEMBL
  ENST00000588263 UniProtKB/TrEMBL
  ENST00000588447 UniProtKB/TrEMBL
  ENST00000590131 UniProtKB/TrEMBL
  ENST00000590323 UniProtKB/TrEMBL
  ENST00000591546 UniProtKB/TrEMBL
  ENST00000591937 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000213809 GTEx
  ENSG00000255819 GTEx
HGNC ID HGNC:48357 ENTREZGENE
Human Proteome Map KLRC4-KLRK1 Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKG2D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:100528032 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hsa:22914 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene KLRC4-KLRK1 ENTREZGENE
PANTHER PTHR47494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RAP8 ENTREZGENE, UniProtKB/TrEMBL
  H3BQV0_HUMAN UniProtKB/TrEMBL
  H3BRK7_HUMAN UniProtKB/TrEMBL
  H3BU71_HUMAN UniProtKB/TrEMBL
  K7EPB6_HUMAN UniProtKB/TrEMBL
  NKG2D_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8K7K5 UniProtKB/Swiss-Prot
  A8K7P4 UniProtKB/Swiss-Prot
  Q9NR41 UniProtKB/Swiss-Prot