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Gene:
Akt1 ( Rattus norvegicus )
v-akt murine thymoma viral oncogene homolog 1
Description:a protein kinase involved in regulation of cell growth, migration, and apoptosis; associated with various cancers and cardiomegaly
Synonyms:Akt; RAC protein kinase alpha, RAC-PK alpha; Murine thymoma viral (v-akt) oncogene homolog 1; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene;  
ArrayIDs:6193924; 5998391; 5740093; 1383126_at; 6309197; D30040_at; 6383255; 1368862_at; 6094433; 6728783; 5748305; A_43_P12733; 5752488; 6072712; 5850193; 1375178_at; GE19486; rc_AA799664_at; 5740257; A_44_P282433; 6172107; 5776417; 6104319;  (details...)
Gene Type:protein-coding
 
Additional Data
primer pair: 635047
 
Homologs
Homo sapiens: AKT1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Akt1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusAkt1genome assembly 3.16137646668 - 137663739
  RH 3.46782.49
  Rat Celera Assembly6129262032 - 129279099
  RGSC genome assembly v3.46137640482 - 137657555
  Cytogenetic6q32
Mus musculusAkt1Mouse genome assembly build 36.112113892032 - 113912401
  Cytogenetic1212 F1
Homo sapiensAKT1human genome assembly14104306752 - 104330608
  Human genome assembly build 36.214104306731 - 104333125
  Cytogenetic14q32.32
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
Gene Ontology
protein kinase activity,  nucleotide binding,  identical protein binding ...  (details...)
Biological Process
NoteReference
may act as a protein-serine/threonine kinase632176
may bind protein kinase C632176
inhibits JUN kinase activation and reduces JNK mediated apoptosis632178
Gene Ontology
positive regulation of nitric oxide biosynthetic process,  positive regulation of cellular protein metabolic process,  germ cell development ...  (details...)
Cellular Component
Gene Ontology
nucleus,  lamellipodium,  soluble fraction ...  (details...)
Disease
Ontology
Carcinoma in Situ,  Kidney Neoplasms,  Ovarian Neoplasms ...  (details...)
Phenotype
Ontology
testicular hypoplasia (details...)
Behavior
Ontology
Schizophrenia,  Mood Disorders (details...)
Expression
NoteReference
expressed in testis and other tissues632176
Pathway
Ontology
altered phosphatodylinositol 3-kinase-Akt signaling pathway,  insulin responsive facilitative sugar transporter mediated glucose transport pathway,  phosphatidylinositol 3-kinase-Akt signaling pathway (details...)
Protein
NoteReference
protein sequence contains 480 amino acids632176
Domain
NoteReference
contains a pleckstrin homology domain632176
contains a protein-serine/threonine kinase catalytic domain632176
Regulation
NoteReference
activity is induced by insulin632177
 
 External Links
Databases
DATABASEIDSOURCE
SMART:S_TKcIPI
SMART:S_TK_XIPI
SMART:PHIPI
PROSITE:PROTEIN_KINASE_STIPI
PROSITE:PROTEIN_KINASE_DOMIPI
PROSITE:PROTEIN_KINASE_ATPIPI
PROSITE:PH_DOMAINIPI
PROSITE:AGC_KINASE_CTERIPI
UNIPARC:UPI000012E044IPI
KEGG Report:rno:24185ENTREZGENE
HomoloGene Group ID:3785ENTREZGENE
Germonline:2081
Pfam:Pkinase_CIPI
Pfam:PkinaseIPI
Pfam:PHIPI
KEGG Pathway:04630ENTREZGENE
KEGG Pathway:04910ENTREZGENE
KEGG Pathway:05214ENTREZGENE
KEGG Pathway:04510ENTREZGENE
KEGG Pathway:04666ENTREZGENE
KEGG Pathway:04664ENTREZGENE
KEGG Pathway:04012ENTREZGENE
KEGG Pathway:05213ENTREZGENE
KEGG Pathway:05210ENTREZGENE
KEGG Pathway:05220ENTREZGENE
KEGG Pathway:04062ENTREZGENE
KEGG Pathway:04662ENTREZGENE
KEGG Pathway:04210ENTREZGENE
KEGG Pathway:04920ENTREZGENE
KEGG Pathway:05221ENTREZGENE
KEGG Pathway:04010ENTREZGENE
KEGG Pathway:04150ENTREZGENE
KEGG Pathway:04370ENTREZGENE
KEGG Pathway:04620ENTREZGENE
KEGG Pathway:04530ENTREZGENE
KEGG Pathway:04660ENTREZGENE
KEGG Pathway:05222ENTREZGENE
KEGG Pathway:05211ENTREZGENE
KEGG Pathway:05215ENTREZGENE
KEGG Pathway:05200ENTREZGENE
KEGG Pathway:05212ENTREZGENE
KEGG Pathway:05223ENTREZGENE
KEGG Pathway:04722ENTREZGENE
KEGG Pathway:05218ENTREZGENE
InterPro:Serine/threonine_Kinase_Rac.IPI
InterPro:Ser/Thr_prot_kinase_dom.IPI
InterPro:Ser/Thr_prot_kinase_AS.IPI
InterPro:Se/Thr_prot_kinase-like_dom.IPI
InterPro:Protein_kinase_ATP_BS.IPI
InterPro:Prot_kinase_cat_dom.IPI
InterPro:Pleckstrin_homology.IPI
InterPro:Pkinase_C.IPI
InterPro:PH_type.IPI
InterPro:Kinase-like_dom.IPI
InterPro:AGC-kinase_C.IPI
Ensembl Protein:ENSRNOP00000038369IPI
IPI:IPI00212844IPI
Gene3D-CATH:PH_typeIPI
Entrez Gene:Akt1ENTREZGENE
TIGR:TC204818
UniProt:AKT1_RATIPI
Ensembl Genes:ENSRNOG00000028629IPI
RatMap:48ENTREZGENE
Superfamily-SCOP:Kinase_likeIPI
PANTHER:AktIPI
Sequences
Nucleotide:CH474034Get FASTASearch GEO Profiles
Nucleotide:D30040Get FASTASearch GEO Profiles
Nucleotide:NM_033230Get FASTASearch GEO Profiles
(View all 3 Nucleotide Accessions)
Protein:P47196Get FASTA
Protein:BAA06279Get FASTA
Protein:EDL97422Get FASTA
Protein:NP_150233Get FASTA
(View all 4 Protein Accessions)
Clusters
UniGene:11422
 
 References
Curated References
38 references in RGD related to Akt1
Other References
225 other references at PubMed related to Akt1
 
 Database Information
RGD ID2081
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
26-SEP-08: Akt1 v-akt murine thymoma viral oncogene homolog 1 Akt1 thymoma viral proto-oncogene 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863
17-NOV-05: Akt1 thymoma viral proto-oncogene 1 v-akt murine thymoma viral oncogene homolog 1 APPROVED Name updated 1299863
14-DEC-04: Akt1 v-akt murine thymoma viral oncogene homolog 1 APPROVED Symbol and Name status set to approved 1299863
10-JUN-02: Akt1 v-akt murine thymoma viral oncogene homolog 1 PROVISIONAL Name updated 70585
05-MAR-01: Akt Murine thymoma viral (v-akt) oncogene homolog 1 WITHDRAWN Symbol withdrawn, allele of Akt1 (RGD:2081) 61033

       

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