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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:3008
Term: bellidifolin
Definition: A member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris.
Chemical ID: MESH:C091291
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1multiple interactionsEXP 6480464CTDbellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of AKT1 mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of AKT1 protein]PMID:36518482
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