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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1affects expressionISOAkt1 (Mus musculus)6480464CTDValproic Acid affects the expression of AKT1 mRNAPMID:17292431
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of AKT1 mRNAPMID:29154799 PMID:29501571
Akt1decreases expressionISOAkt1 (Mus musculus)6480464CTDValproic Acid results in decreased expression of AKT1 mRNAPMID:32445665
Akt1increases expressionISOAKT1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of AKT1 mRNA; Valproic Acid results in increased expression of AKT1 proteinPMID:19440698
Akt1increases methylationISOAKT1 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of AKT1 genePMID:29154799
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDValproic Acid results in increased phosphorylation of AKT1 proteinPMID:19440698
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