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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDMethamphetamine results in decreased phosphorylation of AKT1 proteinPMID:34214594
Akt1increases cleavageEXP 6480464CTDMethamphetamine results in increased cleavage of AKT1 proteinPMID:34214594
Akt1increases phosphorylationEXP 6480464CTDMethamphetamine results in increased phosphorylation of AKT1 proteinPMID:32035215 PMID:35863504
Akt1multiple interactionsEXP 6480464CTDDDIT3 protein affects the reaction [Methamphetamine results in decreased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 proteinPMID:30742852 PMID:32035215 PMID:34214594
Akt1affects phosphorylationISOAKT1 (Homo sapiens)6480464CTDMethamphetamine affects the phosphorylation of AKT1 proteinPMID:31270305
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDMethamphetamine results in decreased phosphorylation of AKT1 proteinPMID:29981415
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDMethamphetamine results in increased phosphorylation of AKT1 proteinPMID:26887589
Akt1increases response to substanceISOAKT1 (Homo sapiens)6480464CTDAKT1 gene SNP results in increased susceptibility to MethamphetaminePMID:15982448
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[Rosiglitazone co-treated with Methamphetamine] results in increased phosphorylation of AKT1 proteinPMID:31270305
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDrosiglitazone inhibits the reaction [Methamphetamine results in decreased phosphorylation of AKT1 protein]PMID:29981415
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