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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDCarmustine results in decreased phosphorylation of AKT1 proteinPMID:19860839
Akt1multiple interactionsEXP 6480464CTDLCN2 protein promotes the reaction [Carmustine results in decreased phosphorylation of AKT1 protein]PMID:19860839
Akt1affects response to substanceISOAKT1 (Homo sapiens)6480464CTDAKT1 protein affects the susceptibility to CarmustinePMID:18430789
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