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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:37550
Term: sphingosine 1-phosphate
Definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Chemical ID: MESH:C060506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDsphingosine 1-phosphate results in increased phosphorylation of AKT1 proteinPMID:15946935
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDsphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 proteinPMID:16365044
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