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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased expression of AKT1 proteinPMID:35218280
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased phosphorylation of AKT1 proteinPMID:23954321
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; [epigallocatechin gallate co-treated with Quercetin] promotes the reaction [Docetaxel results in decreased phosphorylation of AKT1 protein]; [epigallocatechin gallate co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Docetaxel promotes the reaction [[epigallocatechin gallate co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein]; epigallocatechin gallate inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]PMID:19244381 PMID:25655047 PMID:29061316
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDepigallocatechin gallate inhibits the reaction [Imiquimod results in increased phosphorylation of AKT1 protein]; epigallocatechin gallate results in decreased expression of and results in decreased phosphorylation of AKT1 proteinPMID:29402411 PMID:34600025
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