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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:5186
Term: fucoxanthin
Definition: An epoxycarotenol that is found in brown seaweed and which exhibits anti-cancer, anti-diabetic, anti-oxidative and neuroprotective properties.
Chemical ID: MESH:C025164
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDfucoxanthin results in decreased expression of AKT1 mRNAPMID:35266250
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDfucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of AKT1 protein]PMID:26418808
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