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GENE - TERM ANNOTATION REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: DOID:9256
Term: colorectal cancer
Definition: A large intestine cancer that is located_in the colon and/or located_in the rectum. (DO)
Definition Source(s): http://www.cancer.gov/dictionary?CdrID=444983 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1amelioratesISOAKT1 (Homo sapiens)151893289RGDhuman cells in mouse model 
Akt1disease_progressionISOAKT1 (Homo sapiens)13209139RGDprotein:increased serine phosphorylation:colon 
Akt1susceptibilityISOAKT1 (Homo sapiens)1643334RGDDNA:point mutation:cds:p.E17K (human) 
Akt1 ISOAKT1 (Homo sapiens)7240710OMIM  
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