GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | decreases expression | EXP | | 6480464 | CTD | Gefitinib results in decreased expression of AKT1 mRNA | PMID:32370496 | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Gefitinib results in decreased phosphorylation of AKT1 protein | PMID:36807944 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Gefitinib affects the reaction [ON123300 results in decreased phosphorylation of AKT1 protein]; Gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of AKT1 protein]; Gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Gefitinib results in decreased expression of and results in decreased phosphorylation of AKT1 protein; leptomycin B inhibits the reaction [Gefitinib results in decreased phosphorylation of AKT1 protein] | PMID:17805209 PMID:19233551 PMID:24568969 PMID:27087131 PMID:28942004 PMID:30993382 | Akt1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Gefitinib inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Gefitinib inhibits the reaction [Folic Acid results in increased phosphorylation of AKT1 protein] | PMID:23255615 PMID:23948867 | |
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