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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDAtorvastatin results in decreased phosphorylation of AKT1 proteinPMID:27345130 PMID:27815113
Akt1multiple interactionsEXP 6480464CTD[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]PMID:27345130 PMID:32259528
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDAtorvastatin results in increased phosphorylation of AKT1 proteinPMID:19526287
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; Atorvastatin results in decreased expression of and results in decreased phosphorylation of AKT1 proteinPMID:18172863 PMID:29630879
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDAtorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein]PMID:20305681
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