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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of AKT1 protein modified formPMID:28439067
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in decreased phosphorylation of AKT1 proteinPMID:33844015
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased phosphorylation of AKT1 proteinPMID:28288859
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid promotes the reaction [ITPR1 protein binds to AKT1 protein]PMID:28288859
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