GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | crizotinib results in decreased phosphorylation of AKT1 protein | PMID:22553343 PMID:22729845 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; MET gene mutant form promotes the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein] | PMID:22553343 PMID:22729845 | |
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