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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:69581
Term: Paeonol
Definition: A methoxybenzene that has formula C9H10O3.
Chemical ID: MESH:C013638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1multiple interactionsEXP 6480464CTD[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]PMID:29505745 PMID:32344236
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDpaeonol inhibits the reaction [Epirubicin results in decreased phosphorylation of AKT1 protein]PMID:26646421
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