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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1affects phosphorylationISOAKT1 (Homo sapiens)6480464CTDCamptothecin affects the phosphorylation of AKT1 proteinPMID:24095863
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDCamptothecin results in increased phosphorylation of AKT1 proteinPMID:30851366
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Camptothecin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased phosphorylation of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]PMID:24095863 PMID:30851366 PMID:36394428
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