GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | multiple interactions | EXP | | 6480464 | CTD | AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein | PMID:17372590 PMID:17640564 PMID:25541178 PMID:27966075 PMID:34577062 | Akt1 | affects phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Curcumin affects the phosphorylation of AKT1 protein | PMID:27208389 | Akt1 | decreases activity | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased activity of AKT1 protein | PMID:16023083 | Akt1 | decreases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein | PMID:24211270 PMID:26409325 | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased phosphorylation of AKT1 protein | PMID:17289836 PMID:17332930 PMID:17596214 PMID:18790744 PMID:19372569 PMID:20605902 PMID:23555722 PMID:24365254 PMID:34634291 PMID:37471645 | Akt1 | decreases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Curcumin results in decreased phosphorylation of AKT1 protein | PMID:18006147 PMID:36640941 | Akt1 | increases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Curcumin results in increased expression of AKT1 protein | PMID:23222814 | Akt1 | increases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Curcumin results in increased phosphorylation of AKT1 protein | PMID:20938987 | Akt1 | increases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Curcumin results in increased phosphorylation of AKT1 protein | PMID:17535857 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] | PMID:16219905 PMID:17291458 PMID:17640567 PMID:17918158 PMID:18214481 PMID:18660423 PMID:18790744 PMID:20605902 PMID:20727180 PMID:20938987 PMID:23452621 PMID:24831732 PMID:35752269 PMID:36640941 PMID:37471645 | Akt1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] | PMID:17535857 PMID:36640941 | | ||||||||||||||||||||||
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