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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDAtrazine results in decreased phosphorylation of AKT1 proteinPMID:22378314
Akt1increases expressionISOAKT1 (Homo sapiens)6480464CTDAtrazine results in increased expression of AKT1 mRNAPMID:22378314
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDAtrazine results in increased phosphorylation of AKT1 proteinPMID:18461179
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; U 0126 inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]PMID:27431321
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